Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Fumiko Ninomiya"'
Autor:
Keisuke Yamamura, Fumiko Ninomiya, Kenji Matsubara, Hiromi Yamamoto, Takamasa Suzuki, Naomoto Harada, Shuichi Ohkubo, Haruka Nagasaki
Publikováno v:
Journal of Toxicologic Pathology. 34:359-365
To generate a mouse glioblastoma model by genome editing, we introduced Cas9 protein and guide RNAs specific for Nf1, Pten, and Trp53 into the neonatal mouse forebrain by electroporation. We found a high incidence (approximately 90%) of glial tumor d
Autor:
Nozomi Hashimoto, Sosuke Kishi, Kousuke Saoo, Masanao Yokohira, Yuko Nakano, Keiko Yamakawa, Katsumi Imaida, Shohei Kanie, Fumiko Ninomiya
Publikováno v:
Experimental and Toxicologic Pathology. 66:391-401
Chronic inflammatory effects of single intratracheal instillation (i.t.) of quartz on rat lung tumorigenesis were examined using 4 different animal models. At first, in order to determine an appropriate dose of quartz i.t. to promote lung tumorigenes
Autor:
Katsumi Imaida, Sosuke Kishi, Kousuke Saoo, Yuko Nakano, Masanao Yokohira, Fumiko Ninomiya, Keiko Yamakawa, Junko Tanizawa, Shigemi Kinouch
Publikováno v:
Experimental and Toxicologic Pathology. 66:117-123
There are 2 types of bronchiolo-alveolar hyperplasia found in rat lungs. One is 'inflammatory hyperplasia' with a potential to recover in future with removal of the stimulating insult and the other is 'latent tumorigenic hyperplasia' as an independen
Autor:
Keiko Yamakawa, Sosuke Kishi, Hiroko Hitotsumachi, Shohei Kanie, Katsumi Imaida, Fumio Furukawa, Fumiko Ninomiya, Kousuke Saoo, Masanao Yokohira, Yuko Nakano, Takamasa Numano
Publikováno v:
Journal of Toxicologic Pathology
Surfactant proteins (SPs), originally known as human lung surfactants, are essential to respiratory structure and function. There are 4 subtypes, SP-A, SP-B, SP-C and SP-D, with SP-A and SP-D having immunological functions, and SP-B and SP-C having p
Autor:
Fumiko Ninomiya, Sosuke Kishi, Masanao Yokohira, Katsumi Imaida, Yuko Nakano, Keiko Yamakawa, Tatsushi Inoue, Toshiya Kuno
Publikováno v:
Oncology Reports
The present study was conducted to investigate the effects of gonadectomy on lung carcinogenesis in female and male mice, and to determine an association between sex hormone and lung carcinogenesis. Female and male A/J mice were divided into gonadect
Publikováno v:
Journal of Toxicologic Pathology
Spontaneous thymoma was found in the left lobe of the thymus of a male 10-week-old Sprague-Dawley (SD) rat. Microscopically, the thymic mass showed a sheet of dark area with multiple pale foci. The dark area mainly consisted of densely compacted smal
Autor:
Nozomi Hashimoto, Katsumi Imaida, Suzuki Satoshi, Keiko Yamakawa, Masanao Yokohira, Fumiko Ninomiya, Toshiya Kuno, Kousuke Saoo
Publikováno v:
Journal of Toxicologic Pathology
It is an urgent priority to establish in vivo bioassays for detection of hazards related to fine particles, which can be inhaled into deep lung tissue by humans. In order to establish an appropriate bioassay for detection of lung damage after particl
Autor:
Toshitaka Nakagawa, Masanao Yokohira, Nozomi Hashimoto, Sosuke Kishi, Fumiko Ninomiya, Katsumi Imaida, Yuko Nakano, Shohei Kanie, Keiko Yamakawa, Kousuke Saoo
Publikováno v:
International journal of toxicology. 34(4)
The present study was conducted to examine the chronic effects of potassium octatitanate fibers (trade name TISMO; chemical formula K2O·6TiO2) on the mouse lung and thoracic cavity. This method of infusion was employed to examine the direct effects
Autor:
Kimiko Esaki, Kousaku Murata, Fumiko Ninomiya, Shigeo Aibara, Katsumi Shibata, Kumiko Hisaki, Takahiko Higasa
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 60:1444-1449
Treating bread dough by a high-voltage electric field (HVEF) during the first fermentation enabled the bread dough to retain water in the gluten fibers. The microstructure of the gluten fibers was ...
Autor:
Sosuke Kishi, Masanao Yokohira, Yuko Nakano, Katsumi Imaida, Fumiko Ninomiya, Keiko Yamakawa, Kousuke Saoo
Publikováno v:
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 65(6)
Although we have previously reported that the fiber-shaped TISMO, morphologically similar to asbestos, can induce a severe mesothelial reaction in A/J mice, it is important to clarify any strain differences. In the present study, female A/J, C3H/HeN,