Zobrazeno 1 - 10
of 657
pro vyhledávání: '"Fuming, Zhang"'
Publikováno v:
Microorganisms, Vol 12, Iss 9, p 1776 (2024)
Hepatitis B virus (HBV) infection remains a major health threat with limited treatment options. One of various new antiviral strategies is based on a fusion of Staphylococcus aureus nuclease (SN) with the capsid-forming HBV core protein (HBc), termed
Externí odkaz:
https://doaj.org/article/8062dc1761924874a3646ad76707d6e8
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/a66be25936fc49b7bd847f4cf34fe202
Publikováno v:
Antioxidants, Vol 13, Iss 6, p 679 (2024)
Statins are 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors widely used in the treatment of hyperlipidemia. The inhibition of HMG-CoA reductase in the mevalonate pathway leads to the suppression of cell proliferation and inductio
Externí odkaz:
https://doaj.org/article/13bdc474a470471d975d7e67e272be7f
Autor:
Jiyuan Yang, Yuefan Song, Ke Xia, Vitor H. Pomin, Chunyu Wang, Mingqiang Qiao, Robert J. Linhardt, Jonathan S. Dordick, Fuming Zhang
Publikováno v:
Marine Drugs, Vol 22, Iss 5, p 232 (2024)
Mycoplasma pneumoniae, a notable pathogen behind respiratory infections, employs specialized proteins to adhere to the respiratory epithelium, an essential process for initiating infection. The role of glycosaminoglycans, especially heparan sulfate,
Externí odkaz:
https://doaj.org/article/67ebfea3f0544ab5bdfa9a3a29c24e5e
Autor:
Biao Sun, Kai Zou, Yingqing Zhao, Yinfang Tang, Fuming Zhang, Weijing Chen, Xiaoting Tang, Chenran Chang, Yan Zheng
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionProteases exhibit a wide range of applications, and among them, alkaline proteases have become a prominent area of research due to their stability in highly alkaline environments. To optimize the production yield and activity of alkaline
Externí odkaz:
https://doaj.org/article/b6fd2ccf214742789c50207592dd24ae
Autor:
Paul S. Kwon, Shirley Xu, Hanseul Oh, Seok-Joon Kwon, Andre L. Rodrigues, Maisha Feroz, Keith Fraser, Peng He, Fuming Zhang, Jung Joo Hong, Robert J. Linhardt, Jonathan S. Dordick
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Suramin, a polysulfated synthetic drug, binds to the ACE2 receptor and heparan sulfate binding sites on SARS-CoV-2 RBDs with preferential binding for Omicron RBD and inhibition of infection by the Omicron variant in vitro.
Externí odkaz:
https://doaj.org/article/f9c4ce0ff01c4a649d774200f246e2fd
Autor:
Peng He, Xing Zhang, Ke Xia, Dixy E. Green, Sultan Baytas, Yongmei Xu, Truong Pham, Jian Liu, Fuming Zhang, Andrew Almond, Robert J. Linhardt, Paul L. DeAngelis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Heparin is a family of complex carbohydrates binding to proteins to modulate cell activities. Here the authors report the synthesis, and conformations simulations of S-linked hemi-A heparosan [GlcA-S-GlcNAc]n, a thio-glycosidic uncleavable polysaccha
Externí odkaz:
https://doaj.org/article/ef461400591343048c9e59e0041eaaf1
Autor:
Jiyuan Yang, Yuefan Song, Weihua Jin, Ke Xia, Grace C. Burnett, Wanjin Qiao, John T. Bates, Vitor H. Pomin, Chunyu Wang, Mingqiang Qiao, Robert J. Linhardt, Jonathan S. Dordick, Fuming Zhang
Publikováno v:
Viruses, Vol 16, Iss 2, p 237 (2024)
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells. Owing to its high negatively char
Externí odkaz:
https://doaj.org/article/a85e0c11f5ad435dbfcfef4089272a77
Publikováno v:
ACS Omega, Vol 7, Iss 8, Pp 7190-7198 (2022)
Externí odkaz:
https://doaj.org/article/417dd92b0b5149c7b42aa2c120b52aae
Autor:
Deling Shi, Peng He, Yuefan Song, Robert J. Linhardt, Jonathan S. Dordick, Lianli Chi, Fuming Zhang
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: The unexpected surge of respiratory syncytial virus (RSV) cases following pandemic phase of COVID-19 has drawn much public attention. Drawing on the latest antiviral research, revisiting this heightened annual outbreak of respiratory di
Externí odkaz:
https://doaj.org/article/5c07cb5c2fdd485d8d24e10316bafc3d