Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Fumito Ichinose"'
Autor:
Christian L. Lino Cardenas, Wanlin Jiang, Lova P. Kajuluri, Kuldeep Singh, Katrina Ostrom, Rebecca Li, Francois Cherbonneau, Sophie Boerboom, Claire Birchenough, Kangsan Roh, Elizabeth L. Chou, Zarbafian Shahrooz, Christopher Nicholson, Adam L. Johnson, Sujin Lee, Fumito Ichinose, Donald B. Bloch, Sagar Nigwekar, Patrick T. Ellinor, Patricia Musolino, Mark E. Lindsay, Zhixun Dou, Clint L. Miller, Rajeev Malhotra
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108360- (2023)
Summary: Vascular calcification is a hallmark of atherosclerotic disease and serves as a strong predictor and risk factor for cardiovascular events. Growing evidence suggests that autophagy may play a protective role in early atherosclerosis. The pre
Externí odkaz:
https://doaj.org/article/dfcb03ed88384b2a8a1a620d55b76971
Autor:
Eiki Kanemaru, Yusuke Miyazaki, Eizo Marutani, Mariko Ezaka, Shunsaku Goto, Etsuo Ohshima, Donald B. Bloch, Fumito Ichinose
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102620- (2023)
Background: Delayed paraplegia is a devastating complication of thoracoabdominal aortic surgery. Hydrogen sulfide (H2S) was reported to be protective in a mouse model of spinal cord ischemia and the beneficial effect of H2S has been attributed to pol
Externí odkaz:
https://doaj.org/article/06b7312f1f15406480e26f73654ea379
Autor:
Fumiaki Nagashima, Yusuke Miyazaki, Eiki Kanemaru, Mariko Ezaka, Hiroaki Hara, Kei Sugiura, Sophie L. Boerboom, Katrina F. Ostrom, Wanlin Jiang, Donald B. Bloch, Fumito Ichinose, Eizo Marutani
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102562- (2023)
Externí odkaz:
https://doaj.org/article/243d721d9d384fad9667c5b4479e5399
Autor:
Eizo Marutani, Masanobu Morita, Shuichi Hirai, Shinichi Kai, Robert M. H. Grange, Yusuke Miyazaki, Fumiaki Nagashima, Lisa Traeger, Aurora Magliocca, Tomoaki Ida, Tetsuro Matsunaga, Daniel R. Flicker, Benjamin Corman, Naohiro Mori, Yumiko Yamazaki, Annabelle Batten, Rebecca Li, Tomohiro Tanaka, Takamitsu Ikeda, Akito Nakagawa, Dmitriy N. Atochin, Hideshi Ihara, Benjamin A. Olenchock, Xinggui Shen, Motohiro Nishida, Kenjiro Hanaoka, Christopher G. Kevil, Ming Xian, Donald B. Bloch, Takaaki Akaike, Allyson G. Hindle, Hozumi Motohashi, Fumito Ichinose
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The brain is sensitive to oxygen deprivation. Here, the authors show in experimental animals that sensitivity to hypoxia is inversely related to the level of sulfide:quinone oxidoreductast (SQOR) and the capacity to catabolize sulfide in the brain.
Externí odkaz:
https://doaj.org/article/e9e4bccfec79480492fb63f03e33bd26
Autor:
Eizo Marutani, Fumito Ichinose
Publikováno v:
Intensive Care Medicine Experimental, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Hydrogen sulfide (H2S) has long been known as a toxic environmental hazard. Discovery of physiological roles of H2S as a neurotransmitter by Kimura and colleagues triggered an intensive research in the biological roles of H2S in the past dec
Externí odkaz:
https://doaj.org/article/df086f2d364544cf9886213a1fbb4c4f
Autor:
Mariko Ezaka, Eizo Marutani, Yusuke Miyazaki, Eiki Kanemaru, Martin K. Selig, Sophie L. Boerboom, Katrina F. Ostrom, Anat Stemmer-Rachamimov, Donald B. Bloch, Gary J. Brenner, Etsuo Ohshima, Fumito Ichinose
Publikováno v:
Antioxidants, Vol 11, Iss 11, p 2122 (2022)
Peripheral neuropathy is a dose-limiting side effect of chemotherapy with paclitaxel. Paclitaxel-induced peripheral neuropathy (PIPN) is typically characterized by a predominantly sensory neuropathy presenting with allodynia, hyperalgesia and spontan
Externí odkaz:
https://doaj.org/article/fa29d65e66d94a90817c05e453bffe5a
Autor:
Bodil Petersen, Cornelius J. Busch, Grigorij Schleifer, Dominik Schaack, Felix Lasitschka, Kenneth D. Bloch, Donald B. Bloch, Fumito Ichinose
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously showed that nitric ox
Externí odkaz:
https://doaj.org/article/e25ed4aa6e604622aeec12eafb54322b
Autor:
Steffen B. Wiegand, Lisa Traeger, Huan K. Nguyen, Kaitlyn R. Rouillard, Anna Fischbach, Francesco Zadek, Fumito Ichinose, Mark H. Schoenfisch, Ryan W. Carroll, Donald B. Bloch, Warren M. Zapol
Publikováno v:
Redox Biology, Vol 39, Iss , Pp 101826- (2021)
Rationale: Inhalation of nitric oxide (NO) exerts selective pulmonary vasodilation. Nitric oxide also has an antimicrobial effect on a broad spectrum of pathogenic viruses, bacteria and fungi. Objectives: The aim of this study was to investigate the
Externí odkaz:
https://doaj.org/article/1ed8d9ccad5644c0a131a74d3e20da81
Autor:
Bradley A. Maron, Mark T. Gladwin, Sebastien Bonnet, Vinicio De Jesus Perez, Sarah M. Perman, Paul B. Yu, Fumito Ichinose
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 14 (2020)
Externí odkaz:
https://doaj.org/article/098a9e88b53948e7b884b49656a93f67
Autor:
Yasuko Nagasaka, Martin Wepler, Robrecht Thoonen, Patrick Y. Sips, Kaitlin Allen, Jan A. Graw, Vincent Yao, Sara M. Burns, Stefan Muenster, Peter Brouckaert, Keith Miller, Ken Solt, Emmanuel S. Buys, Fumito Ichinose, Warren M. Zapol
Publikováno v:
BMC Anesthesiology, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background Volatile anesthetics increase levels of the neurotransmitter nitric oxide (NO) and the secondary messenger molecule cyclic guanosine monophosphate (cGMP) in the brain. NO activates the enzyme guanylyl cyclase (GC) to produce cGMP.
Externí odkaz:
https://doaj.org/article/3d7736b43ffc4efb93722d94e1bc47ee