Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Fumihiro, Kawagoe"'
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 37 (2023)
Our research regarding side-chain fluorinated vitamin D3 analogues has explored a series of efficient fluorination methods. In this study, a new electrophilic stereo-selective fluorination methodology at C24 and C22 positions of the vitamin D3 side-c
Externí odkaz:
https://doaj.org/article/962d127e64b6473dabf975f06e166e14
Autor:
Fumihiro Kawagoe, Kaori Yasuda, Sayuri Mototani, Toru Sugiyama, Motonari Uesugi, Toshiyuki Sakaki, Atsushi Kittaka
Publikováno v:
ACS Omega, Vol 4, Iss 6, Pp 11332-11337 (2019)
Externí odkaz:
https://doaj.org/article/2c9112394dd8460db46e56762c130f84
Autor:
Sayuri Mototani, Fumihiro Kawagoe, Kaori Yasuda, Hiroki Mano, Toshiyuki Sakaki, Atsushi Kittaka
Publikováno v:
Molecules, Vol 27, Iss 16, p 5352 (2022)
In this paper, we report an efficient synthetic route for the 23,23-difluoro-25-hydroxyvitamin D3 (5) and its 24-hydroxylated analogues (7,8), which are candidates for the CYP24A1 main metabolites of 5. The key fragments, 23,23-difluoro-CD-ring precu
Externí odkaz:
https://doaj.org/article/3fe0d8b40b954d64881c01047bf1b804
Autor:
Fumihiro Kawagoe, Sayuri Mototani, Kaori Yasuda, Hiroki Mano, Toshiyuki Sakaki, Atsushi Kittaka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11863 (2021)
Two 24-fluoro-25-hydroxyvitamin D3 analogues (3,4) were synthesized in a convergent manner. The introduction of a stereocenter to the vitamin D3 side-chain C24 position was achieved via Sharpless dihydroxylation, and a deoxyfluorination reaction was
Externí odkaz:
https://doaj.org/article/2fbcff291b1f4b25a493701f37d86ed8
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1639 (2021)
The vitamin D3 structure consists of the A-ring, a linker originating from the B-ring, C-ring, D-ring, and side-chain moieties. Each unit has its unique role in expressing the biological activities of vitamin D3. Many efforts have been made to date t
Externí odkaz:
https://doaj.org/article/a15807f742d24082a14ed00150e7ff8a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8191 (2021)
The discovery of a large variety of functions of vitamin D3 and its metabolites has led to the design and synthesis of a vast amount of vitamin D3 analogues in order to increase the potency and reduce toxicity. The introduction of highly electronegat
Externí odkaz:
https://doaj.org/article/13788bdc0cae4bfaad49665344f4db98
Autor:
Hayato Nakagawa, Atsushi Kittaka, Yusuke Akagi, Shigeyuki Kurosaki, Sayuri Mototani, Lisa Asano, Aileen Mendoza, Yasushi Takemoto, Kenjiro Kotake, Yuki Hayata, Kazuo Nagasawa, Motonari Uesugi, Satoshi Kawamura, Fumihiro Kawagoe
Publikováno v:
Journal of Medicinal Chemistry. 64:5689-5709
Vitamin D3 metabolites inhibit the expression of lipogenic genes by impairing sterol regulatory element-binding protein (SREBP), a master transcription factor of lipogenesis, independent of their canonical activity through a vitamin D receptor (VDR).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6539da680f4c06f349688a342b53501a
https://doi.org/10.1021/acs.jmedchem.0c02179
https://doi.org/10.1021/acs.jmedchem.0c02179
Autor:
Kazunari, Takada, Yukino, Hagiwara, Moeka, Togashi, Atsushi, Kittaka, Fumihiro, Kawagoe, Motonari, Uesugi, Shoichi, Nishimoto-Kusunose, Tatsuya, Higashi
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 223
The complete understanding of the excretion of surplus 25-hydroxyvitamin Dlt;subgt;3lt;/subgt; [25(OH)Dlt;subgt;3lt;/subgt;] in humans remains to be accomplished. In our previous study, 24,25-dihydroxyvitamin Dlt;subgt;3lt;/subgt; [24,25(OH)lt;subgt;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c280d58a173cbf2d1dd78a8004ffcc60
https://pubmed.ncbi.nlm.nih.gov/35654380
https://pubmed.ncbi.nlm.nih.gov/35654380
Autor:
Kazunari Takada, Yukino Hagiwara, Moeka Togashi, Atsushi Kittaka, Fumihiro Kawagoe, Motonari Uesugi, Shoichi Nishimoto-Kusunose, Tatsuya Higashi
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53b1c8bd6649d7a06f20a16103a47cfa
https://doi.org/10.2139/ssrn.4019591
https://doi.org/10.2139/ssrn.4019591
Autor:
Akiko Nagata, Shadi Sedghi Masoud, Aileen Mendoza, Fumihiro Kawagoe, Kazuo Nagasawa, Kosuke Usuda, Yasushi Takemoto, Kenjiro Kotake, Lisa Asano, Motonari Uesugi, Yusuke Akagi, Atsushi Kittaka, Koji Yasui
Publikováno v:
ACS chemical biology. 14(12):2851-2858
Vitamin D3 metabolites are capable of controlling gene expression in mammalian cells through two independent pathways: vitamin D receptor (VDR) and sterol regulatory element-binding protein (SREBP) pathways. In the present study, we dissect the compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb4978efeb1730dddec3596b072af0e
http://hdl.handle.net/2433/252796
http://hdl.handle.net/2433/252796