Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Fumihiko Okumura"'
Autor:
Fumihiko Okumura, Nodoka Oki, Yuha Fujiki, Rio Ikuta, Kana Osaki, Shun Hamada, Kunio Nakatsukasa, Naoki Hisamoto, Taichi Hara, Takumi Kamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Cell adhesion molecule-related/downregulated by oncogenes (Cdon) is a cell-surface receptor that mediates cell–cell interactions and positively regulates myogenesis. The cytoplasmic region of Cdon interacts with other proteins to form a Cd
Externí odkaz:
https://doaj.org/article/08aee543a91e44a5b0ff743fe54971e3
Autor:
Kino Kusama, Yuta Suzuki, Ena Kurita, Tomoyuki Kawarasaki, Keisuke Obara, Fumihiko Okumura, Takumi Kamura, Kunio Nakatsukasa
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103986- (2022)
Summary: Ribosome biogenesis (Ribi) is a complex and energy-consuming process, and should therefore be repressed under nutrient-limited conditions to minimize unnecessary cellular energy consumption. In yeast, the transcriptional repressors Dot6 and
Externí odkaz:
https://doaj.org/article/73516da92bbb46f0aced6d2241595953
Autor:
Hisashi Tanaka, Chiori Tabe, Fumihiko Okumura, Toshihiro Shiratori, Yoshiko Ishioka, Masamichi Itoga, Kageaki Taima, Takeshi Morimoto, Daisuke Kimura, Takao Tsushima, Sadatomo Tasaka
Publikováno v:
Thoracic Cancer, Vol 11, Iss 6, Pp 1633-1638 (2020)
Abstract Background Adjuvant chemotherapy with platinum‐based regimens for completely resected early‐stage non‐small cell lung cancer (NSCLC) provides overall survival benefit in several clinical trials. Objectives We conducted this prospective
Externí odkaz:
https://doaj.org/article/a8a0dc620a0448d4914551e50fca6df8
Autor:
Masaki Dobashi, Hisashi Tanaka, Kageaki Taima, Masamichi Itoga, Yoshiko Ishioka, Toshihiro Shiratori, Fumihiko Okumura, Chiori Tabe, Yoshihito Tanaka, Takeshi Morimoto, Yukihiro Hasegawa, Hideo Yasugahira, Koichi Okudera, Shingo Takanashi, Sadatomo Tasaka
Publikováno v:
SAGE Open Medicine, Vol 9 (2021)
Background: The INPULSIS trials revealed that nintedanib reduced the decline in lung function in patients with idiopathic pulmonary fibrosis. We aimed to evaluate the efficacy and safety of nintedanib in Japanese idiopathic pulmonary fibrosis patient
Externí odkaz:
https://doaj.org/article/757362f920d74ab8a1a0332ab2961ec5
Autor:
Fumihiko Okumura, Yuha Fujiki, Nodoka Oki, Kana Osaki, Akihiko Nishikimi, Yoshinori Fukui, Kunio Nakatsukasa, Takumi Kamura
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: The UGA codon signals protein translation termination, but it can also be translated into selenocysteine (Sec, U) to produce selenocysteine-containing proteins (selenoproteins) by dedicated machinery. As Sec incorporation can fail, Sec-conta
Externí odkaz:
https://doaj.org/article/212577d80af34fa5b2149179536bfa85
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175593 (2017)
Ubiquitin ligase von Hippel-Lindau tumor suppressor (pVHL) negatively regulates protein levels of hypoxia-inducible factor-α (HIF-α). Loss of pVHL causes HIF-α accumulation, which contributes to the pathogenesis of von Hippel-Lindau (VHL) disease.
Externí odkaz:
https://doaj.org/article/1277e6a3380e4f9990952f4d5f306873
Autor:
Yume Nakamura, Fumihiko Okumura, Mayumi Nihei, Kei Chubachi, Hiroaki Sakamoto, Yoshiko Ishioka, Tomonori Makiguchi, Hisashi Tanaka, Kageaki Taima, Nobuhisa Yajima, Akira Kurose, Sadatomo Tasaka
Publikováno v:
Internal Medicine. 62:589-593
Autor:
Nodoka Oki, Shino Yamada, Tamaki Tanaka, Hiromi Fukui, Shigetsugu Hatakeyama, Fumihiko Okumura
Publikováno v:
Biochemical and Biophysical Research Communications. 625:94-101
The expression of the ubiquitin-like molecule interferon-stimulated gene 15 kDa (ISG15) and post-translational protein modification by ISG15 (ISGylation) are strongly activated by interferons or pathogen infection, suggesting that ISG15 and ISGylatio
Autor:
Kunio Nakatsukasa, Munetaka Fujisawa, Xiaotan Yang, Tomoyuki Kawarasaki, Fumihiko Okumura, Takumi Kamura
Publikováno v:
Biochemical and Biophysical Research Communications. 626:85-91
Triacylglycerols (TGs) serve as reservoirs for diacylglycerols and fatty acids, which play important roles in synthesizing energy and membrane lipids that are required for cell cycle progression. In the yeast, Saccharomyces cerevisiae, Tgl4, the func
Autor:
Kazuya Nishio, Tomoyuki Kawarasaki, Yuki Sugiura, Shunsuke Matsumoto, Ayano Konoshima, Yuki Takano, Mayuko Hayashi, Fumihiko Okumura, Takumi Kamura, Tsunehiro Mizushima, Kunio Nakatsukasa
Publikováno v:
Science Advances. 9
Deficiencies in mitochondrial protein import are associated with a number of diseases. However, although nonimported mitochondrial proteins are at great risk of aggregation, it remains largely unclear how their accumulation causes cell dysfunction. H