Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Fusen Lin"'
Autor:
Appan Srinivas Kandadai, Bing Bai, Mohammad Rahim, Fusen Lin, Zhengxian Gu, Xinyi Qi, Xuecheng Zhang, Haiheng Dong, Ying Chen, John Shen, James A. Nieman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f619abf91740763cf5762591a1d7d98
https://doi.org/10.2139/ssrn.4352003
https://doi.org/10.2139/ssrn.4352003
Autor:
Muhammad Bashir Khan, Jimmy Lu, Elena Arutyunova, John C. Vederas, James A. Nieman, Howard S. Young, Mohammad Rahim, Yanhua Du, Wayne Vuong, M. Joanne Lemieux, Marco J. van Belkum, Holly A. Saffran, Conrad Fischer, Bing Bai, Alexandr Belovodskiy, Michael A. Joyce, Fusen Lin, Jia Xu, Hena Mostafa, Justin Shields, Darren Hockman, Tess Lamer, D. Lorne Tyrrell, Appan Srinivas Kandadai, Sardeev K Bajwa, Zhengxian Gu
Publikováno v:
Journal of Medicinal Chemistry. 65:2905-2925
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a necessity to develop direct-acting antivirals that can be readily administered and are active against a broad spectrum of coronaviruses. Described in this Article are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::134b04d6422ffafa8fa4be69bcd0a43a
https://doi.org/10.1021/acs.jmedchem.1c00616
https://doi.org/10.1021/acs.jmedchem.1c00616
Autor:
Appan Srinivas Kandadai, Bing Bai, Mohammad Rahim, Fusen Lin, Zhengxian Gu, Xinyi Qi, Xuecheng Zhang, Haiheng Dong, Ying Chen, John Shen, James A. Nieman
Publikováno v:
Bioorganic & Medicinal Chemistry. 85:117276
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f62652040132f8baa9879c7d1f449a62
https://doi.org/10.1016/j.bmc.2023.117276
https://doi.org/10.1016/j.bmc.2023.117276
Autor:
Bing, Bai, Alexandr, Belovodskiy, Mostofa, Hena, Appan Srinivas, Kandadai, Michael A, Joyce, Holly A, Saffran, Justin A, Shields, Muhammad Bashir, Khan, Elena, Arutyunova, Jimmy, Lu, Sardeev K, Bajwa, Darren, Hockman, Conrad, Fischer, Tess, Lamer, Wayne, Vuong, Marco J, van Belkum, Zhengxian, Gu, Fusen, Lin, Yanhua, Du, Jia, Xu, Mohammad, Rahim, Howard S, Young, John C, Vederas, D Lorne, Tyrrell, M Joanne, Lemieux, James A, Nieman
Publikováno v:
Journal of Medicinal Chemistry
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a necessity to develop direct-acting antivirals that can be readily administered and are active against a broad spectrum of coronaviruses. Described in this Article are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ba0e09460619e979a4ea92d8978fe08
https://pubmed.ncbi.nlm.nih.gov/34242027
https://pubmed.ncbi.nlm.nih.gov/34242027
Autor:
Chen Shuhui, Wei Wei, Yunlong Li, Siqi Wu, Zhengxian Gu, Fusen Lin, Haiying He, Xinsheng Chen, Jian Li, Zhiming Su, Hu Guoping, Li Peng, Tianwei Lin, Hao Fei, Tianyichen Xiao
Publikováno v:
Bioorganicmedicinal chemistry. 28(12)
We describe here the design, synthesis, and evaluation of a macrocyclic peptidomimetic as a potent agent targeting enterovirus A71 (EV71). The compound has a 15-membered macrocyclic ring in a defined conformation. Yamaguchi esterification reaction wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511d34a444a986cf2a769f052a639b94
https://pubmed.ncbi.nlm.nih.gov/32503695
https://pubmed.ncbi.nlm.nih.gov/32503695
Autor:
Guo Fengying, Jian Li, Aiming Zhang, Zhengxian Gu, Deming Xu, Hongjiang Xu, Wu Songliang, Jianhua Wang, Jianping Sun, Tian Xin, Fengxun Guo, Haiying He, Chen Shuhui, Zeng Minggao, Fusen Lin, Xiquan Zhang, Zhi Luo, Liang Shen, Wang Chuan, Ling Yang, Mou Jianfeng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1874-1878
A series of caspase inhibitors containing γ-amino acid moiety have been synthesized. A systemic study on their structure-activity relationship of anti-apoptotic cellular activity is presented. These efforts led to the discovery of compound 20o as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883a250f36352cb9e83fbbb849ce1532
https://doi.org/10.1016/j.bmcl.2018.04.002
https://doi.org/10.1016/j.bmcl.2018.04.002
Autor:
Chen Shuhui, Qingming Guo, Hao Fei, Xiujuan Chang, Fusen Lin, Zhang Xiao, Xuyang Shi, Chunyan Du, Haiying He, Jun Yu, Xiao Wei, Wang Zhenzhong, Li Wang, Liang Shen, Li Peng, Jiao Hu, Deming Xu, Hu Guoping, Xinsheng Chen, Jian Li, Zhengxian Gu, Tianwei Lin, Ya Sun, Xuyang Tian
Publikováno v:
ACS Medicinal Chemistry Letters. 8:841-846
Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD), which can spread its infections to the central nervous and other systems with severe consequences. The viral caspid protein VP1 is a well-known target for antiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8036b7eca0babbec7c78059b6824b0
https://doi.org/10.1021/acsmedchemlett.7b00188
https://doi.org/10.1021/acsmedchemlett.7b00188
Autor:
Bing Bai, Belovodskiy, Alexandr, Hena, Mostofa, Kandadai, Appan Srinivas, Joyce, Michael A., Saffran, Holly A., Shields, Justin A., Khan, Muhammad Bashir, Arutyunova, Elena, Jimmy Lu, Bajwa, Sardeev K., Hockman, Darren, Fischer, Conrad, Lamer, Tess, Vuong, Wayne, van Belkum, Marco J., Zhengxian Gu, Fusen Lin, Yanhua Du, Jia Xu
Publikováno v:
Journal of Medicinal Chemistry; 2/24/2022, Vol. 65 Issue 4, p2905-2925, 21p
Autor:
Lai Kunmin, Ya Sun, Chun Yang, Chen Shuhui, Jian Li, Zhengxian Gu, Han Lixia, Liang Shen, Li Guo, Haiying He, Shi Weihua, Tao Zhao, Fusen Lin, Lijuan Hou, Xinsheng Chen, Jiang Zhigan, Zeng Minggao, Fubiao Xiao
A new series of 3,3'-spirocyclic-2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5f20085986bbd96e26b42aeae33976
https://europepmc.org/articles/PMC5900325/
https://europepmc.org/articles/PMC5900325/
Publikováno v:
Journal of Virological Methods. 177:206-210
Herpes simplex virus type 1 (HSV-1) UL3 protein is a nuclear protein. In this study, the molecular mechanism of the subcellular localization of UL3 was characterized by fluorescence microscopy in living cells. A nuclear localization signal (NLS) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa89da4cbedb4256f9763b1617f0ffb
https://doi.org/10.1016/j.jviromet.2011.08.004
https://doi.org/10.1016/j.jviromet.2011.08.004