Výsledky vyhledávání - "Fumiko, TAKADA"

Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control

Autor: Qiang Liu, Emily Sever, Sreenivasan Paruthiyil, Ana G Lujan Hernandez, Aaron K. Sato, Fumiko Takada Axelrod, Joyce Lai, Tom Z. Yuan, Greg Szot, Burcu Hasdemir, Pankaj Garg, Linya Wang, Emily Tuscano, Eric Kwan, Erica Keane

Publikováno v: mAbs
article-version (VoR) Version of Record

G protein-coupled receptors (GPCRs) are a group of seven-transmembrane receptor proteins that have proven to be successful drug targets. Antibodies are becoming an increasingly promising modality to target these receptors due to their unique properti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1931afd066241b8c67b73ff70853c556
http://europepmc.org/articles/PMC7971233

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Rapid exploration of the epitope coverage produced by an Ebola survivor to guide the discovery of therapeutic antibody cocktails

Autor: Tom Z. Yuan, Mohammad Javad Aman, Fumiko Takada Axelrod, Erica Keane, Aaron K. Sato, Yasmina N Abdiche, Madeleine Noonan-Shueh, Qiang Liu, Shweta Kailasan, Ana G Lujan Hernandez

Publikováno v: Antibody Therapeutics

Background Development of successful neutralizing antibodies is dependent upon broad epitope coverage to increase the likelihood of achieving therapeutic function. Recent advances in synthetic biology have allowed us to conduct an epitope binning stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1b7602025d45b02896477579bd85bf
https://pubmed.ncbi.nlm.nih.gov/33912793

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Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

Publikováno v: Proceedings of the National Academy of Sciences. 109:11717-11722

The Wnt/β-catenin pathway, which signals through the Frizzled (Fzd) receptor family and several coreceptors, has long been implicated in cancer. Here we demonstrate a therapeutic approach to targeting the Wnt pathway with a monoclonal antibody, OMP-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbc7ac0f527fa9ea201aeb1476036c3
https://doi.org/10.1073/pnas.1120068109

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Abstract 70: Effect of aging on the antitumor activity of GITRL-Fc

Autor: Jenny Pokorny, Austin L. Gurney, Fumiko Takada Axelrod, Janice Yu, Rui Yun, Minu K. Srivastava, Angie Inkyung Park

Publikováno v: Cancer Research. 78:70-70

Mouse tumor models have been successfully used to generate preclinical data for numerous clinical programs including immunotherapy. Preclinical in vivo studies are typically carried out using young mice (often less than 2 months old) to generate effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a95cf85046e4dbe013eb2ea00a23f85
https://doi.org/10.1158/1538-7445.am2018-70

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Abstract 3826: GITRL-Fc biomarker and mechanism study: GITRL-Fc reduces Treg frequency in tumors and requires effector function for inhibition of tumor growth

Autor: Ming-Hong Xie, Fumiko Takada Axelrod, Belinda Cancilla, Ann M. Kapoun, Reyhaneh Lahmy, Alayne Brunner, Jorge Monteon, Gilbert O'Young, Rose Harris, Pete Yeung, Austin L. Gurney, Andrew Lam, Fiore Cattaruzza, Earth Light Lowe, Gretchen Argast, Jennifer Elechko, Min Wang, Erwan Le Scolan

Publikováno v: Cancer Research. 78:3826-3826

Activation of the co-stimulatory receptor GITR (Glucocorticoid-Induced Tumor Necrosis Factor Receptor) by GITR-Ligand (GITRL) promotes proliferation and activation of effector T cells (T eff) and inhibits suppressive activity of regulatory T cells (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e4558506ad0516bff1035a66dcf6c42
https://doi.org/10.1158/1538-7445.am2018-3826

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Abstract 5627: Anti-TIGIT biomarker study: Inhibition of TIGIT induces loss of Tregs from tumors and requires effector function for tumor growth inhibition

Autor: Fumiko Takada Axelrod, Rose Harris, Austin L. Gurney, Ming-Hong Xie, Pete Yeung, Ann M. Kapoun, Alayne Brunner, Reyhaneh Lahmy, Fiore Cattaruzza, Erwan Le Scolan, John Lewicki, Gilbert O'Young, Jorge Monteon, Andrew Lam, Belinda Cancilla, Min Wang, Earth Light Lowe, Gretchen Argast, Jennifer Elechko

Publikováno v: Cancer Research. 78:5627-5627

The immune checkpoint co-inhibitory receptor TIGIT (T cell immunoreceptor with Ig ITIM domain) is expressed on regulatory T cells (Tregs) and on activated CD4+ T, CD8+ T, and NK cells. We have reported that by blocking TIGIT activity with an IgG2a an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfe5af48895484af23edb76406e7bfd4
https://doi.org/10.1158/1538-7445.am2018-5627

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Abstract 2726: In vitro functional activity of OMP-336B11, a GITRL-Fc fusion protein, on primary human immune cells

Autor: Fumiko Takada Axelrod, Andrew Lam, Angie I. Park, Austin L. Gurney, Ivan H. Chan, Ming-Hong Xie, Jennifer Elechko

Publikováno v: Cancer Research. 78:2726-2726

Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNF receptor superfamily. GITR, a co-stimulatory surface receptor, is activated upon binding to GITR Ligand (GITRL) and mediates co-stimulation of T-cell and NK responses and inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93272071b5a3e94f1ea37af64c7f9791
https://doi.org/10.1158/1538-7445.am2018-2726

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Co-targeting of delta-like ligand 4 (DLL4) and vascular endothelial growth factor a (VEGF) with programmed death 1 (PD1) blockade inhibits tumor growth and facilitates anti-tumor immune responses

Autor: Fumiko Takada Axelrod, Austin L. Gurney, Christopher Murriel, Ann M. Kapoun, Hyun-Bae Jie, Rui Yun, Minu K. Srivastava, Trevor Bentley, Raymond Tam, Ming-Hong Xie, John Lewicki, Belinda Cancilla, Tim Hoey, Park Angie Inkyung, Erin Mayes, Gilbert O'Young

Publikováno v: Journal for Immunotherapy of Cancer

Meeting abstracts Blocking DLL4, a Notch ligand, effectively inhibits tumor growth by increasing non-functional angiogenesis and decreasing the cancer stem cell (CSC) population. Preclinical studies have demonstrated inhibition of tumor growth by ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca026670f3f6e1eea320228d8b902ed0
https://doi.org/10.1186/2051-1426-3-s2-p373

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Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types

Publikováno v: Cancer research. 76(3)

Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a range of human tumors, but the contribution of specific extracel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4118c1e33a7e59606a7685d6ff967c72
https://pubmed.ncbi.nlm.nih.gov/26719531

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