Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Fumiko YANO"'
Autor:
Kenta Makabe, Hiroyuki Okada, Naohiro Tachibana, Hisatoshi Ishikura, Norihito Ito, Masaru Tanaka, Ryota Chijimatsu, Asuka Terashima, Fumiko Yano, Meiko Asaka, Dai Yanagihara, Shuji Taketomi, Takumi Matsumoto, Sakae Tanaka, Yasunori Omata, Taku Saito
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-15 (2024)
Abstract Background Janus kinase (JAK) inhibitors, such as baricitinib, are widely used to treat rheumatoid arthritis (RA). Clinical studies show that baricitinib is more effective at reducing pain than other similar drugs. Here, we aimed to elucidat
Externí odkaz:
https://doaj.org/article/461b0b8b54354550a44697d5c2e340f5
Autor:
Kosei Nagata, Hironori Hojo, Song Ho Chang, Hiroyuki Okada, Fumiko Yano, Ryota Chijimatsu, Yasunori Omata, Daisuke Mori, Yuma Makii, Manabu Kawata, Taizo Kaneko, Yasuhide Iwanaga, Hideki Nakamoto, Yuji Maenohara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Yuki Taniguchi, Shinsuke Ohba, Ung-il Chung, Sakae Tanaka, Taku Saito
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Possible distinct contributions of Runx 2 and Runx3 in osteoarthritis have not been clarified. Nagata et al. show that Runx3 protects adult articular cartilage by extracellular matrix protein production in normal conditions, while Runx2 exerts both c
Externí odkaz:
https://doaj.org/article/b059fa273043489bbaaa2d7308967112
Autor:
Fumiko Yano, Taiga Takeda, Takafumi Kurokawa, Toshiya Tsubaki, Ryota Chijimatsu, Keita Inoue, Shinsaku Tsuji, Sakae Tanaka, Taku Saito
Publikováno v:
Regenerative Therapy, Vol 20, Iss , Pp 72-77 (2022)
Introduction: Cell therapy using adipose-derived mesenchymal stem cells (ASCs) is a promising avenue of regenerative medicine for the treatment of various diseases. It has been considered that ASCs exert their therapeutic effects through the secretio
Externí odkaz:
https://doaj.org/article/8f9cb13c4cba42dcb2642dc558d47432
Autor:
Junya Higuchi, Ryota Yamagami, Takumi Matsumoto, Tomohiro Terao, Keita Inoue, Shinsaku Tsuji, Yuji Maenohara, Tokio Matsuzaki, Ryota Chijimatsu, Yasunori Omata, Fumiko Yano, Sakae Tanaka, Taku Saito
Publikováno v:
Regenerative Therapy, Vol 14, Iss , Pp 332-340 (2020)
Introduction: Clinical studies of intra-articular injection of mesenchymal stem cells for osteoarthritis (OA) indicate its efficacy. Here, we retrospectively investigated the associations of pretherapeutic magnetic resonance imaging (MRI) findings wi
Externí odkaz:
https://doaj.org/article/d29fcd965b7049c28b46d3016a501866
Autor:
Shuichi Hamamoto, Ryota Chijimatsu, Kazunori Shimomura, Masato Kobayashi, George Jacob, Fumiko Yano, Taku Saito, Ung-il Chung, Sakae Tanaka, Norimasa Nakamura
Publikováno v:
Journal of Experimental Orthopaedics, Vol 7, Iss 1, Pp 1-14 (2020)
Abstract Purpose Chondrocyte -based tissue engineering has been a promising option for the treatment of cartilage lesions. In previous literature, TD198946 has been shown to promote chondrogenic differentiation which could prove useful in cartilage r
Externí odkaz:
https://doaj.org/article/97516ebd8940434dae4b1599a52ce5df
Autor:
Fengjun Xuan, Fumiko Yano, Daisuke Mori, Ryota Chijimatsu, Yuji Maenohara, Hideki Nakamoto, Yoshifumi Mori, Yuma Makii, Takeshi Oichi, Makoto Mark Taketo, Hironori Hojo, Shinsuke Ohba, Ung-il Chung, Sakae Tanaka, Taku Saito
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-11 (2019)
Abstract Background Both loss- and gain-of-function of Wnt/β-catenin signaling in chondrocytes result in exacerbation of osteoarthritis (OA). Here, we examined the activity and roles of Wnt/β-catenin signaling in the superficial zone (SFZ) of artic
Externí odkaz:
https://doaj.org/article/e2aa9cb1efc747c8a4b1193e7c631b85
Autor:
Manabu Kawata, Daisuke Mori, Kosuke Kanke, Hironori Hojo, Shinsuke Ohba, Ung-il Chung, Fumiko Yano, Hideki Masaki, Makoto Otsu, Hiromitsu Nakauchi, Sakae Tanaka, Taku Saito
Publikováno v:
Stem Cell Reports, Vol 13, Iss 3, Pp 530-544 (2019)
Summary: A simple induction protocol to differentiate chondrocytes from pluripotent stem cells (PSCs) using small-molecule compounds is beneficial for cartilage regenerative medicine and mechanistic studies of chondrogenesis. Here, we demonstrate tha
Externí odkaz:
https://doaj.org/article/2dc64c25609b46b1a78010c2c0ad39fe
Autor:
Song Ho Chang, Daisuke Mori, Hiroshi Kobayashi, Yoshifumi Mori, Hideki Nakamoto, Keita Okada, Yuki Taniguchi, Shurei Sugita, Fumiko Yano, Ung-il Chung, Joo-ri Kim-Kaneyama, Motoko Yanagita, Aris Economides, Ernesto Canalis, Di Chen, Sakae Tanaka, Taku Saito
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Excessive mechanical stress promotes the development of osteoarthritis. Here Chang et al. identify gremlin-1 as a factor expressed in chondrocytes in response to mechanical stress, and contributing to osteoarthritis via activation of the NF-κB pathw
Externí odkaz:
https://doaj.org/article/89ba19c2f9a9477294c478b865fc68cf
Publikováno v:
Bone Reports, Vol 14, Iss , Pp 100920- (2021)
Externí odkaz:
https://doaj.org/article/74abe037d9f54687b824f3e8a34a8d04
Autor:
Yasuyuki Fujii, Yoko Kawase-Koga, Hironori Hojo, Fumiko Yano, Marika Sato, Ung-il Chung, Shinsuke Ohba, Daichi Chikazu
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-12 (2018)
Abstract Background Human dental pulp stem cells (DPSCs), which have the ability to differentiate into multiple lineages, were recently identified. DPSCs can be collected readily from extracted teeth and are now considered to be a type of mesenchymal
Externí odkaz:
https://doaj.org/article/46155f244f5e43f790ab446c01ba0bcb