Zobrazeno 1 - 10
of 258
pro vyhledávání: '"Fumio, Nakamura"'
Autor:
Masayuki Nakano, Motokazu Koga, Tatsuo Hashimoto, Natsuki Matsushita, Daiki Masukawa, Yusuke Mizuno, Hiraku Uchimura, Ryo Niikura, Tomoyuki Miyazaki, Fumio Nakamura, Suo Zou, Takahiro Shimizu, Motoaki Saito, Kouichi Tamura, Takahisa Goto, Yoshio Goshima
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 2, Pp 214-220 (2022)
Pulmonary hypertension (PH) is a severe and progressive disease that causes elevated right ventricular systolic pressure, right ventricular hypertrophy and ultimately right heart failure. However, the underlying pathophysiologic mechanisms are poorly
Externí odkaz:
https://doaj.org/article/0731879c0abe4c7cb92a39d3bebe47cb
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract 3D cultured cell aggregates, including spheroids, reflect the gene expression patterns of living tissues/organs. Mass preparation of spheroids enables high-throughput drug screening (HTS). However, conventional optical imaging of spheroids m
Externí odkaz:
https://doaj.org/article/29e8ab50c9454904b3b2c868707067d5
Autor:
Ethiraj Ravindran, Nobuto Arashiki, Lena-Luise Becker, Kohtaro Takizawa, Jonathan Lévy, Thomas Rambaud, Konstantin L Makridis, Yoshio Goshima, Na Li, Maaike Vreeburg, Bénédicte Demeer, Achim Dickmanns, Alexander PA Stegmann, Hao Hu, Fumio Nakamura, Angela M Kaindl
Publikováno v:
eLife, Vol 11 (2022)
Collapsin response mediator proteins (CRMPs) are key for brain development and function. Here, we link CRMP1 to a neurodevelopmental disorder. We report heterozygous de novo variants in the CRMP1 gene in three unrelated individuals with muscular hypo
Externí odkaz:
https://doaj.org/article/c98656144c6a4ee89eb96a7359dd7037
Autor:
Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima, Yoshio Goshima, Hideyuki Takeuchi, Hiroshi Doi, Fumio Nakamura, Fumiaki Tanaka
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
In amyotrophic lateral sclerosis (ALS), neurodegeneration is characterized by distal axonopathy that begins at the distal axons, including the neuromuscular junctions, and progresses proximally in a “dying back” manner prior to the degeneration o
Externí odkaz:
https://doaj.org/article/9485f55f46a343b097fec5aaa355cf66
Autor:
Ayako Nakamura-Ishizu, Fumio Nakamura
Publikováno v:
Tokyo Women's Medical University Journal, Vol 5, Iss 0, Pp 29-37 (2021)
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has a wide range of clinical manifestations, including acute respiratory distress syndrome, severe inflammation, abnormal blood coagulation,
Externí odkaz:
https://doaj.org/article/eda000c2f1364437bfde82b1de867697
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Collapsin response mediator proteins (CRMPs), which consist of five homologous cytosolic proteins, are one of the major phosphoproteins in the developing nervous system. The prominent feature of the CRMP family proteins is a new class of microtubule-
Externí odkaz:
https://doaj.org/article/7a38b1c8ff554bfa9b4351c39cc4d4e4
Autor:
Keiichi Yazawa, Fumio Nakamura, Daiki Masukawa, Sho Sato, Yukihiko Hiroshima, Yasuhiro Yabushita, Ryutaro Mori, Ryusei Matsuyama, Ikuma Kato, Hideki Taniguchi, Yoshio Goshima, Itaru Endo
Publikováno v:
Translational Oncology, Vol 13, Iss 3, Pp - (2020)
Pancreatic intraepithelial neoplasia (PanIN), the most common premalignant lesion of the pancreas, is a histologically well-defined precursor to invasive pancreatic ductal adenocarcinoma (PDAC). However, the molecular mechanisms underlying the progre
Externí odkaz:
https://doaj.org/article/0e1ffe5d2cd1447d8abdf173a9c71bca
Autor:
Aderemi Caleb Aladeokin, Tomoko Akiyama, Ayuko Kimura, Yayoi Kimura, Aoi Takahashi-Jitsuki, Haruko Nakamura, Hiroko Makihara, Daiki Masukawa, Jun Nakabayashi, Hisashi Hirano, Fumio Nakamura, Takashi Saito, Takaomi Saido, Yoshio Goshima
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Alzheimer’s disease (AD) is an incurable neurodegenerative disease characterized by memory loss and neurotoxic amyloid beta (Aβ) plaques accumulation. Numerous pharmacological interventions targeting Aβ plaques accumulation have failed to allevia
Externí odkaz:
https://doaj.org/article/3959496a745b4df9a2d3b2a7a1cd1a19
Autor:
Atsuko Deguchi, Miho Watanabe-Takahashi, Taishi Mishima, Tsutomu Omori, Umeharu Ohto, Nobuto Arashiki, Fumio Nakamura, Kiyotaka Nishikawa, Yoshiro Maru
Publikováno v:
Cancer Gene Therapy.
The tumor-elicited inflammation is closely related to tumor microenvironment during tumor progression. S100A8, an endogenous ligand of Toll-like receptor 4 (TLR4), is known as a key molecule in the tumor microenvironment and premetastatic niche forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9187d65934590ca27f1a9ed9d7ea50f8
https://doi.org/10.1038/s41417-023-00604-3
https://doi.org/10.1038/s41417-023-00604-3
Publikováno v:
Journal of Cardiothoracic and Vascular Anesthesia. 36:855-861
Objectives Blood-processing techniques and preservation conditions cause storage lesions, possibly leading to adverse outcomes after transfusion. The authors investigated the metabolic changes and deformability of red blood cells (RBCs) during storag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14535e27a1e4a1a56f75427f47d04efa
https://doi.org/10.1053/j.jvca.2021.06.016
https://doi.org/10.1053/j.jvca.2021.06.016