Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Fuyao, Li"'
Autor:
Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Aishe Kurti, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, Guojun Bu
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Background The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer’s disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domain. Ectopic expre
Externí odkaz:
https://doaj.org/article/aeb26e05f9954b82bf1169b444687ab2
Autor:
Kai Chen, Yuka A. Martens, Axel Meneses, Daniel H. Ryu, Wenyan Lu, Ana Caroline Raulin, Fuyao Li, Jing Zhao, Yixing Chen, Yunjung Jin, Cynthia Linares, Marshall Goodwin, Yonghe Li, Chia-Chen Liu, Takahisa Kanekiyo, David M. Holtzman, Todd E. Golde, Guojun Bu, Na Zhao
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-14 (2022)
Abstract Background The aggregation and spread of α-synuclein (α-Syn) protein and related neuronal toxicity are the key pathological features of Parkinson’s disease (PD) and Lewy body dementia (LBD). Studies have shown that pathological species o
Externí odkaz:
https://doaj.org/article/6cbd01c19d96474d84a60117d4afbc0d
Autor:
Yunjung Jin1, Fuyao Li1, Zonghua Li1, Ikezu, Tadafumi C.2, O'Leary, Justin1, Selvaraj, Manikandan1, Yiyang Zhu1, Martens, Yuka A.1, Shunsuke Koga1,3, Santhakumar, Hannah1, Yonghe Li1, Wenyan Lu1, Yang You1, Lolo, Kiara1, DeTure, Michael1, Beasley, Alexandra I.1, Davis, Mary D.1, McLean, Pamela J.1, Ross, Owen A.1, Takahisa Kanekiyo1
Publikováno v:
Science Advances. 9/13/2024, Vol. 10 Issue 37, p1-20. 20p.
Autor:
Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Aishe Kurti, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, Guojun Bu
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4511001c5918420e8c1acb46c93860e6
Autor:
Hufang Zhou, Wenhua Peng, Fuyao Li, Yuelin Wang, Baofu Wang, Yukun Ding, Qian Lin, Ying Zhao, Guozhong Pan, Xian Wang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundHeart failure with preserved ejection fraction (HFpEF) is associated with a high risk of mortality and frequent hospitalization. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have favorable cardiovascular protective effect and could dec
Externí odkaz:
https://doaj.org/article/43241b190a79446b8ab0b637c288df3c
Publikováno v:
Lithosphere, Vol 2022, Iss 1 (2022)
AbstractThe composite salt formations in West China are characterized by the deep burial, complex tectonic stress, and alternating development of salt rock and mudstone, and salt rock creep during drilling poses great challenges to the safety of dril
Externí odkaz:
https://doaj.org/article/e9592d12792044daab23ff210e0e4475
Autor:
Axel D. Meneses, Shunsuke Koga, Zonghua Li, Justin O'Leary, Fuyao Li, Kai Chen, Aya Murakami, Wenhui Qiao, Aishe Kurti, Michael G. Heckman, Launia White, Manling Xie, Yixing Chen, Nicole A. Finch, Melina J. Lim, Marion Delenclos, Michael A. DeTure, Cynthia Linares, Nicholas B. Martin, Tadafumi C. Ikezu, Marka M. van Blitterswijk, Long‐Jun Wu, Pamela J. McLean, Rosa Rademakers, Owen A. Ross, Dennis W. Dickson, Guojun Bu, Na Zhao
Publikováno v:
Annals of Neurology. 93:830-843
Recent evidence supports a link between increased TDP-43 burden and the presence of an APOE4 gene allele in Alzheimer's disease (AD); however, it is difficult to conclude the direct effect of APOE on TDP-43 pathology due to the presence of mixed AD p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abc16fcf71fc09db1e54ab7638e76af
https://doi.org/10.1002/ana.26580
https://doi.org/10.1002/ana.26580
Publikováno v:
The Journal of Physical Chemistry B.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50ae131d6a78fb43f11293ec640cca5
https://doi.org/10.1021/acs.jpcb.3c01912
https://doi.org/10.1021/acs.jpcb.3c01912
Autor:
Yunjung Jin, Fuyao Li, Berkiye Sonoustoun, Naveen Chandra Kondru, Yuka A. Martens, Wenhui Qiao, Michael G. Heckman, Tadafumi C. Ikezu, Zonghua Li, Jeremy D. Burgess, Danilyn Amerna, Justin O’Leary, Michael A. DeTure, Jing Zhao, Pamela J. McLean, Dennis W. Dickson, Owen A. Ross, Guojun Bu, Na Zhao
Publikováno v:
Acta Neuropathologica. 143:641-662
Approximately half of Alzheimer’s disease (AD) brains have concomitant Lewy pathology at autopsy, suggesting that α-synuclein (α-SYN) aggregation is a regulated event in the pathogenesis of AD. Genome-wide association studies revealed that the ε
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe046db23f2c71b438ae91254c8dc0a3
https://doi.org/10.1007/s00401-022-02421-8
https://doi.org/10.1007/s00401-022-02421-8
Autor:
Na Zhao, Wenhui Qiao, Fuyao Li, Yingxue Ren, Jiaying Zheng, Yuka A. Martens, Xusheng Wang, Ling Li, Chia-Chen Liu, Kai Chen, Yiyang Zhu, Tadafumi C. Ikezu, Zonghua Li, Axel D. Meneses, Yunjung Jin, Joshua A. Knight, Yixing Chen, Ligia Bastea, Cynthia Linares, Berkiye Sonustun, Lucy Job, Madeleine L. Smith, Manling Xie, Yong U. Liu, Anthony D. Umpierre, Koichiro Haruwaka, Zachary S. Quicksall, Peter Storz, Yan W. Asmann, Long-Jun Wu, Guojun Bu
Publikováno v:
Journal of Experimental Medicine. 219
TREM2 is exclusively expressed by microglia in the brain and is strongly linked to the risk for Alzheimer’s disease (AD). As microglial responses modulated by TREM2 are central to AD pathogenesis, enhancing TREM2 signaling has been explored as an A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff47cd46285efea4757fe778fe1d7ac
https://doi.org/10.1084/jem.20212479
https://doi.org/10.1084/jem.20212479