Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder

Autor: Valerie Treyer, Simon M. Ametamey, Gregor Hasler, Susanne Rösner, Alfred Buck, Funda Akkus, Anass Johayem, Yoan Mihov, Smeralda Senn

Publikováno v: Translational Psychiatry, Vol 8, Iss 1, Pp 1-8 (2018)
Akkus, Funda; Mihov, Yoan Venceslavov; Treyer, V; Ametamey, SM; Johayem, A; Senn, S; Rösner, S; Buck, A; Hasler, Gregor (2018). Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder. Translational psychiatry, 8(1), p. 17. Nature Publishing Group 10.1038/s41398-017-0066-6
Translational Psychiatry, 8 (1)
Translational Psychiatry

Glutamate signaling plays a major role in addiction. Preclinical research strongly suggests an implication of G-protein-coupled metabotropic glutamate receptor subtype 5 (mGluR5) in nicotine addiction and alcohol use disorder. In humans, smoking is r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f3494435ff3391aa3d25efdbe995d3
http://link.springer.com/article/10.1038/s41398-017-0066-6

The role of metabotropic glutamate receptor 5 in the pathogenesis of mood disorders and addiction: combining preclinical evidence with human Positron Emission Tomography (PET) studies

Autor: Sylvia Terbeck, Gregor Hasler, Funda Akkus, L. P. Chesterman

Publikováno v: Frontiers in Neuroscience
Terbeck, Sylvia; Akkus, Funda; Chesterman, Laurence P; Hasler, Gregor (2015). The role of metabotropic glutamate receptor 5 in the pathogenesis of mood disorders and addiction: combining preclinical evidence with human Positron Emission Tomography (PET) studies. Frontiers in neuroscience, 9, p. 86. Frontiers Research Foundation 10.3389/fnins.2015.00086
Frontiers in Neuroscience, Vol 9 (2015)

In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction. Specifically, we will describe mGluR5 studies in humans that em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80d5a4deffb67b62c639564b5be69dd
https://pubmed.ncbi.nlm.nih.gov/25852460

Metabotropic glutamate receptor 5 binding in patients with obsessive-compulsive disorder

Autor: Cyrill Burger, Alfred Buck, Judit Sovago, Funda Akkus, Michael Rufer, Baltazar Gomez Mancilla, Sylvia Terbeck, Gregor Hasler, Simon M. Ametamey, A. Johayem, Valerie Treyer

Publikováno v: Akkus, Funda; Terbeck, Sylvia; Ametamey, Simon M; Rufer, Michael; Treyer, Valerie; Burger, Cyrill; Johayem, Anass; Mancilla, Baltazar Gomez; Sovago, Judit; Buck, Alfred; Hasler, Gregor (2014). Metabotropic glutamate receptor 5 binding in patients with obsessive-compulsive disorder. International journal of neuropsychopharmacology, 17(12), pp. 1915-1922. Cambridge University Press 10.1017/S1461145714000716

Obsessive-compulsive disorder (OCD) is a disabling, mostly chronic, psychiatric condition with significant social and economic impairments and is a major public health issue. However, numerous patients are resistant to currently available pharmacolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb04f154405bbe3c16d7adf9f040aa1
https://boris.unibe.ch/53487/1/Akkus_Hasler_2014_mGluR5_OCD.pdf

MGluR5 binding as a specific biomarker for nicotine dependence and relapse in humans

Autor: Yoan Mihov, Gregor Hasler, A. Johayem, S. Kraemer, Valerie Treyer, Adrienne Müller Herde, Funda Akkus, F. Buck, Simon M. Ametamey

Publikováno v: European Neuropsychopharmacology. 26:S126

Nicotine addiction is a major public health problem and increases the risk for various psychiatric conditions, including depression and schizophrenia. On a neurophysiological level, it is associated with aberrant glutamate activity. We recently showe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71842a7cb138c90f5092c50e450d11a6
https://doi.org/10.1016/s0924-977x(16)30903-8