Výsledky vyhledávání - "Funsho Ogunshola"

Akademický článek

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes

Autor: Bongiwe Mahlobo, Faatima Laher, Werner Smidt, Funsho Ogunshola, Trevor Khaba, Thandeka Nkosi, Anele Mbatha, Thandekile Ngubane, Krista Dong, Ismail Jajbhay, Johan Pansegrouw, Zaza M. Ndhlovu

Publikováno v: BMC Immunology, Vol 23, Iss 1, Pp 1-19 (2022)

Abstract Background HIV eradication efforts have been unsuccessful partly due to virus persistence in immune sanctuary sites such as germinal centres within lymph node (LN) tissues. Recent evidence suggests that LNs harbour a novel subset of regulato

Externí odkaz: https://doaj.org/article/44ea8b47cf83442abec00ae4b385cecd

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Akademický článek

CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection

Autor: Omolara O. Baiyegunhi, Jaclyn Mann, Trevor Khaba, Thandeka Nkosi, Anele Mbatha, Funsho Ogunshola, Caroline Chasara, Nasreen Ismail, Thandekile Ngubane, Ismail Jajbhay, Johan Pansegrouw, Krista L. Dong, Bruce D. Walker, Thumbi Ndung’u, Zaza M. Ndhlovu

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Despite antiretroviral therapy, HIV often persists in tissue sanctuary sites. In this work, authors investigate HIV persistence and T cell responses in lymph node biopsies obtained from individuals who initiated antiretroviral therapy in Fiebig stage

Externí odkaz: https://doaj.org/article/50e73a5e9c94475094bccd50e686c5cb

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Akademický článek

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

Autor: Funsho Ogunshola, Gursev Anmole, Rachel L. Miller, Emily Goering, Thandeka Nkosi, Daniel Muema, Jaclyn Mann, Nasreen Ismail, Denis Chopera, Thumbi Ndung’u, Mark A. Brockman, Zaza M Ndhlovu

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Closely related HLA alleles presenting similar HIV-1 epitopes can be associated with variable clinical outcome. Here the authors report their findings on CD8+ T cell responses to the HIV-1 Gag-p24 TL9 immunodominant epitope in the context of closely

Externí odkaz: https://doaj.org/article/8b5dac89542c4c2da2cce8fc2d1bce1e

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CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection

Publikováno v: Nature Communications

HIV persistence in tissue sites despite ART is a major barrier to HIV cure. Detailed studies of HIV-infected cells and immune responses in native lymph node tissue environment is critical for gaining insight into immune mechanisms impacting HIV persi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8196a279d502566ae52aebebc6e664d6
https://pubmed.ncbi.nlm.nih.gov/35831418

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Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection

Autor: Thandeka Nkosi, Samuel W. Kazer, Funsho Ogunshola, Gursev Anmole, Krista L. Dong, Mark A. Brockman, Bruce D. Walker, Daniel M. Muema, Amber Moodley, Shayda A. Swann, Thumbi Ndung'u, Alex K. Shalek, Zaza M. Ndhlovu, Tarylee Reddy

Publikováno v: PMC

Sustained viremia after acute HIV infection is associated with profound CD4⁺ T cell loss and exhaustion of HIV-specific CD8⁺ T cell responses. To determine the impact of combination antiretroviral therapy (cART) on these processes, we examined th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95346b705c54b304965195035342dac6
https://doi.org/10.1126/scitranslmed.aau0528

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Frequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load

Autor: Bongiwe Ndlovu, Nasreen Ismail, Thumbi Ndung'u, Zaza M. Ndhlovu, Bruce D. Walker, Omolara Baiyegunhi, Funsho Ogunshola

Publikováno v: Journal of Virology

Despite decades of focused research, the field has yet to develop a prophylactic vaccine. In the RV144 vaccine trial, non-neutralizing antibody responses were identified as a correlate for prevention of HIV acquisition. However, factors that predict

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc62964d9c6773d0423817e7b52e0435
https://doi.org/10.1128/jvi.00659-18

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Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

Autor: Rachel L Miller, Denis Chopera, Daniel M. Muema, Funsho Ogunshola, Gursev Anmole, Zaza M. Ndhlovu, Nasreen Ismail, Thumbi Ndung'u, Emily Goering, Thandeka Nkosi, Mark A. Brockman, Jaclyn K. Mann

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Some closely related human leukocyte antigen (HLA) alleles are associated with variable clinical outcomes following HIV-1 infection despite presenting the same viral epitopes. Mechanisms underlying these differences remain unclear but may be due to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2827381aa88c31602db24ae5fdf60cc
https://pubmed.ncbi.nlm.nih.gov/30479346

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