Restoration of virulence in the attenuated Candid#1 vaccine virus requires reversion at both positions 168 and 427 in the envelope glycoprotein GPC.

Autor: Nunberg JH; Montana Biotechnology Center, University of Montana, Missoula, Montana, USA., Westover JB; Department of Animal Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.; Institute for Antiviral Research, Utah State University, Logan, Utah, USA., York J; Montana Biotechnology Center, University of Montana, Missoula, Montana, USA., Jung KH; Department of Animal Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.; Institute for Antiviral Research, Utah State University, Logan, Utah, USA., Bailey KW; Department of Animal Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.; Institute for Antiviral Research, Utah State University, Logan, Utah, USA., Boardman KM; Department of Animal Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.; Institute for Antiviral Research, Utah State University, Logan, Utah, USA., Li M; Department of Animal Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.; Institute for Antiviral Research, Utah State University, Logan, Utah, USA., Furnell RS; Department of Animal Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.; Institute for Antiviral Research, Utah State University, Logan, Utah, USA., Wasson SR; Department of Animal Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.; Institute for Antiviral Research, Utah State University, Logan, Utah, USA., Murray JS; Department of Animal Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.; Institute for Antiviral Research, Utah State University, Logan, Utah, USA., Kaundal R; Department of Plants, Soils, and Climate, Utah State University, Logan, Utah, USA.; Center for Integrated BioSystems, Utah State University, Logan, Utah, USA., Thomas AJ; Department of Animal Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.; Center for Integrated BioSystems, Utah State University, Logan, Utah, USA., Gowen BB; Department of Animal Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.; Institute for Antiviral Research, Utah State University, Logan, Utah, USA.

Publikováno v: Journal of virology [J Virol] 2024 Apr 16; Vol. 98 (4), pp. e0011224. Date of Electronic Publication: 2024 Mar 20.