Zobrazeno 1 - 10
of 1 249
pro vyhledávání: '"Fusion genes"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Prostate cancer (PCa) is a highly heterogeneous disease, encompassing various molecular and clinical pathological subtypes. Fusion genes play a facilitating role in the occurrence and progression of PCa. We categorized PCa samples into the E
Externí odkaz:
https://doaj.org/article/947b3ab22d5747aa819e410af30c5ec4
Publikováno v:
Clinical and Translational Discovery, Vol 4, Iss 4, Pp n/a-n/a (2024)
Abstract Background The concept of gene fusion describes the process of fusing two genes into one, which is closely linked to tumour occurrence and development and may even be the direct cause of some tumours. Due to their tumour‐specific expressio
Externí odkaz:
https://doaj.org/article/8cf3f9bacfa44276a7f2b52d1f8f252f
Autor:
Patrick S. Plum, Timo Hess, Denis Bertrand, Isabelle Morgenstern, Oscar Velazquez Camacho, Christoph Jonas, Christina Alidousty, Britta Wagner, Stephanie Roessler, Thomas Albrecht, Jessica Becker, Vanessa Richartz, Barbara Holz, Sascha Hoppe, Huay Mei Poh, Burton Kuan Hui Chia, Cheryl Xueli Chan, Thushangi Pathiraja, Audrey SM Teo, Jens U. Marquardt, Alexis Khng, Michael Heise, Yao Fei, René Thieme, Sebastian Klein, Jing Han Hong, Simona O Dima, Irinel Popescu, Maria Hoppe‐Lotichius, Reinhard Buettner, Anja Lautem, Gerd Otto, Alexander Quaas, Niranjan Nagarajan, Steve Rozen, Bin Tean Teh, Benjamin Goeppert, Uta Drebber, Hauke Lang, Patrick Tan, Ines Gockel, Johannes Schumacher, Axel M. Hillmer
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Background Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct with a poor prognosis owing to limited therapeutic options. The incidence of intrahepatic CCA (iCCA) is increasing worldwide, and its molecular basis is emerging. Environ
Externí odkaz:
https://doaj.org/article/26260a111e4f40929c73d9cf914a4148
Autor:
China Primary Health Care Foundation Tumor Precision Diagnosis and Treatment Committee, Chinese Anti-Cancer Association, Lung Cancer Study Group of Committee of Oncopathology
Publikováno v:
Chinese Journal of Lung Cancer, Vol 26, Iss 11, Pp 801-812 (2023)
RNA-based next-generation sequencing (NGS) has been recommended as a method for detecting fusion genes in non-small cell lung cancer (NSCLC) according to clinical practice guidelines and expert consensus. The primary targetable alterations in NSCLC c
Externí odkaz:
https://doaj.org/article/73a1d778b7c647e0a77823045380a8a8
Autor:
Sagarajit Mohanty
Publikováno v:
Onco, Vol 3, Iss 3, Pp 147-164 (2023)
NUP98 fusions constitute a small subgroup of AML patients and remain a high-risk AML subtype. There are approximately 30 types of NUP98 fusions identified in AML patients. These patients show resistance to currently available therapies and poor clini
Externí odkaz:
https://doaj.org/article/1cf432c05da847d7aa6ffd977911c749
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/55fb3997d85d47dbadb2f2fe1bcbb6a2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Fibrosarcoma, originating from fibroblast cells, represents a malignant neoplasm that can manifest across all genders and age groups. Fusion genes are notably prevalent within the landscape of human cancers, particularly within the subtypes of fibros
Externí odkaz:
https://doaj.org/article/51cb6d4c99924dda90cd8eb783f92989
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Background: An increasing number of patients are being diagnosed with lung adenocarcinoma, but there remains limited progress in enhancing prognostic outcomes and improving survival rates for these patients. Genome instability is considered a contrib
Externí odkaz:
https://doaj.org/article/5fda93bed3654593a81e443484904aa5
Akademický článek
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Publikováno v:
Cells, Vol 12, Iss 20, p 2467 (2023)
Fusion genes are key cancer driver genes that can be used as potential drug targets in precision therapies, and they can also serve as accurate diagnostic and prognostic biomarkers. The fusion genes can cause microRNA (miRNA/miR) aberrations in many
Externí odkaz:
https://doaj.org/article/26521236f83f440c8f793e9ccf611b12