Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes

Autor: King, H, Fursova, NA, Blackledge, NP, Klose, R

Publikováno v: Genome Research

Polycomb group (PcG) proteins are transcriptional repressors that play important roles regulating gene expression during animal development. In vitro experiments have shown that PcG protein complexes can compact chromatin to limit the activity of chr

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Transcriptional machinery as an architect of genome structure.

Autor: Fursova NA; Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 41 Medlars Drive, Bethesda, MD 20892, USA., Larson DR; Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 41 Medlars Drive, Bethesda, MD 20892, USA. Electronic address: dan.larson@nih.gov.

Publikováno v: Current opinion in structural biology [Curr Opin Struct Biol] 2024 Dec; Vol. 89, pp. 102920. Date of Electronic Publication: 2024 Sep 21.

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells.

Autor: McCreery KP; Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany., Stubb A; Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki Finland., Stephens R; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Fursova NA; System Biology of Gene Expression, National Cancer Institute, National Institute of Health, Bethesda, MD 20892., Cook A; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Kruse K; Bioinformatics Service Unit, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany., Michelbach A; Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany., Biggs LC; Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki Finland., Keikhosravi A; High-Throughput Imaging Facility, National Cancer Institute, National Institute of Health, Bethesda, MD 20892., Nykänen S; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki Finland.; Gynecology and Obstetrics, Clinicum, University of Helsinki, 00290 Helsinki, Finland., Hydén-Granskog C; Helsinki University Hospital, Reproductive Medicine Unit, P.O. Box 150, 00029 HUS, Helsinki, Finland., Zou J; iPSC Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Lackmann JW; CECAD Research Center, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany., Niessen CM; Department Cell Biology of the Skin, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Center for Molecular Medicine Cologne, University Hospital Cologne, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany., Vuoristo S; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki Finland.; Gynecology and Obstetrics, Clinicum, University of Helsinki, 00290 Helsinki, Finland.; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland., Miroshnikova YA; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Wickström SA; Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki Finland.; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 07. Date of Electronic Publication: 2024 Sep 07.

HiTIPS: High-Throughput Image Processing Software for the Study of Nuclear Architecture and Gene Expression.

Autor: Keikhosravi A, Almansour F, Bohrer CH, Fursova NA, Guin K, Sood V, Misteli T, Larson DR, Pegoraro G

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 05. Date of Electronic Publication: 2023 Nov 05.

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome.

Autor: Fursova NA; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Turberfield AH; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Blackledge NP; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Findlater EL; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Lastuvkova A; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Huseyin MK; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Dobrinić P; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom., Klose RJ; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom.

Publikováno v: Genes & development [Genes Dev] 2021 May 01; Vol. 35 (9-10), pp. 749-770. Date of Electronic Publication: 2021 Apr 22.