Zobrazeno 1 - 10 of 126 pro vyhledávání: '"Fumitaka, Kudo"'
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Akademický článek
Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host
Autor: Keita Amagai, Haruo Ikeda, Junko Hashimoto, Ikuko Kozone, Miho Izumikawa, Fumitaka Kudo, Tadashi Eguchi, Takemichi Nakamura, Hiroyuki Osada, Shunji Takahashi, Kazuo Shin-ya
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Telomestatin, a strong telomerase inhibitor with G-quadruplex stabilizing activity, is a potential therapeutic agent for treating cancers. Difficulties in isolating telomestatin from microbial cultures and in chemical synthesis are bottlenec
Externí odkaz: https://doaj.org/article/bc74afa0add84c29833f93ffbe2a2b0d
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4
Akademický článek
Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR.
Autor: Xiaoli Zhang, Wei Chen, Qiong Gao, Junsheng Yang, Xueni Yan, Han Zhao, Lin Su, Meimei Yang, Chenlang Gao, Yao Yao, Ken Inoki, Dan Li, Rong Shao, Shiyi Wang, Nirakar Sahoo, Fumitaka Kudo, Tadashi Eguchi, Benfang Ruan, Haoxing Xu
Publikováno v: PLoS Biology, Vol 17, Iss 5, p e3000252 (2019)
Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a
Externí odkaz: https://doaj.org/article/7572bdcdbb8b4629856919a744d68590
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6
Acyltransferase Domain Exchanges between Two Independent Type I Polyketide Synthases in the Same Producer Strain of Macrolide Antibiotics
Autor: Fumitaka Kudo, Kosuke Kishikawa, Kazuma Tsuboi, Takafusa Kido, Takeo Usui, Junko Hashimoto, Kazuo Shin‐ya, Akimasa Miyanaga, Tadashi Eguchi
Publikováno v: ChemBioChem. 24(No. 6)
Streptomyces graminofaciens A-8890 produces two macrolide antibiotics, FD-891 and virustomycin A, both of which show significant biological activities. In this study, we identified the virustomycin A biosynthetic gene cluster, which encodes type I po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31292c41a2b12390d70f355bf870e8b
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100887107
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9
Structural Basis of Transient Interactions of Acyltransferase VinK with the Loading Acyl Carrier Protein of the Vicenistatin Modular Polyketide Synthase
Autor: Akimasa Miyanaga, Koichi Kawada, Taichi Chisuga, Fumitaka Kudo, Tadashi Eguchi
Publikováno v: Biochemistry. 62(1)
Acyltransferase (AT) recognizes its cognate acyl carrier protein (ACP) for functional transfer of an acyl unit in polyketide biosynthesis. However, structural characterization of AT-ACP complexes is limited because of the weak and transient interacti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b33fdce13b7f9ff9cc40db2853db42f
https://pubmed.ncbi.nlm.nih.gov/36512613
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