Zobrazeno 1 - 10
of 793
pro vyhledávání: '"Functional assays"'
Autor:
Lucie Thorel, Jordane Divoux, Justine Lequesne, Guillaume Babin, Pierre-Marie Morice, Romane Florent, Guillaume Desmartin, Lucie Lecouflet, Chloé Marde Alagama, Alexandra Leconte, Bénédicte Clarisse, Mélanie Briand, Roman Rouzier, Léopold Gaichies, Sandrine Martin-Françoise, Jean-François Le Brun, Christophe Denoyelle, Nicolas Vigneron, Corinne Jeanne, Cécile Blanc-Fournier, Raphaël Leman, Dominique Vaur, Martin Figeac, Matthieu Meryet-Figuiere, Florence Joly, Louis-Bastien Weiswald, Laurent Poulain, Enora Dolivet
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Ovarian cancer is the first cause of death from gynecological malignancies mainly due to development of chemoresistance. Despite the emergence of PARP inhibitors, which have revolutionized the therapeutic management of some of the
Externí odkaz:
https://doaj.org/article/088b590c02d14c37987eaddfddc2217f
Autor:
Lucía del Pino Molina, Keren Reche Yebra, Yolanda Soto Serrano, Álvaro Clemente Bernal, Carmen L. Avendaño-Monje, J. Gonzalo Ocejo-Vinyals, Rebeca Rodríguez Pena, Eduardo López Granados
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe use of next-generation sequencing in inborn errors of immunity (IEI) has considerably increased the identification of novel gene variants, many of which are identified in patients without the described clinical phenotype or with variant
Externí odkaz:
https://doaj.org/article/57b54d68b88b426487bdc3bb0eda2b84
Autor:
Jenevieve Hara, Maaike Vercauteren, Sébastjen Schoenaers, Colin R. Janssen, Ronny Blust, Jana Asselman, Raewyn M. Town
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 286, Iss , Pp 117255- (2024)
Bivalve hemocytes, particularly granulocytes and hyalinocytes, play a crucial role in cell-mediated immunity. However, their interactions with aged plastic particles, exhibiting altered properties that more closely resemble those in natural environme
Externí odkaz:
https://doaj.org/article/395a178cc6d44c46b24d202cfca7fd36
Autor:
Mari Palviainen, Johanna Puutio, Rikke Halse Østergaard, Johannes A. Eble, Katariina Maaninka, Umar Butt, Joseph Ndika, Otto K. Kari, Masood Kamali‐Moghaddam, Kasper Kjaer‐Sorensen, Claus Oxvig, Ana M. Aransay, Juan M. Falcon‐Perez, Antonio Federico, Dario Greco, Saara Laitinen, Yuya Hayashi, Pia R.‐M. Siljander
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 10, Pp n/a-n/a (2024)
Abstract Renowned for their role in haemostasis and thrombosis, platelets are also increasingly recognized for their contribution in innate immunity, immunothrombosis and inflammatory diseases. Platelets express a wide range of receptors, which allow
Externí odkaz:
https://doaj.org/article/d1bacf0104064fd49990f7e4e0293c8c
Autor:
Azzeddine Tahiat, Reda Belbouab, Abdelghani Yagoubi, Saliha Hakem, Faiza Fernini, Malika Keddari, Hayet Belhadj, Souad Touri, Samira Aggoune, Jennifer Stoddard, Julie Niemela, Farida Zerifi, Souhila Melzi, Rawda Aboura, Amina Saad-Djaballah, Yacine Ferhani, Abdalbasset Ketfi, Hassen Messaoudi, Tahar Bencharif Madani, Zouleikha Benhacine, Abdelhak Dehimi, Kamelia Okka, Fairouz Amroune, Meriem Fellahi, Chafa Bendahmane, Radia Khoulani, Asma Oukil, Asma Soufane, Imene Bourelaf, Chahynez Boubidi, Nadia Boukhenfouf, Mohamed Amine Ifri, Noureddine Khelafi, Houda Boudiaf, Tahar Khelifi Touhami, Fethi Meçabih, Malika Boucelma, Amara Zelaci, Ourida Gacem, Mohamed Samir Ladj, Azzedine Mekki, Nadia Bensaadi, Malika Benhalima, Zoulikha Zeroual, Belkacem Bioud, Mustapha Benameur, Rachid Bouhdjila, Zahir Bouzerar, Ouardia Ibsaine, Hachemi Maouche, Leila Kedji, Leila Smati, Rachida Boukari, Claude Lambert, Sergio D. Rosenzweig, Luigi D. Notarangelo, Kamel Djenouhat
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
PurposeIn this study, we retrospectively reviewed the use of flow cytometry (FCM) in the diagnosis of inborn errors of immunity (IEIs) at a single center in Algeria. Sharing insights into our practical experience, we present FCM based diagnostic appr
Externí odkaz:
https://doaj.org/article/0373dc062c034461aab9cf65179e134c
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is a rare, combined immunodeficiency disease predominantly caused by gain-of-function variants in the CXCR4 gene that typically results in truncation of the carboxyl terminus of
Externí odkaz:
https://doaj.org/article/33a4399d5701453fb24be25e56262870
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/ea8ccd7d841840ddbf7be63eb0a4d03b
Autor:
Jelena Dinić, Sofija Jovanović Stojanov, Miodrag Dragoj, Marija Grozdanić, Ana Podolski-Renić, Milica Pešić
Publikováno v:
Life, Vol 14, Iss 9, p 1142 (2024)
The field of oncology has witnessed remarkable progress in personalized cancer therapy. Functional precision medicine has emerged as a promising avenue for achieving superior treatment outcomes by integrating omics profiling and sensitivity testing o
Externí odkaz:
https://doaj.org/article/56e2025699b04560acc69597f2f68d40
Autor:
Shuoshuo Wei, Yanying Li, Wanling Yang, Shuxiong Chen, Fupeng Liu, Mei Zhang, Bo Ban, Dongye He
Publikováno v:
Heliyon, Vol 10, Iss 6, Pp e28082- (2024)
KBG syndrome is a rare autosomal dominant condition characterized by multisystem developmental disorder, primarily caused by loss-of-function variants in ankyrin repeat domain-containing protein 11 (ANKRD11). Approximately 80 % of ANKRD11 variants as
Externí odkaz:
https://doaj.org/article/9017b69e67e74b76b156e3e1c86d5c3d
Autor:
Lucie Thorel, Pierre-Marie Morice, Hippolyte Paysant, Romane Florent, Guillaume Babin, Cécilia Thomine, Marion Perréard, Edwige Abeilard, Florence Giffard, Emilie Brotin, Christophe Denoyelle, Céline Villenet, Shéhérazade Sebda, Mélanie Briand, Florence Joly, Enora Dolivet, Didier Goux, Cécile Blanc-Fournier, Corinne Jeanne, Marie Villedieu, Matthieu Meryet-Figuiere, Martin Figeac, Laurent Poulain, Louis-Bastien Weiswald
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background In the era of personalized medicine, the establishment of preclinical models of cancer that faithfully recapitulate original tumors is essential to potentially guide clinical decisions. Methods We established 7 models [4 cell line
Externí odkaz:
https://doaj.org/article/fcc6d93e6e1648e1ac7194108ee99a59