Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Fumio Hanaoka"'
Autor:
Yusuke Matsuno, Yuko Atsumi, Atsuhiro Shimizu, Kotoe Katayama, Haruka Fujimori, Mai Hyodo, Yusuke Minakawa, Yoshimichi Nakatsu, Syuzo Kaneko, Ryuji Hamamoto, Teppei Shimamura, Satoru Miyano, Teruhisa Tsuzuki, Fumio Hanaoka, Ken-ichi Yoshioka
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. Here authors reveal a mechanism by which replication stress induces MSI and associated induction of mutations in vitro.
Externí odkaz:
https://doaj.org/article/3a59f10420754664b934a81589710d65
Autor:
Shu-ichiro Kashiwaba, Rie Kanao, Yuji Masuda, Rika Kusumoto-Matsuo, Fumio Hanaoka, Chikahide Masutani
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2072-2080 (2015)
Mono-ubiquitinated PCNA activates error-prone DNA polymerases; therefore, strict regulation of PCNA mono-ubiquitination is crucial in avoiding undesired mutagenesis. In this study, we used an in vitro assay system to identify USP7 as a deubiquitinati
Externí odkaz:
https://doaj.org/article/0db0e25a03e9469fa0218542d8e84e7d
Autor:
Takeshi Yasuda, Wataru Kagawa, Tomoo Ogi, Takamitsu A Kato, Takehiro Suzuki, Naoshi Dohmae, Kazuya Takizawa, Yuka Nakazawa, Matthew D Genet, Mika Saotome, Michio Hama, Teruaki Konishi, Nakako Izumi Nakajima, Masaharu Hazawa, Masanori Tomita, Manabu Koike, Katsuko Noshiro, Kenichi Tomiyama, Chizuka Obara, Takaya Gotoh, Ayako Ui, Akira Fujimori, Fumiaki Nakayama, Fumio Hanaoka, Kaoru Sugasawa, Ryuichi Okayasu, Penny A Jeggo, Katsushi Tajima
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007277 (2018)
The p300 and CBP histone acetyltransferases are recruited to DNA double-strand break (DSB) sites where they induce histone acetylation, thereby influencing the chromatin structure and DNA repair process. Whether p300/CBP at DSB sites also acetylate n
Externí odkaz:
https://doaj.org/article/e1679cb73def4710aa1a8cba50af9b31
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0130000 (2015)
Translesion DNA synthesis provides an alternative DNA replication mechanism when template DNA is damaged. In fission yeast, Eso1 (polη), Kpa1/DinB (polκ), Rev1, and Polζ (a complex of Rev3 and Rev7) have been identified as translesion synthesis po
Externí odkaz:
https://doaj.org/article/f8ad62845f0e42d4b90e1f80c732d9aa
Autor:
Rie Kanao, Yuji Masuda, Saori Deguchi, Mayumi Yumoto-Sugimoto, Fumio Hanaoka, Chikahide Masutani
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118775 (2015)
DNA damage tolerance (DDT) pathways, including translesion synthesis (TLS) and additional unknown mechanisms, enable recovery from replication arrest at DNA lesions. DDT pathways are regulated by post-translational modifications of proliferating cell
Externí odkaz:
https://doaj.org/article/ec32f8d0c1e640c7a634e6d306e9f80b
Autor:
Kouji Hirota, Eiichiro Sonoda, Takuo Kawamoto, Akira Motegi, Chikahide Masutani, Fumio Hanaoka, Dávid Szüts, Shigenori Iwai, Julian E Sale, Alan Lehmann, Shunichi Takeda
Publikováno v:
PLoS Genetics, Vol 6, Iss 10 (2010)
Replicative DNA polymerases are frequently stalled by DNA lesions. The resulting replication blockage is released by homologous recombination (HR) and translesion DNA synthesis (TLS). TLS employs specialized TLS polymerases to bypass DNA lesions. We
Externí odkaz:
https://doaj.org/article/8da1f6191d1b461e8ef6c6a2e071181b
Autor:
Sayo Kashiwagi, Isao Kuraoka, Yoshie Fujiwara, Kenichi Hitomi, Quen J. Cheng, Jill O. Fuss, David S. Shin, Chikahide Masutani, John A. Tainer, Fumio Hanaoka, Shigenori Iwai
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Human DNA polymerase η (HsPolη) plays an important role in translesion synthesis (TLS), which allows for replication past DNA damage such as UV-induced cis-syn cyclobutane pyrimidine dimers (CPDs). Here, we characterized ApPolη from the thermophil
Externí odkaz:
https://doaj.org/article/b1aa0d079d1b4a6eb756cdd3ce8515eb
Autor:
Yuichiro Shimizu, Yasuhiro Uchimura, Naoshi Dohmae, Hisato Saitoh, Fumio Hanaoka, Kaoru Sugasawa
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
We showed that XPC complex, which is a DNA damage detector for nucleotide excision repair, stimulates activity of thymine DNA glycosylase (TDG) that initiates base excision repair. XPC appeared to facilitate the enzymatic turnover of TDG by promoting
Externí odkaz:
https://doaj.org/article/dc4fb6dfe1124927a3c374d2a336ce5e
Autor:
Jinseok Kim, Chia-Lung Li, Xuemin Chen, Yanxiang Cui, Filip M. Golebiowski, Huaibin Wang, Fumio Hanaoka, Kaoru Sugasawa, Wei Yang
Publikováno v:
Nature. 617(7959):170-175
Nucleotide excision repair removes DNA lesions caused by ultraviolet light, cisplatin-like compounds and bulky adducts. After initial recognition by XPC in global genome repair or a stalled RNA polymerase in transcription-coupled repair, damaged DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355d0f764ea547cd84eb1373df500914
https://hdl.handle.net/20.500.14094/0100482020
https://hdl.handle.net/20.500.14094/0100482020
Autor:
Naoko Imamoto, Yurika Kobayashi, Kei Hirabayashi, Fumio Hanaoka, Hidetaka Torigoe, Sae Miyazawa, Kenta Shoji, Masakazu Kobayashi, Takeshi Mizuno
Publikováno v:
Genes to Cells. 26:360-380
Mouse telomerase and the DNA polymerase alpha-primase complex elongate the leading and lagging strands of telomeres, respectively. To elucidate the molecular mechanism of lagging strand synthesis, we investigated the interaction between DNA polymeras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278dbda3db7bda0a32ce5b58b39fa0e6
https://doi.org/10.1111/gtc.12845
https://doi.org/10.1111/gtc.12845