Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Fumito, Ito"'
Autor:
Layla Shojaie, Jacob M. Bogdanov, Helia Alavifard, Mahmoud G. Mohamed, Aria Baktash, Myra Ali, Simeon Mahov, Sue Murray, Gary C. Kanel, Zhang-Xu Liu, Fumito Ito, Gino K. In, Akil Merchant, William Stohl, Lily Dara
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-16 (2024)
Abstract Immune checkpoints (CTLA4 & PD-1) are inhibitory pathways that block aberrant immune activity and maintain self-tolerance. Tumors co-opt these checkpoints to avoid immune destruction. Immune checkpoint inhibitors (ICIs) activate immune cells
Externí odkaz:
https://doaj.org/article/1c457dccc2cc49eebdd7ce8656ba227a
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Compelling evidence shows that the frequency of T cells in the tumor microenvironment correlates with prognosis as well as response to immunotherapy. However, considerable heterogeneity exists within tumor-infiltrating T cells, and significa
Externí odkaz:
https://doaj.org/article/c94c59d7608442afb2b75ec19481b43e
Autor:
Gino K. In, Jennifer R. Ribeiro, Jun Yin, Joanne Xiu, Matias A. Bustos, Fumito Ito, Frances Chow, Gabriel Zada, Lindsay Hwang, April K. S. Salama, Soo J. Park, Justin C. Moser, Sourat Darabi, Evidio Domingo-Musibay, Maria L. Ascierto, Kim Margolin, Jose Lutzky, Geoffrey T. Gibney, Michael B. Atkins, Benjamin Izar, Dave S. B. Hoon, Ari M. VanderWalde
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-10 (2023)
Abstract Melanoma brain metastases (MBM) are clinically challenging to treat and exhibit variable responses to immune checkpoint therapies. Prior research suggests that MBM exhibit poor tumor immune responses and are enriched in oxidative phosphoryla
Externí odkaz:
https://doaj.org/article/32efd05519e741b4bbdba359b3adab39
Autor:
Kevin Kelly, Gino K In, Jeffrey Sosman, Sunandana Chandra, Jacob Thomas, Fumito Ito, Daniel Kwon, Hugo Lara Martinez, Erin Barrett, Ashley Wysong, Alissa Marr, Joshua Mammen, Thomas Won, Anisa Sandin, Sophia Marmolejo, Andrew Zeng, Niels Kokot, Mark Swanson, Denice Tsao-Wei, Susan Groshen, Andy Sherrod, Brittney Declerck, Gene Kim, David Peng, Jenny C Hu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/a444398a18f04ebea1f52094a4e4c199
Autor:
Rajeev Sharma, Hongbin Chen, Takaaki Oba, Fumito Ito, Kristopher Attwood, Grace Dy, Eihab Abdelfatah, Lauren Polyakov, Joy Sarkar, Brahm Segal
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/a974234f31e447859b8bf29360478272
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Despite recent progress in therapeutic strategies, prognosis of metastatic triple-negative breast cancer (TNBC) remains dismal. Evidence suggests that the induction and activation of tumor-residing conventional type-1 dendritic cells (cDC1s)
Externí odkaz:
https://doaj.org/article/a47ce881037545fd9257a49e41ccbe12
Autor:
Takayoshi Yamauchi, Toshifumi Hoki, Takaaki Oba, Vaibhav Jain, Hongbin Chen, Kristopher Attwood, Sebastiano Battaglia, Saby George, Gurkamal Chatta, Igor Puzanov, Carl Morrison, Kunle Odunsi, Brahm H. Segal, Grace K. Dy, Marc S. Ernstoff, Fumito Ito
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
There is an urgent need to discover blood-based biomarkers to predict response to immune checkpoint inhibitors (ICI). Here the authors show that effective ICI therapy correlates with increased frequency of circulating CX3CR1+CD8+ T cells in preclinic
Externí odkaz:
https://doaj.org/article/5ad9763c2d134ba4b389bb215a94772a
Autor:
Takaaki Oba, Mark D. Long, Tibor Keler, Henry C. Marsh, Hans Minderman, Scott I. Abrams, Song Liu, Fumito Ito
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Strategies to increase T cell infiltration within the tumor microenvironment could improve response to immune checkpoint blockade. Here the authors show that a combinatorial regimen based on Flt3L, radiotherapy, and TLR3/CD40 stimulation promotes int
Externí odkaz:
https://doaj.org/article/624c24703da040c89811cce847e51d8c
Autor:
Song Liu, Satoko Matsueda, Takaaki Oba, Fumito Ito, Kenichi Makino, Ryutaro Kajihara, Mark D Long, Kazunori Kanehira
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/84df69c6958746a3961bce3bf5a5d676
Autor:
Xuedan He, Shiqi Zhou, Breandan Quinn, Wei‐Chiao Huang, Dushyant Jahagirdar, Michael Vega, Joaquin Ortega, Mark D. Long, Fumito Ito, Scott I. Abrams, Jonathan F. Lovell
Publikováno v:
Advanced Science, Vol 8, Iss 24, Pp n/a-n/a (2021)
Abstract Short peptides reflecting major histocompatibility complex (MHC) class I (MHC‐I) epitopes frequently lack sufficient immunogenicity to induce robust antigen (Ag)‐specific CD8+ T cell responses. In the current work, it is demonstrated tha
Externí odkaz:
https://doaj.org/article/e7289c7a9a7a49198481cde87f2c3b75