Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Fusako Izumiyama"'
Autor:
Yu F. Sasaki, Kaoru Sekihashi, Shuji Tsuda, Emi Nishidate, Ayako Saga, Kumiko Ishida, Fusako Izumiyama
Publikováno v:
Critical Reviews in Toxicology. 30:629-799
The comet assay is a microgel electrophoresis technique for detecting DNA damage at the level of the single cell. When this technique is applied to detect genotoxicity in experimental animals, the most important advantage is that DNA lesions can be m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfd43319b7a2f9ca7d97ef94463710c
https://doi.org/10.1080/10408440008951123
https://doi.org/10.1080/10408440008951123
Autor:
Emi Nishidate, Naonori Matsusaka, Shuji Tsuda, YūF. Sasaki, Norihide Asano, Kyoko Saotome, Satoko Ishibashi, Toshio Sofuni, Makoto Hayashi, Fusako Izumiyama
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 393:133-139
We exposed two species of shellfish, Patunopecten yessoensis and Tapes japonica , for 4 h to artificial sea water in which N -methyl- N ′-nitro- N -nitrosoguanidine (MNNG), ethyl nitrosourea (EMS), 3-chloro-4-dichloromethyl-5-hydroxy-2( H )-furanon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909212427a89c7a9a42198acf40b59a0
https://doi.org/10.1016/s1383-5718(97)00098-3
https://doi.org/10.1016/s1383-5718(97)00098-3
Autor:
Tatsuro Sekiya, Toshihiro Ohta, Emi Nishidate, Shuji Tsuda, Fusako Izumiyama, Yu F. Sasaki, Yoshiyuki Takahashi, Tomoko Ono
Publikováno v:
Environmental Toxicology and Pharmacology. 3:297-306
We examined the genotoxicity of diaveridine and trimethoprim in the bacterial umu test, the bacterial reverse mutation test, the in vitro chromosome aberration test, the in vivo rodent bone marrow micronucleus test in two species, and the in vivo com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d420396c71ebe21b77c5114b49b9959a
https://doi.org/10.1016/s1382-6689(97)00026-4
https://doi.org/10.1016/s1382-6689(97)00026-4
Autor:
Naohide Kinae, Naonori Matsusaka, Fusako Izumiyama, Mie Watanabe-Akanuma, Shuji Tsuda, Emi Nishidate, YūF. Sasaki
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 393:47-53
We tested the genotoxicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2[5 H ]-furanone (MX) in the mouse in 6 organs (liver, lung, kidney, brain, spleen, and bone marrow) and in the mucosa of stomach, jejunum, ileum, colon, and bladder using the alkali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5f0c15f31e053d8778f68cde3507f4
https://doi.org/10.1016/s1383-5718(97)00085-5
https://doi.org/10.1016/s1383-5718(97)00085-5
Autor:
Emi Nishidate, Shuji Tsuda, YūF. Sasaki, Naonori Matsusaka, Tomoko Ono, Fusako Izumiyama, Toshihiro Ohta
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 392:251-259
We tested the genotoxicity of pyrimethamine in 5 mouse and rat organs (liver, lung, kidney, spleen, and bone marrow) using a modified alkaline single-cell gel electrophoresis (SCG) (Comet) assay. Mice and rats were sacrificed 1, 3, 6, and 24 h after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587e9f30627ee26dac2cc6368e0f6836
https://doi.org/10.1016/s1383-5718(97)00079-x
https://doi.org/10.1016/s1383-5718(97)00079-x
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 388:33-44
The effect of 2 model chemical mutagens on DNA was evaluated with the alkaline single cell gel electrophoresis (SCG) (Comet) assay in 5 mouse organs--liver, lung, kidney, spleen and bone marrow. Mice were sacrificed 3 and 24 h after the administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f19012711070367b7e6b9f7805e8608
https://doi.org/10.1016/s1383-5718(96)00133-7
https://doi.org/10.1016/s1383-5718(96)00133-7
Publikováno v:
Mutation research. 391(3)
We have recently designed a simple method for applying the alkaline single-cell gel electrophoresis (SCG) assay to mouse organs. With this method, each organ is minced, suspended in chilled homogenizing buffer containing NaCl and Na2EDTA, gently homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e81991928e138436b9d8b79a6181f4
https://pubmed.ncbi.nlm.nih.gov/9268046
https://pubmed.ncbi.nlm.nih.gov/9268046
Publikováno v:
Mutation research. 391(3)
Recently, we designed a fast and simple method to obtain nuclei for the alkaline SCG assay and we tested it with mouse liver, lung, kidney, spleen, and bone marrow. Instead of isolating organ cells by trypsinization, we homogenized tissue and isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1467e69fc9d4e58eab7fef93e8455604
https://pubmed.ncbi.nlm.nih.gov/9268047
https://pubmed.ncbi.nlm.nih.gov/9268047