Výsledky vyhledávání - "Fumihiro Nakamori"

Discovery of tricyclic dipyrrolopyridine derivatives as novel JAK inhibitors

Autor: Hiroyuki Usuda, Fumihiro Nakamori, Takayuki Inoue, Hiroaki Tominaga, Yutaka Nakajima, Masamichi Inami, Ayako Moritomo, Misato Ito, Jun Maeda, Takeshi Hondo, Yasuyuki Higashi, Hiroki Morio, Koji Nakamura, Shohei Shirakami, Hiroaki Yamagishi

Publikováno v: Bioorganic & Medicinal Chemistry. 25:5311-5326

Janus kinases (JAKs) play a crucial role in cytokine mediated signal transduction. JAK inhibitors have emerged as effective immunomodulative agents for the prevention of transplant rejection. We previously reported that the tricyclic imidazo-pyrrolop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da8d29d1bb301d7f81be2fd50ffa9c1
https://doi.org/10.1016/j.bmc.2017.07.043

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Mechanical and thermal properties of ZrSiO4

Autor: Yuji Ohishi, Ken-ichi Fukumoto, Fumihiro Nakamori, Shinsuke Yamanaka, Hiroaki Muta, Ken Kurosaki

Publikováno v: Journal of Nuclear Science and Technology. 54:1267-1273

In order to conduct defueling operations for the decommissioning of the reactor at the Fukushima Daiichi nuclear power plant, an understanding of the physical properties of ZrSiO4 is of extreme imp...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29ed2d17b6376f95c3c58307d2cfb997
https://doi.org/10.1080/00223131.2017.1359117

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Physical properties of core-concrete systems: Al 2 O 3 -ZrO 2 molten materials measured by aerodynamic levitation

Autor: Ken Kurosaki, Hiroaki Muta, Yuji Ohishi, Florian Kargl, Shinsuke Yamanaka, Fumihiro Nakamori

Publikováno v: Journal of Nuclear Materials. 487:121-127

During a molten core–concrete interaction, molten oxides consisting of molten core materials (UO2 and ZrO2) and concrete (Al2O3, SiO2, CaO) are formed. Reliable data on the physical properties of the molten oxides will allow us to accurately predic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fc545e332dc6688beab4c1e09fef9b
https://doi.org/10.1016/j.jnucmat.2017.02.002

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Mechanical and thermal properties of bulk ZrB2

Autor: Hiroaki Muta, Yuji Ohishi, Ken-ichi Fukumoto, Ken Kurosaki, Shinsuke Yamanaka, Fumihiro Nakamori

Publikováno v: Journal of Nuclear Materials. 467:612-617

ZrB 2 appears to have formed in the fuel debris at the Fukushima Daiichi nuclear disaster site, through the reaction between Zircaloy cladding materials and the control rod material B 4 C. Since ZrB 2 has a high melting point of 3518 K, the ceramic h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06f2ec2884d8322c24e1736b8ecda057
https://doi.org/10.1016/j.jnucmat.2015.10.024

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Species differences in intestinal glucuronidation activities between humans, rats, dogs and monkeys

Autor: Katsuhiro Yamano, Fumihiro Nakamori, Takako Furukawa, Kazuhiro Tetsuka, Yoichi Naritomi, Kenji Tabata, Shigeyuki Terashita, Hiroyuki Moriguchi, Toshio Teramura

Publikováno v: Xenobiotica. 44:205-216

1. Glucuronidation via UDP-glucuronosyltransferase (UGT) in the intestine has been reported to influence the pharmacokinetics (PK) of drugs; however, information concerning the differences in activity between species is limited. Here, we investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b324ea8abae398918b916abdb3b4086
https://doi.org/10.3109/00498254.2013.828362

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Design, synthesis, and evaluation of 4,6-diaminonicotinamide derivatives as novel and potent immunomodulators targeting JAK3

Autor: Takayuki Inoue, Hiroshi Sasaki, Fumie Takahashi, Fumihiro Nakamori, Masamichi Inami, Yutaka Nakajima, Misato Ito, Koji Nakamura, Naohiro Aoyama, Keiko Hatanaka, Shohei Shirakami, Ayako Moritomo

Publikováno v: Bioorganicmedicinal chemistry. 24(19)

In organ transplantation, T cell-mediated immune responses play a key role in the rejection of allografts. Janus kinase 3 (JAK3) is specifically expressed in hematopoietic cells and associated with regulation of T cell development via interleukin-2 s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01f9171ac1180536b424b8a3883c6e0
https://pubmed.ncbi.nlm.nih.gov/27544589

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Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data

Autor: Katsuhiro Yamano, Keitaro Kadono, Hiroyuki Moriguchi, Fumihiro Nakamori, Shigeyuki Terashita, Yoichi Naritomi, Toshio Teramura, Kazuhiro Tetsuka, Ken Ichi Hosoya, Takako Furukawa

Publikováno v: Drug Metabolism and Disposition. 40:1771-1777

We investigated whether the effects of intestinal glucuronidation on the first-pass effect can be predicted from in vitro data for UDP-glucuronosyltransferase (UGT) substrates. Human in vitro intrinsic glucuronidation clearance (CL(int, UGT)) for 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b695ba66971d2a4ca20d2cb3e7fff315
https://doi.org/10.1124/dmd.112.045476

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Quantitative Prediction of Intestinal Glucuronidation of Drugs in Rats Using In Vitro Metabolic Clearance Data

Autor: Katsuhiro Yamano, Toshio Teramura, Kazuhiro Tetsuka, Fumihiro Nakamori, Shigeyuki Terashita, Takako Furukawa, Yoichi Naritomi, Hiroyuki Moriguchi

Publikováno v: Drug Metabolism and Pharmacokinetics. 27:171-180

UDP-glucuronosyltransferase (UGT) is highly expressed in the small intestine and catalyzes the glucuronidation of small molecules, which may affect the oral bioavailability of drugs. However, no method of predicting the in vivo observed fraction of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243e6d305431c25a81a479df4ed414af
https://doi.org/10.2133/dmpk.dmpk-11-rg-088

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Correlation of Intrinsic in vitro and in vivo Clearance for Drugs Metabolized by Hepatic UDP-glucuronosyltransferases in Rats

Autor: Shigeyuki Terashita, Fumihiro Nakamori, Fujiko Takamura, Hiroya Miura, Hidetsugu Murai, Toshio Teramura, Yoichi Naritomi, Masako Furutani

Publikováno v: Drug Metabolism and Pharmacokinetics. 26:465-473

A method for quantitatively predicting the hepatic clearance of drugs by UDP-glucuronosyltransferases (UGTs) from in vitro data has not yet been established. We examined the relationship between in vitro and in vivo intrinsic clearance by rat hepatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3eb38abd5b7b9dde89ce2b308670508
https://doi.org/10.2133/dmpk.dmpk-11-rg-018

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