Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Futoshi Nara"'
Autor:
Satoko Nishimura, Makiko Uno, Yasuyuki Kaneta, Keisuke Fukuchi, Haruyuki Nishigohri, Jun Hasegawa, Hironobu Komori, Shigeki Takeda, Katsuhiko Enomoto, Futoshi Nara, Toshinori Agatsuma
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38618 (2012)
To elucidate the function of MAS-related GPCR, member D (MRGD) in cancers, we investigated the in vitro and in vivo oncogenic function of MRGD using murine fibroblast cell line NIH3T3 in which MRGD is stably expressed. The expression pattern of MRGD
Externí odkaz:
https://doaj.org/article/5ef89b6b48ae48b18795906bda91ef6e
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS Bardoxolone methyl is a covalent Kelch-like ECH-associated protein 1 (Keap1) inhibitor that induces nuclear factor erythroid 2-related factor 2 (Nrf2) activation. Bardoxolone methyl improved glomerular filtration rate (GFR) in cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd4fe471d2388527e339d9a449718776
https://doi.org/10.1093/ndt/gfac074.023
https://doi.org/10.1093/ndt/gfac074.023
Autor:
Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Mary Ann Suico, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama, Misato Kamura, Saki Niinou, Yuimi Koyama, Futoshi Nara, Tsuyoshi Shuto, Kazuhiro Onuma, Hirofumi Kai
Publikováno v:
Kidney360
BACKGROUND: Bardoxolone methyl activates nuclear factor erythroid 2–related factor 2 (Nrf2) via covalent binding and irreversible inhibition of Kelch-like ECH-associated protein 1 (Keap1), the negative regulator of Nrf2. Ongoing clinical trials of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3d502c89ec9099fd5c10558fc0c7bb
https://pubmed.ncbi.nlm.nih.gov/35721612
https://pubmed.ncbi.nlm.nih.gov/35721612
Publikováno v:
The Journal of Physiological Sciences. 69:885-893
Intermittent claudication (IC) is the most common symptom of peripheral arterial disease which significantly deteriorates the quality of life of patients. Exercise training is by far the most effective treatment for IC; however, the underlying mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300c478fba861a13a49bd1049cdbcd56
https://doi.org/10.1007/s12576-019-00701-9
https://doi.org/10.1007/s12576-019-00701-9
Autor:
Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Mary Ann Suico, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama, Misato Kamura, Futoshi Nara, Tsuyoshi Shuto, Kazuhiro Onuma, Hirofumi Kai
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 95:1-YIA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f122231a086e048a53c0f321abe7c2e
https://doi.org/10.1254/jpssuppl.95.0_1-yia-22
https://doi.org/10.1254/jpssuppl.95.0_1-yia-22
Autor:
Keisuke Yamada, Yoh-ichi Tagawa, Tsuyoshi Homma, Futoshi Nara, Takahiro Nagayama, Shin-ichi Inoue, Masaki Meguro, Satoru Miyauchi, Shinji Furuzono
Publikováno v:
European Journal of Pharmacology. 795:58-65
It has been elucidated that mineralocorticoid receptor antagonists reduce mortality in patients with congestive heart failure and post-acute myocardial infarction. A direct inhibition of aldosterone synthase (CYP11B2) is also expected to have therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c2bb2b3a0988386f9763721f509090
https://doi.org/10.1016/j.ejphar.2016.11.049
https://doi.org/10.1016/j.ejphar.2016.11.049
Autor:
Jeff D. Reagan, Hiroaki Maeda, Harumi Kuwabara, Michiko Murakoshi, Miyuki Nagasaki, Futoshi Nara, Yu Mei Xiong
Publikováno v:
Journal of Receptors and Signal Transduction. 37:290-296
GPR142 is a G-protein-coupled receptor (GPCR), whose most potent and efficacious ligand has been reported as being the natural amino acid l-tryptophan. GPR142 is highly expressed in pancreatic β-cells and immune cells, suggesting the receptor may pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f802ddd0163536110761132a4b24f055
https://doi.org/10.1080/10799893.2016.1247861
https://doi.org/10.1080/10799893.2016.1247861
Publikováno v:
Journal of Pharmacy and Pharmacology. 69:43-51
Objectives Recently, there has been a growing interest in the mechanism of action of dichloroacetate (DCA) for T-cell differentiation; however, this mechanism has not been elucidated in detail. Therefore, this study aimed to investigate the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f027cd3e72e12d318fb3c7fe58f5a9f
https://doi.org/10.1111/jphp.12655
https://doi.org/10.1111/jphp.12655
Autor:
Kentaro Nagatomo, Suzuki Chikako, Hidetoshi Ishihara, Yuki Nagano, Gabriele Matschiner, Ryuki Miyauchi, Shinji Yamaguchi, Futoshi Nara, Kazuaki Okuno, Tohru Takahashi, Yusuke Masuda, Tomohiro Nishizawa, Takahide Aburatani, Eiko Suzuki, Naotoshi Yamamura, Ryuji Hashimoto
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 365(2)
Since it was recently reported that an antibody for proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces the risk of cardiovascular events in a clinical context, PCSK9 inhibition is thought to be an attractive therapy for dyslipidemia. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22500a7a074f42e5b631d6fcde54b62
https://pubmed.ncbi.nlm.nih.gov/29463608
https://pubmed.ncbi.nlm.nih.gov/29463608
Autor:
Satoru Naito, Kiyoshi Chiba, Satoru Miyauchi, Shin-ichi Inoue, Keisuke Yamada, Futoshi Nara, Shinji Furuzono, Masaki Meguro, Tsuyoshi Homma, Yukiko Kanao, Kanae Suzuki
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(9)
2,2,2-Trifluoro-1-{4-[(4-fluorophenyl)amino]pyrimidin-5-yl}-1-[1-(methylsulfonyl)piperidin-4-yl]ethanol 1 was identified as a novel potent aldosterone synthase inhibitor. Despite large species differences, compound 1 inhibits both human and rodent CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a631fa9cd4b4a16db8a9097cc54aeefc
https://pubmed.ncbi.nlm.nih.gov/28359792
https://pubmed.ncbi.nlm.nih.gov/28359792