Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Fumihiko Ushigome"'
Autor:
Aiji Miyashita, Ikumi Nakajo, Hajimu Kurumatani, Jun Miyakawa, Masanao Isono, Keiyu Oshida, Kiyonobu Okada, Yohei Miyamoto, Masaaki Doi, Fumihiko Ushigome, Keishi Oikawa, Masahiro Shimamura, Yoshitaka Mori
Publikováno v:
The Journal of Clinical Pharmacology. 57:524-535
The purpose of the present study was to evaluate the pharmacokinetics of beraprost sodium (BPS) and its active enantiomer, BPS-314d, in Japanese subjects with impaired kidney function. The plasma and urine concentrations of BPS and BPS-314d were meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc938758c7263f0ee4902d332b559fab
https://doi.org/10.1002/jcph.835
https://doi.org/10.1002/jcph.835
Autor:
Fumihiko Ushigome, James Keirns, Lisa C. Plumb, Robert Townsend, Takeshi Kadokura, Walter Krauwinkel, Kenneth C. Lasseter, Ronald A. Smulders, Wenhui Zhang
Publikováno v:
Clinical Drug Investigation. 33:489-496
Ipragliflozin (ASP1941), a potent selective sodium glucose co-transporter 2 inhibitor, is in development for the treatment of type 2 diabetes mellitus. Ipragliflozin is primarily eliminated via conjugation by the liver as five pharmacologically inact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dcc9be8bf4ebe5b13107096e050c140
https://doi.org/10.1007/s40261-013-0089-6
https://doi.org/10.1007/s40261-013-0089-6
Autor:
Virginie Kerbusch, Yutaka Takahashi, Hiroyuki Nemoto, Fumihiko Ushigome, Takafumi Iwatsubo, Aiji Miyashita, Shin Takusagawa, Takashi Usui, Qun Li
Publikováno v:
Molecular Pharmaceutics. 10:1783-1794
Mirabegron, a weak-basic compound, is a potent and selective β3-adrenoceptor agonist for the treatment of overactive bladder. Mirabegron extended release formulation shows dose-dependent oral bioavailability in humans, which is likely attributable t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a98dd740c50d53eaeec7bea42176f7da
https://doi.org/10.1021/mp300582s
https://doi.org/10.1021/mp300582s
Autor:
Masahiro, Shimamura, Jun, Miyakawa, Masaaki, Doi, Kiyonobu, Okada, Hajimu, Kurumatani, Yoshitaka, Mori, Keiyu, Oshida, Ikumi, Nakajo, Keishi, Oikawa, Fumihiko, Ushigome, Aiji, Miyashita, Masanao, Isono, Yohei, Miyamoto
Publikováno v:
Journal of clinical pharmacology. 57(4)
The purpose of the present study was to evaluate the pharmacokinetics of beraprost sodium (BPS) and its active enantiomer, BPS-314d, in Japanese subjects with impaired kidney function. The plasma and urine concentrations of BPS and BPS-314d were meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c21937b196e4ca9dfc769ce9eb6c446
https://pubmed.ncbi.nlm.nih.gov/27681484
https://pubmed.ncbi.nlm.nih.gov/27681484
Autor:
Hiroki Satoh, Hisakazu Ohtani, Takeshi Uchiumi, Fumiaki Yamashita, Noriko Koyabu, Michihiko Kuwano, Takanori Nakamura, Fumihiko Ushigome, Masayuki Tsujimoto, Hideyasu Murakami, Yasufumi Sawada
Publikováno v:
Journal of Pharmacy and Pharmacology. 58:1499-1505
Human organic anion transporter 4 (OAT4) is the only member of the OAT family that is expressed in the placenta and also expressed in kidney. Although OAT4 has been shown to transport certain organic anions as well as other members of the OAT family,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6610d531e9d0150b8e739a07601284cc
https://doi.org/10.1211/jpp.58.11.0011
https://doi.org/10.1211/jpp.58.11.0011
Autor:
Takeshi Uchiumi, Yukihiro Shoyama, Michihiko Kuwano, Yoko Honda, Fumihiko Ushigome, Satoshi Morimoto, Yasufumi Sawada, Noriko Koyabu, Hisakazu Ohtani
Publikováno v:
British Journal of Pharmacology. 143:856-864
We investigated the effects of grapefruit juice (GFJ) and orange juice (OJ) on drug transport by MDR1 P-glycoprotein (P-gp) and multidrug resistance protein 2 (MRP2), which are efflux transporters expressed in human small intestine. We examined the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bd41284efb54959616b3cce42760f13
https://doi.org/10.1038/sj.bjp.0706008
https://doi.org/10.1038/sj.bjp.0706008
Autor:
Noriko Koyabu, Kiyomi Tsukimori, Michihiko Kuwano, Takanori Nakamura, Yasufumi Sawada, Hitoo Nakano, Takeshi Uchiumi, Fumihiko Ushigome, Hisakazu Ohtani, Shoji Satoh
Publikováno v:
Pharmaceutical Research. 20:38-44
Purpose. P-Glycoprotein (Pgp) plays an important role in drug disposition and excretion in various tissues such as the brain, intestine, and kidney. Moreover, we have demonstrated that Pgp is expressed on the brush-border membranes of trophoblast cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5f578813b490bedec7850e7cf39c699
https://doi.org/10.1023/a:1022290523347
https://doi.org/10.1023/a:1022290523347
Autor:
Akiko Emoto, Kiyomi Tsukimori, Masako Inuyama, Noriko Koyabu, Hisakazu Ohtani, Shoji Satoh, Fumihiko Ushigome, Yasufumi Sawada, Hitoo Nakano
Publikováno v:
American Journal of Physiology-Cell Physiology. 283:C822-C830
The characteristics of l-lactic acid transport across the trophoblast basal membrane were investigated and compared with those across the brush-border membrane by using membrane vesicles isolated from human placenta. The uptake ofl-[14C]lactic acid i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89600627c653eb6a42a261cb57f2fbd5
https://doi.org/10.1152/ajpcell.00545.2001
https://doi.org/10.1152/ajpcell.00545.2001
Autor:
Hiroaki Nakamura, Hitoo Nakano, Kiyomi Tsukimori, Noriko Koyabu, Hisakazu Ohtani, Shoji Satoh, Fumihiko Ushigome, Yasufumi Sawada
Publikováno v:
Pharmaceutical Research. 19:154-161
Purpose. To investigate the transport mechanism of valproic acid across the human placenta, we used human placental brush-border membrane vesicles and compared them with that of lactic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d307509ea15fe9ffb6df7c7bc6e5a9ff
https://doi.org/10.1023/a:1014242931475
https://doi.org/10.1023/a:1014242931475
Autor:
Shin, Takusagawa, Fumihiko, Ushigome, Hiroyuki, Nemoto, Yutaka, Takahashi, Qun, Li, Virginie, Kerbusch, Aiji, Miyashita, Takafumi, Iwatsubo, Takashi, Usui
Publikováno v:
Molecular pharmaceutics. 10(5)
Mirabegron, a weak-basic compound, is a potent and selective β3-adrenoceptor agonist for the treatment of overactive bladder. Mirabegron extended release formulation shows dose-dependent oral bioavailability in humans, which is likely attributable t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1285a218200d4a9b21f1b7c07dde5bce
https://pubmed.ncbi.nlm.nih.gov/23560393
https://pubmed.ncbi.nlm.nih.gov/23560393