Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Fumitaka Takeshita"'
Autor:
Marta Prieto‐Vila, Wataru Usuba, Yusuke Yoshioka, Fumitaka Takeshita, Miki Yoshiike, Hideo Sasaki, Yusuke Yamamoto, Eiji Kikuchi, Takahiro Ochiya
Publikováno v:
Journal of Extracellular Biology, Vol 1, Iss 8, Pp n/a-n/a (2022)
Abstract Recurrence is one of the major issues in bladder cancer (BCa). Novel technologies, such as the detection of microRNAs carried by extracellular vesicles (EVs) in urine, have been proposed as biomarkers for detecting recurrence in BCa. Althoug
Externí odkaz:
https://doaj.org/article/224dc29930d8463986a0ee6d8a33a33b
Autor:
Anna Sanchez Calle, Tomofumi Yamamoto, Yumi Kawamura, Ai Hironaka‐Mitsuhashi, Makiko Ono, Hitoshi Tsuda, Akihiko Shimomura, Kenji Tamura, Fumitaka Takeshita, Takahiro Ochiya, Yusuke Yamamoto
Publikováno v:
Molecular Oncology, Vol 14, Iss 9, Pp 2271-2287 (2020)
The tenacity of late recurrence of estrogen receptor (ER)‐positive breast cancer remains a major clinical issue to overcome. The administration of endocrine therapies within the first 5 years substantially minimizes the risk of relapse; however, so
Externí odkaz:
https://doaj.org/article/256cf90d3d974c9fac6949cedf599db4
Autor:
Yusuke Yamamoto, Shunsuke Kondo, Juntaro Matsuzaki, Minoru Esaki, Takuji Okusaka, Kazuaki Shimada, Yoshiki Murakami, Masaru Enomoto, Akihiro Tamori, Ken Kato, Yoshiaki Aoki, Satoko Takizawa, Hiromi Sakamoto, Shumpei Niida, Fumitaka Takeshita, Takahiro Ochiya
Publikováno v:
Hepatology Communications, Vol 4, Iss 2, Pp 284-297 (2020)
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer deaths worldwide. The high mortality rate in HCC is largely due to the difficulty of early detection. In this study, to improve patient outcomes, serum samples from 345 patients wit
Externí odkaz:
https://doaj.org/article/151024bfb4a24192a10becd1aeb3a9c3
Autor:
Yuko Fujiwara, Motonobu Saito, Ana I. Robles, Momoyo Nishida, Fumitaka Takeshita, Masatoshi Watanabe, Takahiro Ochiya, Jun Yokota, Takashi Kohno, Curtis C. Harris, Naoto Tsuchiya
Publikováno v:
EBioMedicine, Vol 33, Iss , Pp 33-48 (2018)
Background: Activation of intrinsic p53 tumor-suppressor (TS) pathways is an important principle underlying cancer chemotherapy. It is necessary to elucidate the precise regulatory mechanisms of these networks to create new treatment strategies. Meth
Externí odkaz:
https://doaj.org/article/111276e6729e4bceaecc992119f1cba7
Autor:
Akira Yokoi, Yusuke Yoshioka, Yusuke Yamamoto, Mitsuya Ishikawa, Shun-ichi Ikeda, Tomoyasu Kato, Tohru Kiyono, Fumitaka Takeshita, Hiroaki Kajiyama, Fumitaka Kikkawa, Takahiro Ochiya
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Ovarian cancer is particularly deadly because it is difficult to detect at the pre-metastatic stage; extracellular vesicles (EVs) on the other hand are involved in the pre-metastatic niche preparation. Here the authors show that EVs mediate ovarian c
Externí odkaz:
https://doaj.org/article/01072f72c9bf4248ab7c3c3c444661b4
Autor:
Chihiro Otsubo, Ryo Otomo, Makoto Miyazaki, Yuko Matsushima-Hibiya, Takashi Kohno, Reika Iwakawa, Fumitaka Takeshita, Hirokazu Okayama, Hitoshi Ichikawa, Hideyuki Saya, Tohru Kiyono, Takahiro Ochiya, Fumio Tashiro, Hitoshi Nakagama, Jun Yokota, Masato Enari
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 527-538 (2014)
Summary: In lung cancer progression, p53 mutations are more often observed in invasive tumors than in noninvasive tumors, suggesting that p53 is involved in tumor invasion and metastasis. To understand the nature of p53 function as a tumor suppressor
Externí odkaz:
https://doaj.org/article/e73b97deeab04def8cdc0bfcc1c5e983
Publikováno v:
Pharmaceuticals, Vol 6, Iss 2, Pp 223-250 (2013)
RNA interference (RNAi) is rapidly becoming an important method for analyzing gene functions in many eukaryotes and holds promise for the development of therapeutic gene silencing. The induction of RNAi relies on small silencing RNAs, which affect sp
Externí odkaz:
https://doaj.org/article/8da6441a8e46447eba8ea2ff8b3f4c63
miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma
Autor:
Daisuke Kubota, Nobuyoshi Kosaka, Tomohiro Fujiwara, Akihiko Yoshida, Yasuhito Arai, Zhiwei Qiao, Fumitaka Takeshita, Takahiro Ochiya, Akira Kawai, Tadashi Kondo
Publikováno v:
Sarcoma, Vol 2016 (2016)
Osteosarcoma is the most common primary malignancy in bone. Patients who respond poorly to induction chemotherapy are at higher risk of adverse prognosis. The molecular basis for such poor prognosis remains unclear. We investigated miRNA expression i
Externí odkaz:
https://doaj.org/article/c098440a07dc4ab9bff01ea9ebe0a877
Autor:
Masayuki Komatsu, Hitoshi Ichikawa, Fumiko Chiwaki, Hiromi Sakamoto, Rie Komatsuzaki, Makoto Asaumi, Kazuhisa Tsunoyama, Takeo Fukagawa, Hiromichi Matsushita, Narikazu Boku, Keisuke Matsusaki, Fumitaka Takeshita, Teruhiko Yoshida, Hiroki Sasaki
Publikováno v:
Oncogene. 41:4779-4794
Genetic alteration of Rho GTPase-activating proteins (ARHGAP) and GTPase RhoA is a hallmark of diffuse-type gastric cancer and elucidating its biological significance is critical to comprehensively understanding this malignancy. Here, we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602bc8e2967343ce0492974928276662
https://doi.org/10.1038/s41388-022-02469-6
https://doi.org/10.1038/s41388-022-02469-6
Autor:
Tesshi Yamada, Setsuo Hirohashi, Takahiro Ochiya, Tomoo Kosuge, Kazufumi Honda, Takafumi Jigami, Hidenori Ojima, Fumitaka Takeshita, Yae Kanai, Miki Shitashige, Reiko Satow
Purpose: The outcome of patients with advanced hepatocellular carcinoma (HCC) has remained unsatisfactory. Patients with HCC suffer from chronic hepatitis or liver cirrhosis, and their reserve liver function is often limited.Experimental Design: To d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ee7caf1f0c0baf2618540327068e3a
https://doi.org/10.1158/1078-0432.c.6517921.v1
https://doi.org/10.1158/1078-0432.c.6517921.v1
