Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Fumihito Ushiyama"'
Autor:
Fumihito Ushiyama, Hideaki Amada, Tomoki Takeuchi, Nozomi Tanaka-Yamamoto, Harumi Kanazawa, Koichiro Nakano, Masashi Mima, Aiko Masuko, Iichiro Takata, Kosuke Hitaka, Kunihiko Iwamoto, Hiroyuki Sugiyama, Norikazu Ohtake
Publikováno v:
ACS Omega, Vol 5, Iss 17, Pp 10145-10159 (2020)
Externí odkaz:
https://doaj.org/article/17fa358e19ce435eaf8d3e740e6f6ab1
Autor:
Aiko Masuko, Hiroyuki Sugiyama, Fumihito Ushiyama, Harumi Kanazawa, Koichiro Nakano, Norikazu Ohtake, Masashi Mima, Kosuke Hitaka, Hideaki Amada, Takeuchi Tomoki, Nozomi Tanaka-Yamamoto, Kunihiko Iwamoto, Iichiro Takata
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 17, Pp 10145-10159 (2020)
ACS Omega, Vol 5, Iss 17, Pp 10145-10159 (2020)
DNA gyrase and topoisomerase IV are well-validated pharmacological targets, and quinolone antibacterial drugs are marketed as their representative inhibitors. However, in recent years, resistance to these existing drugs has become a problem, and new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ab8f6fd6bd3f2be8c5a152b9adb049
https://doi.org/10.1021/acsomega.0c00865
https://doi.org/10.1021/acsomega.0c00865
Autor:
Fumihito Ushiyama1 f-ushiyama@jaist.ac.jp, Naoshi Uchihira1 uchihira@jaist.ac.jp
Publikováno v:
Proceedings of ISPIM Conferences. 2017, p1-13. 13p. 3 Diagrams, 2 Charts, 7 Graphs.
Autor:
Iichiro Takata, Aiko Masuko, Hiroyuki Sugiyama, Fumihito Ushiyama, Hirotoshi Okumura, Hideaki Amada, Kiyoko Fujita
Publikováno v:
Antimicrob Agents Chemother
Gonorrhea is a common, sexually transmitted disease caused by Neisseria gonorrhoeae. Multidrug-resistant N. gonorrhoeae is an urgent threat, and the development of a new antimicrobial agent that functions via a new mechanism is strongly desired. We e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3cbf3df7c907d819a3c3bc22ce9e09
https://europepmc.org/articles/PMC8097434/
https://europepmc.org/articles/PMC8097434/
Autor:
Yuya Ogata, Harumi Kanazawa, Macias Alba, Norikazu Ohtake, Allan E. Surgenor, Iichiro Takata, Hajime Takashima, Walmsley David, Kiyoko Fujita, Hayley Angove, Kunihiko Iwamoto, Masashi Mima, Hiroyuki Sugiyama, Fumihito Ushiyama, Junya Yamagishi, Yousuke Yamada, Alan P. Robertson, Kosuke Hitaka, Koichiro Nakano, Hayato Watanabe, Atsushi Okada, Yohei Matsuda, Roderick E. Hubbard, Nozomi Tanaka-Yamamoto, Toru Yamaguchi-Sasaki, Risa Kurimoto-Tsuruta, Lisa Baker, Akihiro Tanaka, R. Harris
Publikováno v:
Journal of medicinal chemistry. 63(23)
UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is a zinc metalloenzyme that catalyzes the first committed step in the biosynthesis of Lipid A, an essential component of the cell envelope of Gram-negative bacteria. The most advanced, disclosed Lp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019ee8a95fea26f38a355f0054fb803d
https://pubmed.ncbi.nlm.nih.gov/33210531
https://pubmed.ncbi.nlm.nih.gov/33210531
Autor:
Yuya Ogata, Nozomi Tanaka-Yamamoto, Naoki Sasamoto, Iichiro Takata, Katsumasa Otake, Hajime Takashima, Yohei Matsuda, Haruhiro Yamashita, Mayumi Endo, Kiyoko Fujita, Kaori Ueki, Masashi Mima, Satoshi Tsuji, Hirotoshi Okumura, Hiroyuki Sugiyama, Fumihito Ushiyama, Risa Kurimoto-Tsuruta
Publikováno v:
Bioorganicmedicinal chemistry. 30
Infectious diseases caused by resistant Gram-negative bacteria have become a serious problem, and the development of therapeutic drugs with a novel mechanism of action and that do not exhibit cross-resistance with existing drugs has been earnestly de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5917a1ea67529b22ac1ee7b5021a36ec
https://pubmed.ncbi.nlm.nih.gov/33385955
https://pubmed.ncbi.nlm.nih.gov/33385955
Autor:
Mayumi Endo, Hideaki Amada, Masafumi Kamitani, Takeuchi Tomoki, Norikazu Ohtake, Yunoshin Tamura, Aiko Masuko, Nozomi Tanaka-Yamamoto, Hiroyuki Sugiyama, Fumihito Ushiyama, Yasuhiro Mihara, Kosuke Hitaka, Iichiro Takata, Reiko Wada, Masashi Mima
Publikováno v:
Bioorganicmedicinal chemistry. 28(22)
The global increase in multidrug-resistant pathogens has caused severe problems in the treatment of infections. To overcome these difficulties, the advent of a new chemical class of antibacterial drug is eagerly desired. We aimed at creating novel an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c778902e9c7dd887132f2d7e97ce1d0
https://pubmed.ncbi.nlm.nih.gov/33032189
https://pubmed.ncbi.nlm.nih.gov/33032189