Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Fumio Sakane"'
Publikováno v:
FEBS Open Bio, Vol 13, Iss 7, Pp 1333-1345 (2023)
We previously reported that diacylglycerol (DG) kinase (DGK) δ interacts with DG‐generating sphingomyelin synthase (SMS)‐related protein (SMSr), but not SMS1 or SMS2, via their sterile α motif domains (SAMDs). However, it remains unclear whethe
Externí odkaz:
https://doaj.org/article/13960357595a4994a3761e0c22e04cce
Publikováno v:
FEBS Open Bio, Vol 12, Iss 10, Pp 1788-1796 (2022)
Effective amelioration of type II diabetes requires therapies that increase both glucose uptake activity per cell and skeletal muscle mass. Myristic acid (14:0) increases diacylglycerol kinase (DGK) δ protein levels and enhances glucose uptake in my
Externí odkaz:
https://doaj.org/article/e6f3b3f04757499c8a826dd27186b038
Publikováno v:
Biochemistry and Biophysics Reports, Vol 26, Iss , Pp 101006- (2021)
Diacylglycerol kinase (DGK) η translocates from the cytoplasm to punctate vehicles via osmotic shock. Apoptosis signal-regulating kinase (ASK) 3 (MAP kinase kinase kinase (MAPKKK) 15) is also reported to respond to osmotic shock. Therefore, in the p
Externí odkaz:
https://doaj.org/article/874ec32b0fc44ed5b7fe1b3890d26331
Publikováno v:
ACS Omega, Vol 4, Iss 3, Pp 5540-5546 (2019)
Externí odkaz:
https://doaj.org/article/15c7d7fa225142038bb2360f768ac1c8
Publikováno v:
Biochemistry and Biophysics Reports, Vol 22, Iss , Pp - (2020)
Phosphatidic acid (PA) is the simplest phospholipid and is involved in the regulation of various cellular events. Recently, we developed a new PA sensor, the N-terminal region of α-synuclein (α-Syn-N). However, whether α-Syn-N can sense physiologi
Externí odkaz:
https://doaj.org/article/0ec1b1ac2429461eabeb32b2e0e5ec94
Autor:
Suguru Komenoi, Yuji Suzuki, Maho Asami, Chiaki Murakami, Fumi Hoshino, Sohei Chiba, Daisuke Takahashi, Sayaka Kado, Fumio Sakane
Publikováno v:
Biochemistry and Biophysics Reports, Vol 19, Iss , Pp - (2019)
We have revealed that diacylglycerol kinase η (DGKη)-knockout (KO) mice display bipolar disorder (BPD) remedy-sensitive mania-like behaviors. However, the molecular mechanisms causing the mania-like abnormal behaviors remain unclear. In the present
Externí odkaz:
https://doaj.org/article/7e399a45b8fe4a0a98a1a25cf0605444
Autor:
Ke Liu, Naoko Kunii, Megumi Sakuma, Atsumi Yamaki, Satoru Mizuno, Mayu Sato, Hiromichi Sakai, Sayaka Kado, Kazuo Kumagai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Yasuhito Shirai, Fumio Sakane
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 3, Pp 368-379 (2016)
Diacylglycerol kinase (DGK) consists of 10 isozymes. The α-isozyme enhances the proliferation of cancer cells. However, DGKα facilitates the nonresponsive state of immunity known as T-cell anergy; therefore, DGKα enhances malignant traits and supp
Externí odkaz:
https://doaj.org/article/dc143d608bfc4fb194ef0301e1ccb9c8
Autor:
Daisuke Takahashi, Fumio Sakane
Publikováno v:
PeerJ, Vol 6, p e5449 (2018)
Diacylglycerol kinases (DGKs) are lipid kinases that modulate the levels of lipid second messengers, diacylglycerol and phosphatidic acid. Recently, increasing attention has been paid to its α isozyme (DGKα) as a potential target for cancer immunot
Externí odkaz:
https://doaj.org/article/4cd8c0380e154f7c80aed36a986a3c6f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 5 (2017)
Externí odkaz:
https://doaj.org/article/aea09ca24c364fafb737f803049c8b59
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 387-392 (2014)
Diacylglycerol kinase (DGK) α, which is activated by Ca2+, contains a recoverin homology (RVH) domain, tandem repeats of two Ca2+-binding EF-hand motifs, two cysteine-rich C1 domains and the catalytic domain. We previously found that a DGKα mutant
Externí odkaz:
https://doaj.org/article/cc165640042544a88fa5f6f1c1aef1cc