Zobrazeno 1 - 10
of 1 466
pro vyhledávání: '"Fuu‑Jen Tsai"'
Autor:
Eddie T. C. Huang, Jai-Sing Yang, Ken Y. K. Liao, Warren C. W. Tseng, C. K. Lee, Michelle Gill, Colin Compas, Simon See, Fuu-Jen Tsai
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Predicting the blood–brain barrier (BBB) permeability of small-molecule compounds using a novel artificial intelligence platform is necessary for drug discovery. Machine learning and a large language model on artificial intelligence (AI) t
Externí odkaz:
https://doaj.org/article/8190bad13ade401e9fc672d022741f7e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Associations between migraine and retinal vascular occlusion have been reported, but there is no large-scale and comprehensive study. Therefore, we aimed to determine risks of retinal vascular occlusion in patients with migraine. Using the T
Externí odkaz:
https://doaj.org/article/02626b7c7925428d99ae62bf4fb167e2
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Chronic Obstructive Pulmonary Disease (COPD) describes a group of progressive lung diseases causing breathing difficulties. While COPD development typically involves a complex interplay between genetic and environmental factors, g
Externí odkaz:
https://doaj.org/article/4dd87f0c58ce4d90937b41a66aa2f5e6
Autor:
Hsiao-Lan Chen, Chia-Hung Chen, Wen-Che Hsieh, Yu-Han Huang, Tzu-Ju Hsu, Fuu-Jen Tsai, Yung-Chi Cheng, Chao-Yu Hsu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract This study aimed to investigate the association between obesity and herpes zoster (HZ) occurrence. This study used data covering 2 million people in Taiwan in 2000, which were obtained from the National Health Insurance Research Database. Th
Externí odkaz:
https://doaj.org/article/9471562d7e3a4de6b818b2e529869cda
Autor:
Hou-Kuang Chen, Yow-Wen Hsieh, Hsing-Yu Hsu, Ting-Yuan Liu, Yu-Ting Zhang, Chia-Der Lin, Fuu-Jen Tsai
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Background Previous studies have implicated inherited mutations in mitochondrial DNA (mtDNA) in sensorineural hearing loss (SNHL). However, the definitive association between mitochondrial 12S rRNA (MT-RNR1) variants and hearing loss in the
Externí odkaz:
https://doaj.org/article/59948b41ecf04546a285c926e634de54
Autor:
Ting-Hsuan Sun, Chia-Chun Wang, Ting-Yuan Liu, Shih-Chang Lo, Yi-Xuan Huang, Shang-Yu Chien, Yu-De Chu, Fuu-Jen Tsai, Kai-Cheng Hsu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Polygenic scores estimate genetic susceptibility to diseases. We systematically calculated polygenic scores across 457 phenotypes using genotyping array data from China Medical University Hospital. Logistic regression models assessed polygen
Externí odkaz:
https://doaj.org/article/2efb63d85e9c4c62a5c95981aac0be1c
Autor:
Chung-Hsing Wang, Yu‐Nan Huang, Wen-Ling Liao, Ai-Ru Hsieh, Wei-De Lin, Kai-Wen Liu, Wen-Li Lu, Chieh‐Chen Huang, Yin-Hsiu Chien, Ni-Chung Lee, Pen-Hua Su, Fuu-Jen Tsai
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Background Osteoporosis and its primary complication, fragility fractures, contribute to substantial global morbidity and mortality. Gaucher disease (GD) is caused by glucocerebrosidase (GBA1) deficiency, leading to skeletal complications. T
Externí odkaz:
https://doaj.org/article/0c1baf8b9b3b4b928fe4f713814a049b
Autor:
Cheng-Wei Yu, Chia-Hung Chen, Yung-Chi Cheng, Wen-Che Hsieh, Tzu-Ju Hsu, Fuu-Jen Tsai, Chao-Yu Hsu
Publikováno v:
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-10 (2023)
Abstract Background Disease-related stress can trigger the occurrence of herpes zoster (HZ). Fatty liver disease (FLD) can have adverse effects on the human body and may induce stress in affected individuals. In this study, we investigated whether FL
Externí odkaz:
https://doaj.org/article/b90330cd87244f14b7ca4fdebf009279
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss 1 (2024)
Objective To identify new genetic variants associated with SLE in Taiwan and establish polygenic risk score (PRS) models to improve the early diagnostic accuracy of SLE.Methods The study enrolled 2429 patients with SLE and 48 580 controls from China
Externí odkaz:
https://doaj.org/article/1d24f5e065f249ef95649fc0be2c978d
Autor:
Hui-An Chen, Rai-Hseng Hsu, Ching-Ya Fang, Ankit K. Desai, Ni-Chung Lee, Wuh-Liang Hwu, Fuu-Jen Tsai, Priya S. Kishnani, Yin-Hsiu Chien
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionPompe disease, a lysosomal storage disorder, is characterized by acid α-glucosidase (GAA) deficiency and categorized into two main subtypes: infantile-onset Pompe disease (IOPD) and late-onset Pompe disease (LOPD). The primary treatment,
Externí odkaz:
https://doaj.org/article/d580f3c7d33d45768fcfbe1d68b78034