Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Fumihiko Sagawa"'
Autor:
Satoshi Kozawa, Fumihiko Sagawa, Satsuki Endo, Glicia Maria De Almeida, Yuto Mitsuishi, Thomas N. Sato
Publikováno v:
iScience, Vol 23, Iss 2, Pp - (2020)
Summary: Approximately 90% of pre-clinically validated drugs fail in clinical trials owing to unanticipated clinical outcomes, costing over several hundred million US dollars per drug. Despite such critical importance, translating pre-clinical data t
Externí odkaz:
https://doaj.org/article/5d2853513a3640dcb97baad0b08fde0d
Autor:
Satoshi Kozawa, Ryosuke Ueda, Kyoji Urayama, Fumihiko Sagawa, Satsuki Endo, Kazuhiro Shiizaki, Hiroshi Kurosu, Glicia Maria de Almeida, Sharif M. Hasan, Kiyokazu Nakazato, Shinji Ozaki, Yoshinori Yamashita, Makoto Kuro-o, Thomas N. Sato
Publikováno v:
iScience, Vol 2, Iss , Pp 238-268 (2018)
Summary: Virtually all diseases affect multiple organs. However, our knowledge of the body-wide effects remains limited. Here, we report the body-wide transcriptome landscape across 13–23 organs of mouse models of myocardial infarction, diabetes, k
Externí odkaz:
https://doaj.org/article/40d692930b7c4ec6be5e8d98e5c5efff
Autor:
Norio Takada, Madoka Omae, Fumihiko Sagawa, Neil C. Chi, Satsuki Endo, Satoshi Kozawa, Thomas N. Sato
Publikováno v:
Biology Open, Vol 6, Iss 11, Pp 1756-1770 (2017)
The cardiovascular system facilitates body-wide distribution of oxygen, a vital process for the development and survival of virtually all vertebrates. However, the zebrafish, a vertebrate model organism, appears to form organs and survive mid-larval
Externí odkaz:
https://doaj.org/article/3be09c9923764ae6a5e88ac7913ce082
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120576 (2015)
An affinity resin-based pull-down method is convenient for the purification of biochemical materials. However, its use is difficult for the isolation of a molecular complex fully loaded with multiple components from a reaction mixture containing the
Externí odkaz:
https://doaj.org/article/2a3d290257c8490e9e436d5234814eb2
Autor:
Hajime Watanobe, Tomoyuki Furutani, Masahiko Nihei, Yu Sakuma, Rie Yanai, Miyuki Takahashi, Hideo Sato, Fumihiko Sagawa
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133345 (2015)
Externí odkaz:
https://doaj.org/article/a72603dfa38447f09e21ffc39b5968f5
Autor:
Hajime Watanobe, Tomoyuki Furutani, Masahiko Nihei, Yu Sakuma, Rie Yanai, Miyuki Takahashi, Hideo Sato, Fumihiko Sagawa
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113804 (2014)
BACKGROUND: A possible increase in thyroid cancer in the young represents the most critical health problem to be considered after the nuclear accident in Fukushima, Japan (March 2011), which is an important lesson from the Chernobyl disaster (April 1
Externí odkaz:
https://doaj.org/article/ba2089abc1a646728d64b40dff751eb3
Autor:
Doug E Brackney, Jaclyn C Scott, Fumihiko Sagawa, Jimmy E Woodward, Neil A Miller, Faye D Schilkey, Joann Mudge, Jeffrey Wilusz, Ken E Olson, Carol D Blair, Gregory D Ebel
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 10, p e856 (2010)
Mosquitoes rely on RNA interference (RNAi) as their primary defense against viral infections. To this end, the combination of RNAi and invertebrate cell culture systems has become an invaluable tool in studying virus-vector interactions. Nevertheless
Externí odkaz:
https://doaj.org/article/9148a471460d481b8aa476f504b8eb70
Autor:
Makoto Kuro-o, Ryosuke Ueda, Glicia Maria de Almeida, Kyoji Urayama, Satsuki Endo, Satoshi Kozawa, Shinji Ozaki, Fumihiko Sagawa, Kazuhiro Shiizaki, Yoshinori Yamashita, Hiroshi Kurosu, Sharif Hasan, Thomas N. Sato, Kiyokazu Nakazato
Publikováno v:
iScience, Vol 2, Iss, Pp 238-268 (2018)
Summary: Virtually all diseases affect multiple organs. However, our knowledge of the body-wide effects remains limited. Here, we report the body-wide transcriptome landscape across 13–23 organs of mouse models of myocardial infarction, diabetes, k
Autor:
Satsuki Endo, Satoshi Kozawa, Fumihiko Sagawa, Yuto Mitsuishi, Thomas N. Sato, Glicia Maria de Almeida
Publikováno v:
iScience
iScience, Vol 23, Iss 2, Pp-(2020)
iScience, Vol 23, Iss 2, Pp-(2020)
Summary Approximately 90% of pre-clinically validated drugs fail in clinical trials owing to unanticipated clinical outcomes, costing over several hundred million US dollars per drug. Despite such critical importance, translating pre-clinical data to
Publikováno v:
Biochemical and Biophysical Research Communications. 466:388-392
RNA-protein complexes (RNPs) are useful for constructing functional nano-objects because a variety of functional proteins can be displayed on a designed RNA scaffold. Here, we report circular permutations of an RNA-binding protein L7Ae based on the t