Zobrazeno 1 - 10
of 1 173
pro vyhledávání: '"Function and Dysfunction of the Nervous System"'
Autor:
Dilansu Guneykaya, Bilge Ugursu, Francesca Logiacco, Oliver Popp, Maria Almut Feiks, Niklas Meyer, Stefan Wendt, Marcus Semtner, Fatma Cherif, Christian Gauthier, Charlotte Madore, Zhuoran Yin, Özcan Çınar, Taner Arslan, Zoltan Gerevich, Philipp Mertins, Oleg Butovsky, Helmut Kettenmann, Susanne A. Wolf
Publikováno v:
Brain, Behavior, and Immunity. 111:61-75
Neuroligin-4 (NLGN4) loss-of-function mutations are associated with monogenic heritable autism spectrum disorder (ASD) and cause alterations in both synaptic and behavioral phenotypes. Microglia, the resident CNS macrophages, are implicated in ASD de
Autor:
Sean J. Pittock, Michael Barnett, Jeffrey L. Bennett, Achim Berthele, Jérôme de Sèze, Michael Levy, Ichiro Nakashima, Celia Oreja‐Guevara, Jacqueline Palace, Friedemann Paul, Carlo Pozzilli, Marcus Yountz, Kerstin Allen, Yasmin Mashhoon, Ho Jin Kim
Publikováno v:
Annals of Neurology. 93:1053-1068
OBJECTIVE: CHAMPION-NMOSD (NCT04201262) is a phase 3, open-label, externally controlled interventional study evaluating the efficacy and safety of the terminal complement inhibitor ravulizumab in adult patients with anti-aquaporin-4 antibody-positive
Publikováno v:
Molecular Therapy - Nucleic Acids. 31:494-511
With thousands of patients worldwide, CAPN3 c.550delA is the most frequent mutation causing severe, progressive, and untreatable limb girdle muscular dystrophy. We aimed to genetically correct this founder mutation in primary human muscle stem cells.
Autor:
Khodabandeh, Z., Rabbani, H., Ashtari, F., Zimmermann, H.G., Motamedi, S., Brandt, A.U., Paul, F., Kafieh, R.
BACKGROUND: Multiple sclerosis (MS) is one of the most prevalent chronic inflammatory diseases caused by demyelination and axonal damage in the central nervous system. Structural retinal imaging via optical coherence tomography (OCT) shows promise as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=mdc______med::04262e4e45568ce1d50418210bb91db2
http://edoc.mdc-berlin.de/23566/1/23566oa.pdf
http://edoc.mdc-berlin.de/23566/1/23566oa.pdf
Autor:
Sanetra, A M., Palus-Chramiec, K., Chrobok, L., Jeczmien-Lazur, J.S., Klich, J.D., Lewandowski, M.H.
A relatively new pharmacological target in obesity treatment has been the preproglucagon (PPG) signalling, predominantly with glucagon-like peptide (GLP) 1 receptor agonists. As far as the PPG role within the digestive system is well recognised, its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=mdc______med::a8483d6b48548f024f703f6e4e495831
http://edoc.mdc-berlin.de/23523/2/23523suppl.xlsx
http://edoc.mdc-berlin.de/23523/2/23523suppl.xlsx
Autor:
Rosiewicz, K.S., Muinjonov, B., Kunz, S., Radbruch, H., Chen, J., Jüttner, R., Kerkering, J., Ucar, J., Crowley, T., Wielockx, B., Paul, F., Alisch, M., Siffrin, V.
Astrocytes constitute the parenchymal border of the blood-brain barrier (BBB), modulate the exchange of soluble and cellular elements, and are essential for neuronal metabolic support. Thus, astrocytes critically influence neuronal network integrity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=mdc______med::4f3aefb80405e7c15972418a3c7e8c16
http://edoc.mdc-berlin.de/23339/1/23339oa.pdf
http://edoc.mdc-berlin.de/23339/1/23339oa.pdf
Autor:
Carl J. J. Herrmann, Ludger Starke, Jason M. Millward, Joseph Kuchling, Friedemann Paul, Thoralf Niendorf
Publikováno v:
Tomography
Volume 9
Issue 1
Pages: 299-314
Volume 9
Issue 1
Pages: 299-314
(1) Background: Radial RARE-EPI MRI facilitates simultaneous T2 and T2* mapping (2in1-RARE-EPI). With modest undersampling (R = 2), the speed gain of 2in1-RARE-EPI relative to Multi-Spin-Echo and Multi-Gradient-Recalled-Echo references is limited. Fu
Autor:
Dermot Harnett, Mateusz C. Ambrozkiewicz, Ulrike Zinnall, Alexandra Rusanova, Ekaterina Borisova, Amelie N. Drescher, Marta Couce-Iglesias, Gabriel Villamil, Rike Dannenberg, Koshi Imami, Agnieszka Münster-Wandowski, Beatrix Fauler, Thorsten Mielke, Matthias Selbach, Markus Landthaler, Christian M. T. Spahn, Victor Tarabykin, Uwe Ohler, Matthew L. Kraushar
Publikováno v:
Nature Structural and Molecular Biology
Translation modulates the timing and amplification of gene expression after transcription. Brain development requires uniquely complex gene expression patterns, but large-scale measurements of translation directly in the prenatal brain are lacking. W
Autor:
Harald Hefter, Dietmar Rosenthal, Alexander Jansen, Raphaela Brauns, Beyza Ürer, Hans Bigalke, Hans-Peter Hartung, Sven G. Meuth, John-Ih Lee, Philipp Albrecht, Sara Samadzadeh
Publikováno v:
Journal of Neurology. 270:788-796
Background For many indications, BoNT/A is repetitively injected with the risk of developing neutralizing antibodies (NABs). Therefore, it is important to analyze whether there is a difference in antigenicity between the different licensed BoNT/A pre
Autor:
Biniam M. Bekele, Verena Schöwel‐Wolf, Janine Kieshauer, Andreas Marg, Andreas Busjahn, Sarah Davis, Gayle Nugent, Anne‐Karoline Ebert, Simone Spuler
Publikováno v:
Animal Models and Experimental Medicine. 5:453-460
BACKGROUND: The aim of the study was to demonstrate the efficacy of human muscle stem cells (MuSCs) isolated using innovative technology in restoring internal urinary sphincter function in a preclinical animal model. METHODS: Colonies of pure human M