Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

Autor: Jones, SE, Lane, JM, Wood, AR, van Hees, VT, Tyrrell, J, Beaumont, RN, Jeffries, AR, Dashti, HS, Hillsdon, M, Ruth, KS, Tuke, MA, Yaghootkar, H, Sharp, SA, Jie, YJ, Thompson, WD, Harrison, JW, Dawes, A, Byrne, EM, Tiemeier, Henning, Allebrandt, KV, Bowden, J, Ray, DW, Freathy, RM, Murray, A, Mazzotti, DR, Gehrman, PR, Lawlor, DA, Frayling, TM, Rutter, MK, Hinds, DA, Saxena, R, Weedon, MN, Agee, M, Alipanahi, B, Auton, A, Bell, RK, Bryc, K, Elson, SL, Fontanillas, P, Furlotte, NA, Huber, KE, Kleinman, A, Litterman, NK, McCreight, JC, McIntyre, MH, Mountain, JL, Noblin, ES, Northover, CAM, Pitts, SJ, Sathirapongsasuti, JF, Sazonova, OV, Shelton, JF, Shringarpure, S, Tian, C, Tung, JY, Vacic, V, Wilson, CH

Publikováno v: Nature Communications, 10:343. Nature Publishing Group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::6a0d6d8238cb2004d7e6f9a61864f37f
https://pure.eur.nl/en/publications/8dac0919-e9fa-43b2-aad6-18890b4439f0

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

Autor: Tedja, MS, Wojciechowski, R, Hysi, PG, Eriksson, N, Furlotte, NA, Verhoeven, VJM, Iglesias, AI, Meester-Smoor, MA, Tompson, SW, Fan, Q, Khawaja, AP, Cheng, C-Y, Höhn, R, Yamashiro, K, Wenocur, A, Grazal, C, Haller, T, Metspalu, A, Wedenoja, J, Jonas, JB, Wang, YX, Xie, J, Mitchell, P, Foster, PJ, Klein, BEK, Klein, R, Paterson, AD, Hosseini, SM, Shah, RL, Williams, C, Teo, YY, Tham, YC, Gupta, P, Zhao, W, Shi, Y, Saw, W-Y, Tai, E-S, Sim, XL, Huffman, JE, Polašek, O, Hayward, C, Bencic, G, Rudan, I, Wilson, JF, Consortium, Cream, Team, 23Andme Research, Consortium, Uk Biobank Eye And Vision, Joshi, PK, Tsujikawa, A, Matsuda, F, Whisenhunt, KN, Zeller, T, Van Der Spek, PJ, Haak, R, Meijers-Heijboer, H, Van Leeuwen, EM, Iyengar, SK, Lass, JH, Hofman, A, Rivadeneira, F, Uitterlinden, AG, Vingerling, JR, Lehtimäki, T, Raitakari, OT, Biino, G, Concas, MP, Schwantes-An, T-H, Igo, RP, Cuellar-Partida, G, Martin, NG, Craig, JE, Gharahkhani, P, Williams, KM, Nag, A, Rahi, JS, Cumberland, PM, Delcourt, C, Bellenguez, C, Ried, JS, Bergen, AA, Meitinger, T, Gieger, C, Wong, TY, Hewitt, AW, Mackey, DA, Simpson, CL, Pfeiffer, N, Pärssinen, O, Baird, PN, Vitart, V, Amin, N, Van Duijn, CM, Bailey-Wilson, JE, Young, TL, Saw, S-M, Stambolian, D, Macgregor, S, Guggenheim, JA, Tung, JY, Hammond, CJ, Klaver, CCW

Publikováno v: Nature Genetics, 50(6), 834-848. Nature Publishing Group
CREAM Consortium 2018, ' Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error ', Nature Genetics, vol. 50, no. 6, pp. 834-848 . https://doi.org/10.1038/s41588-018-0127-7
the 23 and Me Research Team & Tedja, M S 2018, ' Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error ', Nature Genetics, vol. 50, no. 6, pp. 834-848 . https://doi.org/10.1038/s41588-018-0127-7
Nature Genetics, 50, 834-848
Nature genetics
Tedja, M S, Wojciechowski, R, Hysi, P, Eriksson, N, Furlotte, N A, Verhoeven, V J M, Iglesias, A I, Meester-Smoor, M A, Khawaja, A P, Cheng, C Y, Horn, R, Yamashiro, K, Wenocur, A, Grazal., C, Haller, T, Metspalu, A, Wedenoja, J, Jonas, J B, Wang, Y X, Mitchell, P, Hammond, C, Klaver, C C W, Consortium, T CREAM, Research Team & Eye and Vision Consortium, UK B 2018, ' Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error ', Nature Genetics, vol. 50, no. 6, pp. 834-848 . https://doi.org/10.1038/s41588-018-0127-7
Tedja, M S, Wojciechowski, R, Hysi, P G, Eriksson, N, Furlotte, N A, Verhoeven, V J M, Iglesias, A I, Meester-Smoor, M A, Tompson, S W, Fan, Q, Khawaja, A P, Cheng, C-Y, Höhn, R, Yamashiro, K, Wenocur, A, Grazal, C, Haller, T, Metspalu, A, Wedenoja, J, Jonas, J B, Wang, Y X, Xie, J, Mitchell, P, Foster, P J, Klein, B E K, Klein, R, Paterson, A D, Hosseini, S M, Shah, R L, Williams, C, Teo, Y Y, Tham, Y C, Gupta, P, Zhao, W, Shi, Y, Saw, W-Y, Tai, E-S, Sim, X L, Huffman, J E, Polašek, O, Hayward, C, Bencic, G, Rudan, I, Wilson, J F, Joshi, P K, Tsujikawa, A, Matsuda, F, Whisenhunt, K N & Zeller, T & Vitart, V 2018, ' Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error ', Nature Genetics, vol. 50, pp. 834-848 . https://doi.org/10.1038/s41588-018-0127-7
Nature Genetics, 50, 6, pp. 834-848
Nat. Genet. 50, 834-848 (2018)
Nature Genetics
CREAM, 23andMe Research Team, UK Biobank Eye and Vision Consortium, Aslam, T M & Bishop, P N 2018, ' Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error ', Nature Genetics, vol. 50, no. 6, pp. 834-848 . https://doi.org/10.1038/s41588-018-0127-7
Nature genetics, 50(6), 834-848. Nature Publishing Group

Skin affections after sulfur mustard (SM) exposure include erythema, blister formation and severe inflammation. An antidote or specific therapy does not exist. Anti-inflammatory compounds as well as substances counteracting SM-induced cell death are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793d48fb4f3df67932526ed5a953b5b4
https://pure.knaw.nl/portal/en/publications/67984a46-b4c9-4c16-818c-32a0935f3046

Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.

Autor: Schormair B; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. barbara.schormair@helmholtz-munich.de.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany. barbara.schormair@helmholtz-munich.de., Zhao C; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Bell S; Department of Oncology, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK., Didriksen M; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark., Nawaz MS; deCODE Genetics/Amgen, Reykjavik, Iceland., Schandra N; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Stefani A; Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Högl B; Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Dauvilliers Y; Sleep-Wake Disorders Center, Department of Neurology, Hôpital Gui-de-Chauliac, CHU Montpellier, Institut des Neurosciences de Montpellier, INSERM, Université de Montpellier, Montpellier, France., Bachmann CG; SomnoDiagnostics, Osnabrück, Germany.; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany., Kemlink D; Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic., Sonka K; Department of Neurology and Centre of Clinical Neuroscience, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic., Paulus W; Department of Neurology, Ludwig Maximilians University Munich, Munich, Germany., Trenkwalder C; Paracelsus-Elena-Klinik, Kassel, Germany.; Department of Neurosurgery, University Medical Center Göttingen, Göttingen, Germany., Oertel WH; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Department of Neurology, Philipps-University Marburg, Marburg, Germany., Hornyak M; Neuropsychiatry Centre Erding/München, Erding, Germany., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Metspalu A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Hadjigeorgiou GM; Department of Neurology, Nicosia General Hospital Medical School, University of Cyprus, Nicosia, Cyprus., Polo O; Bragée ME/CFS Center, Stockholm, Sweden., Fietze I; Department of Pulmonology, Center of Sleep Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany., Ross OA; Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA., Wszolek ZK; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Ibrahim A; Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Bergmann M; Sleep Disorders Clinic, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Kittke V; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Harrer P; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany., Dowsett J; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Chenini S; Sleep-Wake Disorders Center, Department of Neurology, Hôpital Gui-de-Chauliac, CHU Montpellier, Institut des Neurosciences de Montpellier, INSERM, Université de Montpellier, Montpellier, France., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Pedersen OB; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Topholm Bruun M; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Nielsen KR; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Soranzo N; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Human Genetics, the Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Ouwehand WH; Department of Haematology, University of Cambridge, Cambridge, UK.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, UK.; Department of Haematology, University College London Hospitals, London, UK., Roberts DJ; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Radcliffe Department of Medicine and National Health Service Blood and Transplant, Oxford, UK.; Department of Haematology and BRC Haematology Theme, Churchill Hospital, Headington, Oxford, UK., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Department of Human Genetics, the Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Burchell B; Magdalene College, Cambridge, UK., Furlotte NA; 23andMe, Inc., Sunnyvale, CA, USA., Nandakumar P; 23andMe, Inc., Sunnyvale, CA, USA., Earley CJ; Center for Restless Legs Syndrome, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., Ondo WG; Department of Neurology, Methodist Neurological Institute, Weill Cornell Medical School, Houston, TX, USA., Xiong L; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Desautels A; Centre d'Études Avancées en Médecine du Sommeil, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.; Department of Neurosciences, Université de Montréal, Montreal, Quebec, Canada., Perola M; Clinical and Molecular Metabolism Research Program (CAMM), Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Department of Public Health and Welfare, National Institute for Health and Welfare, Helsinki, Finland., Vodicka P; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Science of Czech Republic, Prague, Czech Republic.; First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.; Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic., Dina C; L'institut du thorax, CNRS, INSERM, Nantes Université, Nantes, France., Stoll M; Department of Genetic Epidemiology, Institute for Human Genetics, University of Münster, Münster, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Lieb W; PopGen Biobank and Institute of Epidemiology, Christian Albrechts University Kiel, Kiel, Germany., Stewart AFR; John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada., Shah SH; Department of Medicine, Duke University School of Medicine, Durham, NC, USA.; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA., Gieger C; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Research Center for Cardiovascular Disease (DZHK), partner site Munich Heart Alliance, Hannover, Germany.; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany., Rye DB; Department of Neurology, Emory University, Atlanta, GA, USA., Rouleau GA; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Stefansson H; deCODE Genetics/Amgen, Reykjavik, Iceland., Ullum H; Statens Serum Institute, Copenhagen, Denmark., Stefansson K; deCODE Genetics/Amgen, Reykjavik, Iceland., Hinds DA; 23andMe, Inc., Sunnyvale, CA, USA., Di Angelantonio E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Health Data Science Research Centre, Fondazione Human Technopole, Milan, Italy., Oexle K; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Neurogenetic Systems Analysis Group, Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Winkelmann J; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; German Center for Mental Health (DZPG), partner site Munich-Augsburg, Munich-Augsburg, Germany.

Publikováno v: Nature genetics [Nat Genet] 2024 Jun; Vol. 56 (6), pp. 1090-1099. Date of Electronic Publication: 2024 Jun 05.

Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color.

Autor: Simcoe M; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.; Department of Ophthalmology, King's College London, London, UK., Valdes A; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.; Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK., Liu F; Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Furlotte NA; 23andMe Inc., Sunnyvale, CA, USA., Evans DM; University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Hemani G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences Bristol Medical School University of Bristol, Bristol, UK., Ring SM; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences Bristol Medical School University of Bristol, Bristol, UK., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences Bristol Medical School University of Bristol, Bristol, UK., Duffy DL; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Zhu G; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Gordon SD; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Vuckovic D; Department of Medical Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy.; Epidemiology and Biostatistics Department, Faculty of Medicine, School of Public Health, Imperial College London, London, UK., Girotto G; Department of Medical Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Sala C; Division of Genetics of Common Disorders, S. Raffaele Scientific Institute, Milan, Italy., Catamo E; Department of Medical Sciences, University of Trieste, Trieste, Italy., Concas MP; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Brumat M; Department of Medical Sciences, University of Trieste, Trieste, Italy., Gasparini P; Department of Medical Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Toniolo D; Division of Genetics of Common Disorders, S. Raffaele Scientific Institute, Milan, Italy., Cocca M; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Robino A; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Yazar S; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia., Hewitt A; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia.; Centre for Eye Research Australia, University of Melbourne, Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.; School of Medicine, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia., Wu W; Department of Epidemiology, Fairbanks School of Public Health, Indiana University, and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA., Kraft P; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Hammond CJ; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK.; Department of Ophthalmology, King's College London, London, UK., Shi Y; Singapore Eye Research Institute, Singapore National Eye Center, Singapore., Chen Y; Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China., Zeng C; Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China., Klaver CCW; Department of Ophthalmology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, Netherlands., Uitterlinden AG; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands., Hamer MA; Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands., van Duijn CM; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Nijsten T; Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands., Han J; Department of Epidemiology, Fairbanks School of Public Health, Indiana University, and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, USA., Mackey DA; Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Center, Singapore.; Duke-NUS Medical School, Singapore., Hinds DA; 23andMe Inc., Sunnyvale, CA, USA., Spector TD; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK., Kayser M; Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands. pirro.hysi@kcl.ac.uk., Hysi PG; Department of Twins Research and Genetic Epidemiology, King's College London, London, UK. pirro.hysi@kcl.ac.uk.; Department of Ophthalmology, King's College London, London, UK.

Publikováno v: Science advances [Sci Adv] 2021 Mar 10; Vol. 7 (11). Date of Electronic Publication: 2021 Mar 10 (Print Publication: 2021).

Direct-to-consumer genetic testing for factor V Leiden and prothrombin 20210G>A: the consumer experience.

Autor: Elson SL; 23andMe, Inc, Sunnyvale, CA, USA., Furlotte NA; 23andMe, Inc, Sunnyvale, CA, USA., Hromatka BS; 23andMe, Inc, Sunnyvale, CA, USA., Wilson CH; 23andMe, Inc, Sunnyvale, CA, USA., Mountain JL; 23andMe, Inc, Sunnyvale, CA, USA., Rowbotham HM; 23andMe, Inc, Sunnyvale, CA, USA., Varga EA; Nationwide Children's Hospital, Columbus, OH, USA., Francke U; 23andMe, Inc, Sunnyvale, CA, USA.; Department of Genetics, Stanford University Stanford, CA, USA.

Publikováno v: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2020 Nov; Vol. 8 (11), pp. e1468. Date of Electronic Publication: 2020 Sep 16.