ePoster Vascular Discovery 2020 MDG.pdf

Autor: De Giorgi, Marco, Jarrett, Kelsey, Burton, Jason, Doerfler, Alexandria, Hurley, Ayrea, Li, Ang, Hsu, Rachel, Furgurson, Mia N., Han, Jun, Borchers, Christoph H., R. Lagor, William

Hmg-CoA Reductase (Hmgcr) catalyzes the conversion of Hmg-CoA to mevalonate, which is the rate-limiting step in the cholesterol biosynthetic pathway. Hmgcr is the target of statins, which are the front line therapy for hypercholesterolemia. In additi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e173545ea1e62d96a73d7ea519b8405

ASGCT slides MDG May4.pptx

Autor: De Giorgi, Marco, Hurley, Ayrea, Doerfler, Alexandria, Furgurson, Mia N., Chuecos, Marcel, Hyde, Sarah, Chickering, Tyler, Lefebvre, Stephanie, Qin, June, Bissig, Karl-Dimiter, Castoreno, Adam B., Jadhav, Vasant, R. Lagor, William

Targeted integration of therapeutic transgenes into a common genomic site could be used to treat a broad range of liver diseases. Recently, we showed that the Apolipoprotein A1 (Apoa1) locus could be targeted with adeno-associated viral (AAV) deliver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3661111ce2095c6628c27b04d94885

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In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.

Autor: De Giorgi M; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Park SH; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Castoreno A; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Cao M; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Hurley A; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Saxena L; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Chuecos MA; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA., Walkey CJ; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Doerfler AM; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Furgurson MN; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Ljungberg MC; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.; Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA., Patel KR; Department of Pathology, Texas Children's Hospital, Houston, TX 77030, USA., Hyde S; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Chickering T; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Lefebvre S; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Wassarman K; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Miller P; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Qin J; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Schlegel MK; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Zlatev I; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Li RG; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Kim J; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Martin JF; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Heart Institute, Houston, TX 77030, USA., Bissig KD; Department of Pediatrics, Alice and Y. T. Chen Center for Genetics and Genomics, Division of Medical Genetics, Duke University, Durham, NC 27710, USA., Jadhav V; Alnylam Pharmaceuticals Inc, 675 W Kendall St, Cambridge, MA 02142, USA., Bao G; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Lagor WR; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 29. Date of Electronic Publication: 2023 Jul 29.