Plasma membrane profiling during enterohemorrhagic E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces

Autor: Furniss, RCD, Low, WW, Mavridou, DAI, Dagley, LF, Webb, AI, Tate, E, Clements, A

Enterohemorrhagic Escherichia coli (EHEC) is one of several E. coli pathotypes that infect the intestinal tract and cause disease. Formation of the characteristic attaching and effacing (A/E) lesion on the surface of infected cells causes significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::08219697107f753ebb820ba7139f0617
http://hdl.handle.net/10044/1/64474

Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection

Autor: Furniss, RCD, Slater, S, Frankel, G, Clements, A

Publikováno v: Journal of Molecular Biology

Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC/EHEC) manipulate a plethora of host cell processes to establish infection of the gut mucosa. This manipulation is achieved via the injection of bacterial effector proteins into host cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::083bcc6f5914d9690e152adc37b69aa1

Making a chink in their armor: Current and next-generation antimicrobial strategies against the bacterial cell envelope.

Autor: Kadeřábková N; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, United States., Mahmood AJS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, United States., Furniss RCD; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom., Mavridou DAI; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, United States; John Ring LaMontagne Center for Infectious Diseases, The University of Texas at Austin, Austin, TX, United States. Electronic address: despoina.mavridou@austin.utexas.edu.

Publikováno v: Advances in microbial physiology [Adv Microb Physiol] 2023; Vol. 83, pp. 221-307. Date of Electronic Publication: 2023 Jun 27.

Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding.

Autor: Furniss RCD; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom., Kaderabkova N; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom.; Department of Molecular Biosciences, University of Texas at Austin, Austin, United States., Barker D; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom., Bernal P; Department of Microbiology, Faculty of Biology, Universidad de Sevilla, Seville, Spain., Maslova E; Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, United Kingdom., Antwi AAA; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom., McNeil HE; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Pugh HL; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Dortet L; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom.; Department of Bacteriology-Hygiene, Bicêtre Hospital, Assistance Publique - Hôpitaux de Paris, Le Kremlin-Bicêtre, France.; EA7361 'Structure, Dynamics, Function and Expression of Broad-spectrum β-lactamases', Paris-Sud University, LabEx Lermit, Faculty of Medicine, Le Kremlin-Bicêtre, France.; French National Reference Centre for Antibiotic Resistance, Le Kremlin-Bicêtre, France., Blair JMA; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom., Larrouy-Maumus G; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom., McCarthy RR; Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, United Kingdom., Gonzalez D; Laboratoire de Microbiologie, Institut de Biologie, Université de Neuchâtel, Neuchâtel, Switzerland., Mavridou DAI; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United Kingdom.; Department of Molecular Biosciences, University of Texas at Austin, Austin, United States.; John Ring LaMontagne Center for Infectious Diseases, University of Texas at Austin, Austin, United States.

Publikováno v: ELife [Elife] 2022 Jan 13; Vol. 11. Date of Electronic Publication: 2022 Jan 13.

Identification of Tse8 as a Type VI secretion system toxin from Pseudomonas aeruginosa that targets the bacterial transamidosome to inhibit protein synthesis in prey cells.

Autor: Nolan LM; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Cain AK; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.; Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia., Clamens T; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK., Furniss RCD; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK.; Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Manoli E; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK., Sainz-Polo MA; Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, Derio, Spain., Dougan G; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK., Albesa-Jové D; Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.; Instituto Biofisika (UPV/EHU, CSIC), Fundación Biofísica Bizkaia/Biofisika Bizkaia Fundazioa (FBB) and Departamento de Bioquímica y Biología Molecular, University of the Basque Country, Leioa, Spain., Parkhill J; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Mavridou DAI; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK. despoina.mavridou@austin.utexas.edu.; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA. despoina.mavridou@austin.utexas.edu., Filloux A; MRC Centre for Molecular Bacteriology and Infection (CMBI), Department of Life Sciences, Imperial College London, London, UK. a.filloux@imperial.ac.uk.

Publikováno v: Nature microbiology [Nat Microbiol] 2021 Sep; Vol. 6 (9), pp. 1199-1210. Date of Electronic Publication: 2021 Aug 19.