Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Fused in sarcoma (FUS)"'
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background IL-13Rα2 is one of the most widely studied tumor-associated antigens in glioma research. Fused in sarcoma (FUS) is a DNA/RNA binding protein that is dysfunctional in various malignant tumors. However, the expression of IL-13Rα2
Externí odkaz:
https://doaj.org/article/2143169eb3404b4083734a092e4db98c
Autor:
Alexander Trofimov, Dmitrii Pavlov, Anand Goswami, Anna Gorlova, Kirill Chaprov, Aleksei Umriukhin, Allan Kalueff, Alexey Deykin, Klaus-Peter Lesch, Daniel Clive Anthony, Tatyana Strekalova
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 33, Iss , Pp 100686- (2023)
CNS inflammation, including microglial activation, in response to peripheral infections are known to contribute to the pathology of both familial and sporadic neurodegenerative disease. The relationship between Fused-in-Sarcoma Protein (FUS)-mediated
Externí odkaz:
https://doaj.org/article/80e012cd55704c19bdc25c3f316432fc
Autor:
Ying Liu, Yiwei Liu, Yinqiao He, Ning Zhang, Siyue Zhang, Yaming Li, Xiaolong Wang, Yiran Liang, Xi Chen, Weijing Zhao, Bing Chen, Lijuan Wang, Dan Luo, Qifeng Yang
Publikováno v:
Advanced Science, Vol 10, Iss 10, Pp n/a-n/a (2023)
Abstract Triple‐negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that is suggested to be associated with hypoxia. This study is the first to identify a novel circular RNA (circRNA), circTBC1D14, whose expression is sign
Externí odkaz:
https://doaj.org/article/75cc8ac2254d4faeb1c05e051a8070ab
Autor:
Vincent E. Provasek, Manohar Kodavati, Wenting Guo, Haibo Wang, Istvan Boldogh, Ludo Van Den Bosch, Gavin Britz, Muralidhar L. Hegde
Publikováno v:
Cells, Vol 12, Iss 20, p 2461 (2023)
Fused-in sarcoma (FUS) gene mutations have been implicated in amyotrophic lateral sclerosis (ALS). This study aimed to investigate the impact of FUS mutations (R521H and P525L) on the transcriptome of induced pluripotent stem cells (iPSCs) and iPSC-d
Externí odkaz:
https://doaj.org/article/45341d7d9f1543179cd523fc2fbbad6e
Publikováno v:
Cells, Vol 11, Iss 13, p 2066 (2022)
Since the discovery of Cu/Zn superoxide dismutase (SOD1) gene mutation, in 1993, as the first genetic abnormality in amyotrophic lateral sclerosis (ALS), over 50 genes have been identified as either cause or modifier in ALS and ALS/frontotemporal dem
Externí odkaz:
https://doaj.org/article/d958982a2d064c3a83b3763fabad4b95
Akademický článek
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Autor:
Michelle A. Johnson, Qiudong Deng, Georgia Taylor, Zachary T. McEachin, Anthony W.S. Chan, Jessica Root, Gary J. Bassell, Thomas Kukar
Publikováno v:
Neurobiology of Disease, Vol 146, Iss , Pp 105085- (2020)
Fused in sarcoma (FUS) is a RNA/DNA protein involved in multiple nuclear and cytoplasmic functions including transcription, splicing, mRNA trafficking, and stress granule formation. To accomplish these many functions, FUS must shuttle between cellula
Externí odkaz:
https://doaj.org/article/8d61940c44194c51b4c66fbe11eac637
Autor:
Neha Gogia, Ankita Sarkar, Abijeet Singh Mehta, Ph.D., Nandini Ramesh, Prajakta Deshpande, Madhuri Kango-Singh, Udai Bhan Pandey, Amit Singh
Publikováno v:
Neurobiology of Disease, Vol 140, Iss , Pp 104837- (2020)
Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder characterized by the loss of motor neurons in the central nervous system, has no known cure to-date. Disease causing mutations in human Fused in Sarcoma (FUS) leads to aggre
Externí odkaz:
https://doaj.org/article/a084db8a7dd045d384d9f88084881d68
Autor:
Haiyan An, Lucy Skelt, Antonietta Notaro, J. Robin Highley, Archa H. Fox, Vincenzo La Bella, Vladimir L. Buchman, Tatyana A. Shelkovnikova
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). Mutant FUS is known to confer cytoplasmic gain of function but its effects in the nucleus are less understood. FUS is an essential component of paraspeckles, subnuclear
Externí odkaz:
https://doaj.org/article/4f6970050ae14e91903ae256f98aa4a0
Akademický článek
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