Consequences of splice variation on Secretin family G protein-coupled receptor function.

Autor: Furness SG, Wootten D, Christopoulos A, Sexton PM, Furness, Sebastian G B, Wootten, Denise, Christopoulos, Arthur, Sexton, Patrick M

Publikováno v: British Journal of Pharmacology; May2012, Vol. 166 Issue 1, p98-109, 12p

What determines the magnitude of cellular response for activation of G protein-coupled receptors?

Autor: Furness SG; a Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology , Monash University , Parkville , 3052 VIC , Australia., Wootten D; a Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology , Monash University , Parkville , 3052 VIC , Australia., Sexton PM; a Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology , Monash University , Parkville , 3052 VIC , Australia.

Publikováno v: Cell cycle (Georgetown, Tex.) [Cell Cycle] 2017 Mar 04; Vol. 16 (5), pp. 392-394. Date of Electronic Publication: 2017 Jan 05.

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.

Autor: Wootten D; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.) denise.wootten@monash.edu patrick.sexton@monash.edu., Reynolds CA; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.)., Koole C; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.)., Smith KJ; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.)., Mobarec JC; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.)., Simms J; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.)., Quon T; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.)., Coudrat T; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.)., Furness SG; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.)., Miller LJ; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.)., Christopoulos A; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.)., Sexton PM; Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville, Victoria, Australia (D.W., C.K., T.Q., T.C., S.G.B.F., A.C., P.M.S.); School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, UK (C.A.R., K.J.S., J.C.M.); School of Life and Health Sciences, Aston University, Birmingham, UK (J.S.); and Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ (L.J.M.).

Publikováno v: Molecular pharmacology [Mol Pharmacol] 2016 Mar; Vol. 89 (3), pp. 335-47. Date of Electronic Publication: 2015 Dec 23.

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias.

Autor: Andreassen KV; Nordic Bioscience A/S, Herlev, Denmark., Hjuler ST; Nordic Bioscience A/S, Herlev, Denmark., Furness SG; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia., Sexton PM; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia., Christopoulos A; Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia., Nosjean O; Institut de Recherches Servier, Croissy-sur-Seine, France., Karsdal MA; Nordic Bioscience A/S, Herlev, Denmark., Henriksen K; Nordic Bioscience A/S, Herlev, Denmark.

Publikováno v: PloS one [PLoS One] 2014 Mar 18; Vol. 9 (3), pp. e92042. Date of Electronic Publication: 2014 Mar 18 (Print Publication: 2014).

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions.

Autor: Savage EE; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Wootten D, Christopoulos A, Sexton PM, Furness SG

Publikováno v: BioTechniques [Biotechniques] 2013 Apr; Vol. 54 (4), pp. 217-21.