Cigarette Smoking‐Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets

Autor: Curtis Lee Lowery, Clay Elliott, Anthonya Cooper, Coedy Hadden, Roberto N. Sonon, Parastoo Azadi, D. Keith Williams, James D. Marsh, Donna S. Woulfe, Fusun Kilic

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)

BackgroundCigarette smoking plays a major role in cardiovascular diseases. The acute effects of cigarette smoking produce central nervous system–mediated activation of the sympathetic nervous system. The overactive sympathetic nervous system stimul

Externí odkaz: https://doaj.org/article/30ff2937ed594d27a398794e4f71035d

The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network.

Autor: Billow A Ahmed, Irfan A Bukhari, Brandon C Jeffus, Justin T Harney, Sheeno Thyparambil, Endrit Ziu, Mony Fraer, Nancy J Rusch, Piotr Zimniak, Vladimir Lupashin, Dale Tang, Fusun Kilic

Publikováno v: PLoS ONE, Vol 4, Iss 3, p e4730 (2009)

BACKGROUND:The C-terminus of the serotonin transporter (SERT) contains binding domains for different proteins and is critical for its functional expression. In endogenous and heterologous expression systems, our proteomic and biochemical analysis dem

Externí odkaz: https://doaj.org/article/e92dc1d42a694d39b32a7e31ed566e0d

Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway

Autor: Tariq Fahmi, Drucilla J. Roberts, Alena V. Savenka, Vladimir Lupashin, Coedy Hadden, Sylvie Hauguel-de Mouzon, Anthonya Cooper, Fusun Kilic, Luc Maroteaux

Publikováno v: Journal of Cellular Physiology
Journal of Cellular Physiology, Wiley, 2017, 232 (12), pp.3520-3529. ⟨10.1002/jcp.25812⟩
Journal of Cellular Physiology, 2017, 232 (12), pp.3520-3529. ⟨10.1002/jcp.25812⟩

International audience; Serotonin (5-HT) and its specific transporter, SERT play important roles in pregnancy. Using placentas dissected from 18d gestational SERT-knock out (KO), peripheral 5-HT (TPH1)-KO, and wild-type (WT) mice, we explored the rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675c14595222cd9fbc4ccc840b2c8523
https://doi.org/10.1002/jcp.25812

Withdrawal: Discrepancy in insulin regulation between gestational diabetes mellitus (GDM) platelets and placenta

Autor: Drucilla J. Roberts, Anthonya Cooper, Yicong Li, Nafisa K. Dajani, Fusun Kilic, Luc Maroteaux, Imelda N. Odibo, Ruston Koonce, Asli Ahmed, Pamela Murphy, Curtis L. Lowery

Earlier findings have identified the requirement of insulin signaling on maturation and the translocation of serotonin (5-HT) transporter, SERT to the plasma membrane of the trophoblast in placenta. Because of the defect on insulin receptor (IR) in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46dde824d311907adb175edfbbd042c
https://europepmc.org/articles/PMC6579478/

Expression of Concern: Discrepancy in insulin regulation between gestational diabetes mellitus (GDM) platelets and placenta

Autor: Pamela Murphy, Fusun Kilic, Luc Maroteaux, Curtis L. Lowery, Yicong Li, Asli Ahmed, Ruston Koonce, Nafisa K. Dajani, Imelda N. Odibo, Drucilla J. Roberts, Anthonya Cooper

Earlier findings have identified the requirement of insulin signaling on maturation and the translocation of serotonin (5-HT) transporter, SERT to the plasma membrane of the trophoblast in placenta. Because of the defect on insulin receptor (IR) in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893c8ccd02a3cd323c6e54a4dc4c5704
https://europepmc.org/articles/PMC6442031/