Zobrazeno 1 - 10
of 357
pro vyhledávání: '"Fusion Toxin"'
Autor:
Sadiya Parveen, Sumit Siddharth, Laurene S. Cheung, Alok Kumar, Jessica Shen, John R. Murphy, Dipali Sharma, William R. Bishai
Publikováno v:
Molecular Oncology, Vol 15, Iss 5, Pp 1330-1344 (2021)
In many solid tumors including triple‐negative breast cancer (TNBC), upregulation of the interleukin‐4 receptor (IL‐4R) has been shown to promote cancer cell proliferation, apoptotic resistance, metastatic potential, and a Th2 response in the t
Externí odkaz:
https://doaj.org/article/065aff525a494219bfd3fbcc76e116b8
Autor:
Zeng Qi, Yue Qiu, Zhaohui Wang, Huiping Zhang, Ling Lu, Yanqiu Liu, David Mathes, Elizabeth A. Pomfret, Dexiang Gao, Shi‐Long Lu, Zhirui Wang
Publikováno v:
Molecular Oncology, Vol 15, Iss 4, Pp 1054-1068 (2021)
Epidermal growth factor receptor (EGFR) is often overexpressed in head and neck squamous cell carcinoma (HNSCC) and represents a top candidate for targeted HNSCC therapy. However, the clinical effectiveness of current Food and Drug Administration (FD
Externí odkaz:
https://doaj.org/article/bfc0a175b0814640b88f3365da6e3127
Autor:
Christian Berg, Mette M. Rosenkilde
Publikováno v:
Berg, C & Rosenkilde, M M 2023, ' Therapeutic targeting of HCMV-encoded chemokine receptor US28 : Progress and challenges ', Frontiers in Immunology, vol. 14, 1135280 . https://doi.org/10.3389/fimmu.2023.1135280
The pervasive human cytomegalovirus (HCMV) causes significant morbidity in immunocompromised individuals. Treatment using the current standard-of-care (SOC) is limited by severe toxic adverse effects and anti-viral resistance development. Furthermore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475f8958835e5a44d4ef6714ae863548
https://curis.ku.dk/ws/files/339634055/Therapeutic_targeting.pdf
https://curis.ku.dk/ws/files/339634055/Therapeutic_targeting.pdf
Autor:
Maximilian Fellermann, Christina Huchler, Lea Fechter, Tobias Kolb, Fanny Wondany, Daniel Mayer, Jens Michaelis, Steffen Stenger, Kevin Mellert, Peter Möller, Thomas F. E. Barth, Stephan Fischer, Holger Barth
Publikováno v:
Toxins, Vol 12, Iss 9, p 563 (2020)
C3 protein toxins produced by Clostridium (C.) botulinum and C. limosum are mono-ADP-ribosyltransferases, which specifically modify the GTPases Rho A/B/C in the cytosol of monocytic cells, thereby inhibiting Rho-mediated signal transduction in monocy
Externí odkaz:
https://doaj.org/article/ff20a6a1d10d4376ba38061507670e71
Autor:
Dexiang Gao, Yue Qiu, Zhirui Wang, Zhaohui Wang, Elizabeth A. Pomfret, Shi-Long Lu, Yanqiu Liu, Huiping Zhang, David W. Mathes, Zeng Qi, Ling Lu
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 15, Iss 4, Pp 1054-1068 (2021)
Molecular Oncology, Vol 15, Iss 4, Pp 1054-1068 (2021)
Epidermal growth factor receptor (EGFR) is often overexpressed in head and neck squamous cell carcinoma (HNSCC) and represents a top candidate for targeted HNSCC therapy. However, the clinical effectiveness of current Food and Drug Administration (FD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9233b4524bebd4272f8a9754121a8342
https://doi.org/10.1002/1878-0261.12919
https://doi.org/10.1002/1878-0261.12919
Autor:
Dipali Sharma, John R. Murphy, Jessica Shen, Sadiya Parveen, Sumit Siddharth, Laurene S. Cheung, William R. Bishai, Alok Kumar
Publikováno v:
Molecular Oncology, Vol 15, Iss 5, Pp 1330-1344 (2021)
Molecular Oncology
Molecular Oncology
In many solid tumors including triple‐negative breast cancer (TNBC), upregulation of the interleukin‐4 receptor (IL‐4R) has been shown to promote cancer cell proliferation, apoptotic resistance, metastatic potential, and a Th2 response in the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5973dad70715196b76b3845aeaa4fede
https://doi.org/10.1002/1878-0261.12938
https://doi.org/10.1002/1878-0261.12938
Akademický článek
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Autor:
Mohammad Ali Khalili, Sirus Khodadadi, Maryam Ghodrati Siahmazgi, Mehdi Zeinoddini, Fathollah Ahmadpour
Publikováno v:
Current Computer-Aided Drug Design. 16:238-244
Background:Chemotherapy and radiotherapy have negative effects on normal tissues and they are very expensive and lengthy treatments. These disadvantages have recently attracted researchers to the new methods that specifically affect cancerous tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b18ceeabe8b1e2fb7e4f1f7e8c7e8985
https://doi.org/10.2174/1573409914666181012151242
https://doi.org/10.2174/1573409914666181012151242
Autor:
Haoyu Wang, Zhirui Wang, Huiping Zhang, Christene A. Huang, Erin Rubin, Ariel C. Johnson, Zhaohui Wang, Elizabeth A. Pomfret, David W. Mathes, Zeng Qi
Publikováno v:
Molecular Oncology, Vol 14, Iss 5, Pp 991-1000 (2020)
Molecular Oncology
Molecular Oncology
The majority of clinically diagnosed cutaneous T‐cell lymphomas (CTCL) highly express the cell‐surface markers CC chemokine receptor 4 (CCR4) and/or CD25. Recently, we have developed diphtheria toxin‐based recombinant Ontak®‐like human IL2 f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb4b87f556e97ea8e83ce322d4ca8d3
https://doaj.org/article/5dd4b05d552947d19861213c0fa24315
https://doaj.org/article/5dd4b05d552947d19861213c0fa24315
Autor:
Khalid Mohamedali, Daniel Kedar, Paul Sweeney, Ashish Kamat, Darren W. Davis, Beryl Y. Eve, Samuel Huang, Philip E. Thorpe, Colin P. Dinney, Michael G. Rosenblum
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 10, Pp 912-920 (2005)
Vascular endothelial growth factor. (VEGF) and its receptors. (FLT-1 and KDR) are overexpressed by human bladder cancer cells and tumor endothelial cells, respectively. Strategies that target VEGF receptors hold promise as antlanglogenic therapeutic
Externí odkaz:
https://doaj.org/article/2366fdd91c114e368a18f5263603c8e8