Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Fuyuki Tokumasu"'
Autor:
Awet Alem Teklemichael, Aiko Teshima, Asahi Hirata, Momoko Akimoto, Mayumi Taniguchi, Gholam Khodakaramian, Takashi Fujimura, Fuyuki Tokumasu, Kenji Arakawa, Shusaku Mizukami
Publikováno v:
Tropical Medicine and Health, Vol 52, Iss 1, Pp 1-11 (2024)
Abstract Background Natural products play a key role as potential sources of biologically active substances for the discovery of new drugs. This study aimed to identify secondary metabolites from actinomycete library extracts that are potent against
Externí odkaz:
https://doaj.org/article/d497c2553d3142a18b877ee7299c7af5
Autor:
Agriana Rosmalina Hidayati, Melinda, Hilkatul Ilmi, Takaya Sakura, Miako Sakaguchi, Junko Ohmori, Endah Dwi Hartuti, Lidya Tumewu, Daniel Ken Inaoka, Mulyadi Tanjung, Eri Yoshida, Fuyuki Tokumasu, Kiyoshi Kita, Mihoko Mori, Kazuyuki Dobashi, Tomoyoshi Nozaki, Din Syafruddin, Achmad Fuad Hafid, Danang Waluyo, Aty Widyawaruyanti
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 21, Iss , Pp 40-50 (2023)
Nearly half of the world's population is at risk of being infected by Plasmodium falciparum, the pathogen of malaria. Increasing resistance to common antimalarial drugs has encouraged investigations to find compounds with different scaffolds. Extract
Externí odkaz:
https://doaj.org/article/6b134f392fa14e72bc9716284882d2dc
Autor:
Eri Saki H. Hayakawa, Marina Wayama, Fuyuki Tokumasu, Nobuhiko Ohno, Mami Matsumoto, Jiro Usukura
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Plasmodium falciparum gametocytes have unique morphology, metabolism, and protein expression profiles in their asexual stages of development. In addition to the striking changes in their appearance, a wide variety of “exo-membrane structures” are
Externí odkaz:
https://doaj.org/article/87328c10904f46d1b4601ad850fab80e
Autor:
Naoyuki Iso-o, Keisuke Komatsuya, Fuyuki Tokumasu, Noriko Isoo, Tomohiro Ishigaki, Hiroshi Yasui, Hiroshi Yotsuyanagi, Masumi Hara, Kiyoshi Kita
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Malaria parasites cannot multiply in host erythrocytes without cholesterol because they lack complete sterol biosynthesis systems. This suggests parasitized red blood cells (pRBCs) need to capture host sterols, but its mechanism remains unknown. Here
Externí odkaz:
https://doaj.org/article/35b4fa923b6744ca8196c1975c19e9bb
Autor:
Takeshi Q. Tanaka, Suzumi M. Tokuoka, Daichi Nakatani, Fumie Hamano, Shin-ichiro Kawazu, Thomas E. Wellems, Kiyoshi Kita, Takao Shimizu, Fuyuki Tokumasu
Publikováno v:
Biology Open, Vol 8, Iss 7 (2019)
The molecular triggers of sexual differentiation into gametocytes by blood stage Plasmodium falciparum, the most malignant human malaria parasites, are subject of much investigation for potential transmission-blocking strategies. The parasites are re
Externí odkaz:
https://doaj.org/article/7108a90fc5cf44998cde3555ed1aa989
Publikováno v:
Biology Open, Vol 3, Iss 6, Pp 529-541 (2014)
Plasmodium falciparum (Pf) infection remodels the human erythrocyte with new membrane systems, including a modified host erythrocyte membrane (EM), a parasitophorous vacuole membrane (PVM), a tubulovesicular network (TVN), and Maurer's clefts (MC). H
Externí odkaz:
https://doaj.org/article/9fb424bb7c1848eabec8b7b0c0710491
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22975 (2011)
Plasmodium falciparum (Pf) malaria parasites remodel host erythrocytes by placing membranous structures in the host cell cytoplasm and inserting proteins into the surrounding erythrocyte membranes. Dynamic imaging techniques with high spatial and tem
Externí odkaz:
https://doaj.org/article/ea84672c537e49ce97beaf8d081e0c8f
Autor:
Fuyuki Tokumasu, Glenn A Nardone, Graciela R Ostera, Rick M Fairhurst, Steven D Beaudry, Eri Hayakawa, James A Dvorak
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5828 (2009)
BACKGROUND:Hemoglobin C differs from normal hemoglobin A by a glutamate-to-lysine substitution at position 6 of beta globin and is oxidatively unstable. Compared to homozygous AA erythrocytes, homozygous CC erythrocytes contain higher levels of membr
Externí odkaz:
https://doaj.org/article/f9ee996397a34ade8f677ddad4b4d4ad
Autor:
Kota Mochizuki, Daniel Ken Inaoka, Shinjiro Hamano, Takaya Sakura, Eri Yoshida, Kazuro Shiomi, Fuyuki Tokumasu, Yuichi Matsuo, Mohammed S. O. Tagod, Danang Waluyo, Tomoyoshi Nozaki, Rajib Acharjee, Xinying Wang, Kiyoshi Kita, Endah Dwi Hartuti, Tomoo Shiba, Mihoko Mori
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 13
International Journal of Molecular Sciences, Vol 22, Iss 7236, p 7236 (2021)
Volume 22
Issue 13
International Journal of Molecular Sciences, Vol 22, Iss 7236, p 7236 (2021)
Plasmodium falciparum’s resistance to available antimalarial drugs highlights the need for the development of novel drugs. Pyrimidine de novo biosynthesis is a validated drug target for the prevention and treatment of malaria infection. P. falcipar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9d71680d16d0fcd50ba284bb794dfb
https://pubmed.ncbi.nlm.nih.gov/34281290
https://pubmed.ncbi.nlm.nih.gov/34281290
Autor:
Daniel Ken Inaoka, Shigeharu Harada, Yasutoshi Kido, Kimitoshi Sakamoto, Paul A.M. Michels, Tomoo Shiba, Suzumi M. Tokuoka, Yoh-ichi Watanabe, Emmanuel Oluwadare Balogun, Kiyoshi Kita, Fuyuki Tokumasu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:2830-2842
Background In general, glycerol kinases (GKs) are transferases that catalyze phospho group transfer from ATP to glycerol, and the mechanism was suggested to be random bi-bi. The reverse reaction i.e. phospho transfer from glycerol 3-phosphate (G3P) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d2ed3c207b7aa53615178108a307f2
https://doi.org/10.1016/j.bbagen.2017.07.028
https://doi.org/10.1016/j.bbagen.2017.07.028