Výsledky vyhledávání - "Fumiyuki Hatanaka"

Akademický článek

Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

Autor: Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, Jingting Yu, Yuta Takahashi, Akihisa Sakamoto, Javier Prieto, Maxim Shokhirev, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract Defect in the SMN1 gene causes spinal muscular atrophy (SMA), which shows loss of motor neurons, muscle weakness and atrophy. While current treatment strategies, including small molecules or viral vectors, have shown promise in improving mot

Externí odkaz: https://doaj.org/article/10b9828b196546fa8165e5097af9a12a

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Akademický článek

Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium

Autor: Tomoaki Hishida, Eric Vazquez-Ferrer, Yuriko Hishida-Nozaki, Yuto Takemoto, Fumiyuki Hatanaka, Kei Yoshida, Javier Prieto, Sanjeeb Kumar Sahu, Yuta Takahashi, Pradeep Reddy, David D. O’Keefe, Concepcion Rodriguez Esteban, Paul S. Knoepfler, Estrella Nuñez Delicado, Antoni Castells, Josep M. Campistol, Ryuji Kato, Hiroshi Nakagawa, Juan Carlos Izpisua Belmonte

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewa

Externí odkaz: https://doaj.org/article/31205045cd044c04b4a97467e784b2c0

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Akademický článek

αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

Publikováno v: Protein & Cell, Vol 11, Iss 3, Pp 219-226 (2020)

Externí odkaz: https://doaj.org/article/37783dd84b5348adb38d66fcf9ff720f

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Akademický článek

Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway

Publikováno v: Protein & Cell, Vol 10, Iss 7, Pp 485-495 (2019)

Abstract Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. Here, we demonstrate that SOX2+ foregut epithelial cells are prone to onc

Externí odkaz: https://doaj.org/article/650bfe1468004174b4f346e6bcc81813

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Akademický článek

A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.

Autor: Akihiro Goriki, Fumiyuki Hatanaka, Jihwan Myung, Jae Kyoung Kim, Takashi Yoritaka, Shintaro Tanoue, Takaya Abe, Hiroshi Kiyonari, Katsumi Fujimoto, Yukio Kato, Takashi Todo, Akio Matsubara, Daniel Forger, Toru Takumi

Publikováno v: PLoS Biology, Vol 12, Iss 4, p e1001839 (2014)

Circadian rhythms are controlled by a system of negative and positive genetic feedback loops composed of clock genes. Although many genes have been implicated in these feedback loops, it is unclear whether our current list of clock genes is exhaustiv

Externí odkaz: https://doaj.org/article/3fbbaabf77d64dd197bfbf0eb6df3720

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Akademický článek

Characterization and modeling of intermittent locomotor dynamics in clock gene-deficient mice.

Autor: Toru Nakamura, Toru Takumi, Atsuko Takano, Fumiyuki Hatanaka, Yoshiharu Yamamoto

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58884 (2013)

The scale-invariant and intermittent dynamics of animal behavior are attracting scientific interest. Recent findings concerning the statistical laws of behavioral organization shared between healthy humans and wild-type mice (WT) and their alteration

Externí odkaz: https://doaj.org/article/78bbc9198a3a4f9193f17b5e1e416712

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Akademický článek

Decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling.

Autor: Kota Tamada, Shozo Tomonaga, Fumiyuki Hatanaka, Nobuhiro Nakai, Keizo Takao, Tsuyoshi Miyakawa, Jin Nakatani, Toru Takumi

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15126 (2010)

Autism spectrum disorders (ASDs) have garnered significant attention as an important grouping of developmental brain disorders. Recent genomic studies have revealed that inherited or de novo copy number variations (CNVs) are significantly involved in

Externí odkaz: https://doaj.org/article/bbe8e3d0432546138e38f9759f8c973b

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Akademický článek

Robust food anticipatory activity in BMAL1-deficient mice.

Autor: Julie S Pendergast, Wataru Nakamura, Rio C Friday, Fumiyuki Hatanaka, Toru Takumi, Shin Yamazaki

Publikováno v: PLoS ONE, Vol 4, Iss 3, p e4860 (2009)

Food availability is a potent environmental cue that directs circadian locomotor activity in rodents. Even though nocturnal rodents prefer to forage at night, daytime food anticipatory activity (FAA) is observed prior to short meals presented at a sc

Externí odkaz: https://doaj.org/article/826d754f69474a7db3883a7fc50a2cc4

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