Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Fumikazu OKAJIMA"'
Autor:
Shiori MUSHA, Saishu YOSHIDA, Syo MURAKAMI, Ryotaro KOJIMA, Masahito DEAI, Naoshi SASO, Chihiro MOGI, Koichi SATO, Fumikazu OKAJIMA, Hideaki TOMURA
Publikováno v:
The Journal of Reproduction and Development, Vol 66, Iss 2, Pp 175-180 (2020)
Hormone-secreting pituitary adenomas show unregulated hormonal hypersecretion and cause hyperpituitarism. However, the mechanism of the unregulated hormone production and secretion has not yet been fully elucidated. Solid tumors show reduced extracel
Externí odkaz:
https://doaj.org/article/319d50874f4241558f6c85e2aa75eb3a
Autor:
Maiko Kadowaki, Hidenori Yamada, Koichi Sato, Hiroko Shigemi, Yukihiro Umeda, Miwa Morikawa, Yuko Waseda, Masaki Anzai, Yosuke Kamide, Haruka Aoki-Saito, Takeshi Hisada, Fumikazu Okajima, Tamotsu Ishizuka
Publikováno v:
Journal of Inflammation, Vol 16, Iss 1, Pp 1-10 (2019)
Abstract Background Human airway smooth muscle cells (ASMCs) contribute to bronchial contraction and airway hyperresponsiveness in patients with bronchial asthma. They also generate cytokines, chemokines, and matricellular proteins. Ovarian cancer G
Externí odkaz:
https://doaj.org/article/d52dfb242eea450396749b5e55f6f267
Autor:
Akiomi Nagasaka, Chihiro Mogi, Hiroki Ono, Toshihide Nishi, Yuma Horii, Yuki Ohba, Koichi Sato, Michio Nakaya, Fumikazu Okajima, Hitoshi Kurose
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Myocardial infarction (MI) is an ischaemic heart condition caused by the occlusion of coronary arteries. Following MI, lactic acid from anaerobic glycolysis increases and infiltrating immune cells produce severe inflammation, which leads to
Externí odkaz:
https://doaj.org/article/79bdd7ecb0b44afb8eab5d5cabbfc604
Autor:
Yosuke M. Morizawa, Yuri Hirayama, Nobuhiko Ohno, Shinsuke Shibata, Eiji Shigetomi, Yang Sui, Junichi Nabekura, Koichi Sato, Fumikazu Okajima, Hirohide Takebayashi, Hideyuki Okano, Schuichi Koizumi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Astrocytic phagocytosis has been shown to play a role in synaptic pruning during development, but whether adult astrocytes possess phagocytic ability is unclear. Here the authors show that following brain ischemia, reactive astrocytes become phagocyt
Externí odkaz:
https://doaj.org/article/ae5888d09dbf4fd4aac1a32a1f9621b4
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178769 (2017)
Obesity is associated with an increased risk of diabetes mellitus, hypertension, and renal dysfunction. Angiotensin 1-7 and alamandine are heptameric renin angiotensin system peptide hormones. Further, alamandine levels increase with renal dysfunctio
Externí odkaz:
https://doaj.org/article/c9866bd35867422cb63cb499ee636098
Autor:
Ji-Yeong Jo, Hyo-Lim Kim, Yun-Kyung Lee, Hideaki Tomura, Yoe-Sik Bae, Fumikazu Okajima, Dong-Soon Im
Publikováno v:
Journal of Pharmacological Sciences, Vol 107, Iss 3, Pp 303-307 (2008)
Calcium is a ubiquitous second messenger that controls a broad range of cellular functions, and store-operated calcium entry (SOCE) is the primary mechanism of regulated Ca2+ entry in non-excitable immunocytes. In this study, we found that N,N-dimeth
Externí odkaz:
https://doaj.org/article/fb0cfd5abfee4d3b8039de77102477d9
Autor:
Tsuyoshi Uchiyama, Shoichi Tomono, Koichi Sato, Tetsuya Nakamura, Masahiko Kurabayashi, Fumikazu Okajima
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139638 (2015)
Metabolic syndrome is characterized by visceral adiposity, insulin resistance, high triglyceride (TG)- and low high-density lipoprotein cholesterol-levels, hypertension, and diabetes-all of which often cause cardiovascular and cerebrovascular disease
Externí odkaz:
https://doaj.org/article/4f507e7f86d54e2ea971c4ed86a4ab45
Autor:
Ayaka Tobo, Masayuki Tobo, Takashi Nakakura, Masashi Ebara, Hideaki Tomura, Chihiro Mogi, Dong-Soon Im, Naoya Murata, Atsushi Kuwabara, Saki Ito, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto, Michio Nakaya, Hitoshi Kurose, Koichi Sato, Fumikazu Okajima
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129334 (2015)
G protein-coupled receptor 4 (GPR4), previously proposed as the receptor for sphingosylphosphorylcholine, has recently been identified as the proton-sensing G protein-coupled receptor (GPCR) coupling to multiple intracellular signaling pathways, incl
Externí odkaz:
https://doaj.org/article/9cf59e4d2f3f49efb7bde40467363339
Publikováno v:
Journal of Pharmacological Sciences, Vol 100, Iss 4, Pp 289-296 (2006)
Abstract.: Dimethylsphingosine (DMS) was first reported as an inhibitor of protein kinase C and later has been used as a specific inhibitor of sphingosine kinase. Furthermore, its anti-cancer effect has become a basis for development of chemotherapy.
Externí odkaz:
https://doaj.org/article/392cb3bc2b6b44a28293fc1e1eb6ac7e
Autor:
Young-Jin Im, Dong-Soon Im, Yun-Kyung Lee, Eun-Hee Lee, Koichi Sato, Hideaki Tomura, Toshiaki Katada, Michio Ui, Fumikazu Okajima
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 3, Pp 443-446 (2005)
Sphingosine-1-phosphate (S1P) acts on a set of G protein-coupled receptors in the plasma membrane and also as a second messenger in certain cell types. There are two possible pathways to mobilize intracellular Ca2+ concentration by S1P. One is throug
Externí odkaz:
https://doaj.org/article/3329e06e16ac46939b3cabb1f09fc791