Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Fuminori Tokunaga"'
Autor:
Kouki Hoshino, Seshiru Nakazawa, Takehiko Yokobori, Kei Hagiwara, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Kenichiro Araki, Norifumi Harimoto, Fuminori Tokunaga, Ken Shirabe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract RNF31 is a multifunctional RING finger protein implicated in various inflammatory diseases and cancers. It functions as a core component of the linear ubiquitin chain assembly complex (LUBAC), which activates the nuclear factor kappaB (NF-κ
Externí odkaz:
https://doaj.org/article/9025baf96e8442feb4c6e0ffaa86bfae
Autor:
Rie Saito, Yui Tada, Daisuke Oikawa, Yusuke Sato, Makiko Seto, Akira Satoh, Kodai Kume, Nozomi Ueki, Masahiro Nakashima, Shintaro Hayashi, Yasuko Toyoshima, Fuminori Tokunaga, Hideshi Kawakami, Akiyoshi Kakita
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-9 (2022)
Abstract Spinocerebellar ataxia (SCA) type 17-digenic TBP/STUB1 disease (SCA17-DI) has been recently segregated from SCA17, caused by digenic inheritance of two gene mutations – intermediate polyglutamine-encoding CAG/CAA repeat expansions (polyQ)
Externí odkaz:
https://doaj.org/article/0cb6c438ce29432bb7b334fab44f0fec
Autor:
Daisuke Oikawa, Min Gi, Hidetaka Kosako, Kouhei Shimizu, Hirotaka Takahashi, Masayuki Shiota, Shuhei Hosomi, Keidai Komakura, Hideki Wanibuchi, Daisuke Tsuruta, Tatsuya Sawasaki, Fuminori Tokunaga
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-13 (2022)
Abstract Deubiquitinating enzymes (DUBs) regulate numerous cellular functions by removing ubiquitin modifications. We examined the effects of 88 human DUBs on linear ubiquitin chain assembly complex (LUBAC)-induced NF-κB activation, and identified O
Externí odkaz:
https://doaj.org/article/fe70c29a724549b484edddcd9d122578
Autor:
Dinh Viet Hoang, Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Kenjiro Kimura, Daisuke Oikawa, Yoshihiro Ikura, Ninh Quoc Dat, Truong Huu Hoang, Misako Sato-Matsubara, Minh Phuong Dong, Ngo Vinh Hanh, Sawako Uchida-Kobayashi, Fuminori Tokunaga, Shoji Kubo, Naoko Ohtani, Katsutoshi Yoshizato, Norifumi Kawada
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-13 (2022)
Abstract Pancreatic cancer is a highly challenging malignancy with extremely poor prognosis. Cytoglobin (CYGB), a hemeprotein involved in liver fibrosis and cancer development, is expressed in pericytes of all organs. Here, we examined the role of CY
Externí odkaz:
https://doaj.org/article/cd03332a8f1a4b8a91e1f4acb0f2336f
Autor:
Masaya Fukushi, Ryosuke Ohsawa, Yasushi Okinaka, Daisuke Oikawa, Tohru Kiyono, Masaya Moriwaki, Takashi Irie, Kosuke Oda, Yasuhiro Kamei, Fuminori Tokunaga, Yusuke Sotomaru, Hirofumi Maruyama, Hideshi Kawakami, Takemasa Sakaguchi
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0287545 (2023)
BackgroundOptineurin (OPTN) is associated with several human diseases, including amyotrophic lateral sclerosis (ALS), and is involved in various cellular processes, including autophagy. Optineurin regulates the expression of interferon beta (IFNβ),
Externí odkaz:
https://doaj.org/article/f5b455a33f0c4fe19378e93d6477d841
Autor:
Yusuke Sato, Seigo Terawaki, Daisuke Oikawa, Kouhei Shimizu, Yoshinori Okina, Hidefumi Ito, Fuminori Tokunaga
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
In neurodegenerative diseases such as Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS), the progressive accumulation of ubiquitin-positive cytoplasmic inclusions leads to proteinopathy and neurodegeneration. Along with the seven typ
Externí odkaz:
https://doaj.org/article/d8f01cf8618145d186a9dad5b134b967
Autor:
Yuko Kuriyama, Akira Shimizu, Saki Kanai, Daisuke Oikawa, Sei-ichiro Motegi, Fuminori Tokunaga, Osamu Ishikawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Type I interferon (IFN) plays a crucial role in innate and adaptive immunity, and aberrant IFN responses are involved in systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and dermatomyositis (DM). Type I IFNs can be in
Externí odkaz:
https://doaj.org/article/633fb43b43864195abf8380da0ad4197
Autor:
Vu Ngoc Hieu, Le Thi Thanh Thuy, Hoang Hai, Ninh Quoc Dat, Dinh Viet Hoang, Ngo Vinh Hanh, Dong Minh Phuong, Truong Huu Hoang, Hitomi Sawai, Yoshitsugu Shiro, Misako Sato-Matsubara, Daisuke Oikawa, Fuminori Tokunaga, Katsutoshi Yoshizato, Norifumi Kawada
Publikováno v:
Redox Biology, Vol 52, Iss , Pp 102286- (2022)
Background & aims: Hepatic stellate cells (HSCs) are the primary cell type in liver fibrosis, a significant global health care burden. Cytoglobin (CYGB), a globin family member expressed in HSCs, inhibits HSC activation and reduces collagen productio
Externí odkaz:
https://doaj.org/article/b3caf10566394e3283c064a7fac5dd97
Publikováno v:
Antioxidants, Vol 12, Iss 2, p 350 (2023)
Protein ubiquitination, which is catalyzed by ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin ligases, is a crucial post-translational modification to regulate numerous cellular functions in a spatio–temporal-specific man
Externí odkaz:
https://doaj.org/article/528bec91e89c4604b4b804195c7f4ed1
Autor:
Osamu Nakabayashi, Hirotaka Takahashi, Kenta Moriwaki, Sachiko Komazawa-Sakon, Fumiaki Ohtake, Shin Murai, Yuichi Tsuchiya, Yuki Koyahara, Yasushi Saeki, Yukiko Yoshida, Soh Yamazaki, Fuminori Tokunaga, Tatsuya Sawasaki, Hiroyasu Nakano
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-19 (2021)
Nakabayashi et al find that the E3 ligase MIB2 ubiquitylates the apoptosis-inhibitor cFLIP and that deletion of MIB2 enhances both RIPK1 kinase-dependent and -independent apoptosis through an increase in RIPK1 kinase activity and impairment of ubiqui
Externí odkaz:
https://doaj.org/article/80d5d42aecbe4fc38a635136494386c1