Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Fumitaka Kugimiya"'
Autor:
Fumitaka Kugimiya, Shigeyuki Muraki, Daisuke Nagakura, Hidemasa Umekoji, Hiromi Oda, Keisuke Takahashi
Publikováno v:
Spine Surgery and Related Research, Vol 1, Iss 3, Pp 135-139 (2017)
Introduction: Although initial treatments for pyogenic spondylitis include conservative approaches such as rest and antibiotics, some cases are refractory to conservative therapy. The objective of this study was to clarify the predictors for achievem
Externí odkaz:
https://doaj.org/article/e48e16aea4e74ebfa4c80819fc4cfb08
Autor:
Makoto Hirata, Fumitaka Kugimiya, Atsushi Fukai, Shinsuke Ohba, Naohiro Kawamura, Toru Ogasawara, Yosuke Kawasaki, Taku Saito, Fumiko Yano, Toshiyuki Ikeda, Kozo Nakamura, Ung-Il Chung, Hiroshi Kawaguchi
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4543 (2009)
BACKGROUND: Although transition from proliferation to hypertrophic differentiation of chondrocytes is a crucial step for endochondral ossification in physiological skeletal growth and pathological disorders like osteoarthritis, the underlying mechani
Externí odkaz:
https://doaj.org/article/a4e79d953f21460d96433ec3034f22f2
Autor:
Naohiro Kawamura, Fumitaka Kugimiya, Yasushi Oshima, Shinsuke Ohba, Toshiyuki Ikeda, Taku Saito, Yusuke Shinoda, Yosuke Kawasaki, Naoshi Ogata, Kazuto Hoshi, Toru Akiyama, William S Chen, Nissim Hay, Kazuyuki Tobe, Takashi Kadowaki, Yoshiaki Azuma, Sakae Tanaka, Kozo Nakamura, Ung-il Chung, Hiroshi Kawaguchi
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e1058 (2007)
Bone mass and turnover are maintained by the coordinated balance between bone formation by osteoblasts and bone resorption by osteoclasts, under regulation of many systemic and local factors. Phosphoinositide-dependent serine-threonine protein kinase
Externí odkaz:
https://doaj.org/article/b087c7a6b12e40778f05568f6ac44d6b
Autor:
Fumitaka Kugimiya, Hiroshi Kawaguchi, Shinsuke Ohba, Naohiro Kawamura, Makoto Hirata, Hirotaka Chikuda, Yoshiaki Azuma, James R Woodgett, Kozo Nakamura, Ung-il Chung
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e837 (2007)
Despite accumulated knowledge of various signalings regulating bone formation, the molecular network has not been clarified sufficiently to lead to clinical application. Here we show that heterozygous glycogen synthase kinase-3beta (GSK-3beta)-defici
Externí odkaz:
https://doaj.org/article/cb8148cc13c44aa29e89b5023e0b2070
Autor:
Akihiko Mabuchi, Atsushi Fukai, Nao Nishida, Noriko Yoshimura, Fumiko Yano, Hiroshi Kawaguchi, Makoto Hirata, Taku Saito, Kozo Nakamura, Ung-il Chung, Bishwa Raj Sapkota, Toshiyuki Ikeda, Takumi Nakagawa, Katsushi Tokunaga, Fumitaka Kugimiya, Toru Akune
Publikováno v:
Human Molecular Genetics. 21:1111-1123
To elucidate the molecular mechanism underlying the endochondral ossification process during the skeletal growth and osteoarthritis (OA) development, we examined the signal network around CCAAT/enhancer-binding protein-β (C/EBPβ, encoded by CEBPB),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b02f384d88d274205a045874c6e5382
https://doi.org/10.1093/hmg/ddr540
https://doi.org/10.1093/hmg/ddr540
Autor:
Kunihiko Suzuki, Shuhei Murase, Hiroshi Maruyama, Kenichi Kawano, Tanefumi Nakagawa, Takashi Shirato, Fumitaka Kugimiya
Publikováno v:
Orthopedics & Traumatology. 60:548-551
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d45e16ac37fc564afd38bba181c8e741
https://doi.org/10.5035/nishiseisai.60.548
https://doi.org/10.5035/nishiseisai.60.548
Autor:
Akiro Higashikawa, Kazuto Hoshi, Kensuke Tsushima, Kozo Nakamura, Yosuke Kawasaki, Takashi Yamada, Ryozo Nagai, Ichiro Manabe, Fumitaka Kugimiya, Norifumi Takeda, Naoshi Ogata, Hiroshi Kawaguchi, Yusuke Shinoda, Ung-il Chung, Naohiro Kawamura, Toshiyuki Ikeda, Takayuki Shindo
Publikováno v:
Journal of Biological Chemistry. 283:24682-24689
Although degradation of cartilage matrix has been suggested to be a rate-limiting step for endochondral ossification during skeletal development, little is known about the transcriptional regulation. This study investigated the involvement of KLF5 (K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911657cd3e5440899d4ed591f9c9272d
https://doi.org/10.1074/jbc.m709857200
https://doi.org/10.1074/jbc.m709857200
Autor:
Toru Moro, Yusuke Komiyama, Kazuyo Igawa, Hiroshi Kawaguchi, Shinsuke Ohba, Keiji Itaka, Kozo Nakamura, Ung-il Chung, Keiji Nakajima, Fumitaka Kugimiya, Tsuyoshi Takato
Publikováno v:
Biochemical and Biophysical Research Communications. 357:854-860
To effectively treat serious bone defects using bone regenerative medicine, there is a need for the development of a small chemical compound that potently induces bone formation. We now report a novel osteogenic helioxanthin-derivative, TH. TH induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e52c428f7b33815b5ae6ce041aee31
https://doi.org/10.1016/j.bbrc.2007.03.173
https://doi.org/10.1016/j.bbrc.2007.03.173
Autor:
Ung-il Chung, Hiroshi Kawaguchi, Toshiyuki Ikeda, Alexander C. Lichtler, Shinsuke Ohba, Tsuyoshi Takato, Kozo Nakamura, Fumitaka Kugimiya, Fumiko Yano
Publikováno v:
The FASEB Journal. 21:1777-1787
To identify potent bioactive factors for in vivo tissue regeneration by comprehensive screening remains a challenge for regenerative medicine. Here we report the development of an ES cell-based monitoring system for osteogenic differentiation, the id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabefe20ce6ea2509bfdf2d2d8b57750
https://doi.org/10.1096/fj.06-7571com
https://doi.org/10.1096/fj.06-7571com
Autor:
Naoshi Ogata, Satoru Kamekura, Shinsuke Ohba, Yoshifumi Harada, Ung-il Chung, Hiroshi Kawaguchi, Takenobu Katagiri, Kozo Nakamura, Hirotaka Chikuda, Yoshiaki Azuma, Fumitaka Kugimiya, Fumiko Yano
Publikováno v:
Journal of Biological Chemistry. 280:35704-35712
Although accumulated evidence has shown the bone anabolic effects of bone morphogenetic proteins (BMPs) that were exogenously applied in vitro and in vivo, the roles of endogenous BMPs during bone formation remain to be clarified. This study initiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1365be94b90b5419d49753d88ee432
https://doi.org/10.1074/jbc.m505166200
https://doi.org/10.1074/jbc.m505166200