Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Fumika Sakaue"'
Autor:
Juri Hasegawa, Tetsuya Nagata, Kensuke Ihara, Jun Tanihata, Satoe Ebihara, Kie Yoshida-Tanaka, Mitsugu Yanagidaira, Masahiro Ohara, Asuka Sasaki, Miyu Nakayama, Syunsuke Yamamoto, Takashi Ishii, Rintaro Iwata-Hara, Mitsuru Naito, Kanjiro Miyata, Fumika Sakaue, Takanori Yokota
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The approval of splice-switching oligonucleotides with phosphorodiamidate morpholino oligomers (PMOs) for treating Duchenne muscular dystrophy (DMD) has advanced the field of oligonucleotide therapy. Despite this progress, PMOs encounter cha
Externí odkaz:
https://doaj.org/article/acc57f07774342059f02713bd8b500a9
Autor:
Daisuke Ono, Ken Asada, Daishi Yui, Fumika Sakaue, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 1360-1370 (2021)
DNA/RNA heteroduplex oligonucleotide (HDO), composed of DNA/locked nucleic acid (LNA) antisense oligonucleotide (ASO) and complementary RNA, is a next-generation antisense therapeutic agent. HDO is superior to the parental ASO in delivering to target
Externí odkaz:
https://doaj.org/article/6476e126391545d09058e588e4ffbb20
Autor:
Tsutomu Nakamura, Fumika Sakaue, Yukiko Nasu-Nishimura, Yasuko Takeda, Ken Matsuura, Tetsu Akiyama
Publikováno v:
EBioMedicine, Vol 34, Iss , Pp 189-200 (2018)
GABAergic dysfunction underlies many neurodevelopmental and psychiatric disorders. GABAergic synapses exhibit several forms of plasticity at both pre- and postsynaptic levels. NMDA receptor (NMDAR)–dependent inhibitory long-term potentiation (iLTP)
Externí odkaz:
https://doaj.org/article/e755f80472964f689b4a4c7f8177f4c2
Autor:
Tsutomu Nakamura, Fumiko Arima-Yoshida, Fumika Sakaue, Yukiko Nasu-Nishimura, Yasuko Takeda, Ken Matsuura, Natacha Akshoomoff, Sarah N. Mattson, Paul D. Grossfeld, Toshiya Manabe, Tetsu Akiyama
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The molecular underpinning of autism is unclear. Here the authors show PX-RICS deficient mice exhibit autism-like social behavioural abnormalities and impaired GABAA receptor trafficking, and enhancing inhibitory synaptic transmission with a GABAArec
Externí odkaz:
https://doaj.org/article/111e3b7f27194d44a435bfedacde52eb
Autor:
Rashaun S. Wilson, Navin Rauniyar, Fumika Sakaue, TuKiet T. Lam, Kenneth R. Williams, Angus C. Nairn
Publikováno v:
Proteomes, Vol 7, Iss 2, p 12 (2019)
The postsynaptic density (PSD) is a structural, electron-dense region of excitatory glutamatergic synapses, which is involved in a variety of cellular and signaling processes in neurons. The PSD is comprised of a large network of proteins, many of wh
Externí odkaz:
https://doaj.org/article/933bdb2d2738419bb0247bd1e8ccb9f2
Autor:
Motoki Miura, Fumika Sakaue, Hirokazu Matsuno, Kento Morita, Akiko Yoshida, Rintaro Iwata Hara, Ren Nishimura, Yurika Nishida, Mariko Yokogawa, Masanori Osawa, Takanori Yokota
Publikováno v:
FEBS Letters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05b07a08881ed088b3675bb49639868b
https://doi.org/10.1002/1873-3468.14635
https://doi.org/10.1002/1873-3468.14635
Autor:
Daishi Yui, Kotaro Yoshioka, Takanori Yokota, Ken Asada, Daisuke Ono, Tetsuya Nagata, Fumika Sakaue
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 1360-1370 (2021)
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 1360-1370 (2021)
DNA/RNA heteroduplex oligonucleotide (HDO), composed of DNA/locked nucleic acid (LNA) antisense oligonucleotide (ASO) and complementary RNA, is a next-generation antisense therapeutic agent. HDO is superior to the parental ASO in delivering to target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cae267b886ce30049e1532a7566fbc
https://doi.org/10.1016/j.omtn.2020.11.022
https://doi.org/10.1016/j.omtn.2020.11.022
Autor:
Masayuki Kaneko, Koji Matsuhisa, Yuka Kimura, Rie Asada, Atsushi Saito, Kazunori Imaizumi, Yan Wu, Fumika Sakaue, Takumi Okamoto
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
RNF183 is a ubiquitin ligase containing RING-finger and transmembrane domains, and its expression levels are increased in patients with inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, and in 2,4,6-trinitrobenzene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29124c4e37aaf23f9379819f7609a182
http://link.springer.com/article/10.1038/s41598-019-56748-6
http://link.springer.com/article/10.1038/s41598-019-56748-6
Autor:
Takumi Okamoto, Longjie Cai, Keiichi I. Nakayama, Masayasu Okochi, Koji Matsuhisa, Fumika Sakaue, Rie Asada, Kazunori Imaizumi, Masaki Matsumoto, Kanta Yanagida, Masayuki Kaneko, Atsushi Saito, Fumihiko Urano, Yukitsuka Kudo
Publikováno v:
The FASEB Journal. 34:865-880
Intramembrane cleavage of transmembrane proteins is a fundamental cellular process to produce important signals that elicit biological responses. These proteolytic events are known as regulated intramembrane proteolysis (RIP). ATF6 and BBF2H7 are tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fd3eda7e197562d7ba9f3dd34b05b7
https://doi.org/10.1096/fj.201901748r
https://doi.org/10.1096/fj.201901748r
Autor:
Takanori Yokota, Ken Asada, Kie Yoshida-Tanaka, Tetsuya Nagata, Makiko Nawa, Aya Abe, Kazutaka Nishina, Ji-Chun Zhang, Fumika Sakaue
Publikováno v:
Nucleic Acids Research
Antisense oligonucleotide (ASO)-based therapy is one of the next-generation therapy, especially targeting neurological disorders. Many cases of ASO-dependent gene expression suppression have been reported. Recently, we developed a tocopherol conjugat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f51374571369db035572aec8cc1dde
https://pubmed.ncbi.nlm.nih.gov/33928345
https://pubmed.ncbi.nlm.nih.gov/33928345