Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Fumikazu Wanibuchi"'
Autor:
Tetsuya Kimizuka, Kyoichi Maeno, Kenichi Kazuta, Yasuharu Kimura, Ken-ichi Hatanaka, Fumikazu Wanibuchi, Itsuro Shimada, Shin-ichi Tsukamoto, Hideki Kubota, Yuki Naitou, Shuichi Sakamoto
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:1966-1982
A series of novel indazole derivatives were synthesized, and their structure–activity relationships examined in order to identify potent and selective 5-HT2C receptor agonists. Among these compounds, (S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-met
Autor:
Kenichi Hatanaka, Kyoichi Maeno, Yasuharu Kimura, Tokio Yamaguchi, Yuki Naitou, Itsuro Shimada, Akiko Koakutsu, Fumikazu Wanibuchi
Publikováno v:
European Journal of Pharmacology. 483:37-43
YM348, (S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine, showed a high affinity for cloned human 5-HT(2C) receptors (K(i): 0.89 nM). The functional selectivity for 5-HT(2C) receptors in the 5-HT(2) receptor family was the highest among 5
Autor:
Tetsuo Kiso, Atsuyuki Kohara, Fumikazu Wanibuchi, Takashi Toya, Akihiko Iwai, Yukinori Nagakura, Masamichi Okada, Tokio Yamaguchi
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:490-497
The complete Freund's adjuvant (CFA)-induced arthritic rat model has extensively served as a laboratory model in the study of arthritic pain. However, the time courses of allodynia and hyperalgesia and the efficacies of different analgesics have not
Autor:
Igarashi Susumu, Fumikazu Wanibuchi, Toshinari Tamura, Kazuyuki Hidaka, Shin-ichi Tsukamoto, Hitoshi Nagaoka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:1523-1529
A series of novel 2, 8-dialykl-1-oxa-2, 8-diazaspiro[4.5]decan-3-ones and 2, 8-dimethyl-1, 2, 8-triazaspiro[4.5]-decan-3-one (13), related to M1 muscarinic agonists YM796 and RS86, were synthesized by using Michael addition reaction of hydroxyurea or
Autor:
Hiroshi Yamashita, Kazuyuki Hidaka, Shinji Usuda, Shin-ichi Tsukamoto, Takako Nishida, Kazuo Koshiya, Fumikazu Wanibuchi
Publikováno v:
European Journal of Pharmacology. 265:151-158
Previous reports have shown that (±)-YM796 (2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane) exhibits M 1 agonistic activity and ameliorates cognitive impairment, and that the (−)- S isomer is active in in vitro studies. We report here the ch
Autor:
Kazuyuki Hidaka, Masato Ichihara, Fumikazu Wanibuchi, Toshinari Tamura, Shinji Usuda, Masatomi Harada, Shin-ichi Tsukamoto
Publikováno v:
ChemInform. 24
A series of spirooxazolidine-2,4-dione derivatives related to the putative M1 agonist 2-ethyl-8-methyl-2,8-diazaspiro[4.5]decane-1,3-dione (RS86; 1) were synthesized. The compounds were evaluated as cholinergic agents in in vitro binding assays and i
Autor:
M. Fujii, Fumikazu Wanibuchi, T. Yasunaga, Toshinari Tamura, Shin-ichi Tsukamoto, T. Furuya, Kazuyuki Hidaka, K. Matsuda
Publikováno v:
ChemInform. 26
Autor:
Hitoshi Nagaoka, Kazuyuki Hidaka, Fumikazu Wanibuchi, Shin-ichi Tsukamoto, Toshinari Tamura, Igarashi Susumu
Publikováno v:
ChemInform. 27
A series of novel 2, 8-dialykl-1-oxa-2, 8-diazaspiro[4.5]decan-3-ones and 2, 8-dimethyl-1, 2, 8-triazaspiro[4.5]-decan-3-one (13), related to M1 muscarinic agonists YM796 and RS86, were synthesized by using Michael addition reaction of hydroxyurea or
Autor:
Fumikazu Wanibuchi, Itsuro Shimada, Kyoichi Maeno, Shin-ichi Tsukamoto, Ken-ichi Hatanaka, Yasuharu Kimura, Keizo Sugasawa, Yutaka Kondoh, Yuki Naitou, Shuichi Sakamoto, Hidetaka Kaku
Publikováno v:
Bioorganicmedicinal chemistry. 16(6)
To identify potent and selective 5-HT(2C) receptor agonists, a series of novel benzazepine derivatives were synthesized, and their structure-activity relationships examined. The compounds were evaluated for their 5-HT(2C), 5-HT(2A), and 5-HT(2B) rece
Publikováno v:
The Journal of urology. 175(5)
We investigated the effects of the novel 5-HT2C receptor agonist YM348 [(S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine] on ICP in anesthetized rats and clarified whether behavioral changes such as hypolocomotion induced at a high dose