Výsledky vyhledávání - "Fumihiko Kanzawa"

In vitro effects of combinations of cis-amminedichloro (2-methylpyridine) platinum (II) (ZD0473) with other novel anticancer drugs on the growth of SBC-3, a human small cell lung cancer cell line

Autor: Nagahiro Saijo, Yoshiko Akiyama, Fumihiko Kanzawa, Kazuto Nishio

Publikováno v: Lung Cancer. 40:325-332

Among numerous clinical regimens of combination chemotherapy, synergy has been observed to be particularly marked with combinations containing cisplatin (CDDP). However, the clinical use of CDDP has sometimes been limited by acquired resistance. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e95fec62288d3d0d6d9899704267d5
https://doi.org/10.1016/s0169-5002(03)00072-2

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Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib (?Iressa?) and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells

Autor: Shoji Tsukiyama, Fumiaki Koizumi, Yutaka Ueda, Kazuto Nishio, Tomohide Tamura, Yasuhiro Koh, Fumiko Taguchi, Nagahiro Saijo, Fumihiko Kanzawa

Publikováno v: International Journal of Cancer. 108:464-472

Epidermal growth factor receptor [EGFR (HER1, erbB1)] is a receptor with associated tyrosine kinase activity, and is expressed in colorectal cancers and many other solid tumors. We examined the effect of the selective EGFR tyrosine kinase inhibitor (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24410594f7056d15c2b7705e0155c497
https://doi.org/10.1002/ijc.11539

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Non-cross resistance of ZD0473 in acquired cisplatin-resistant lung cancer cell lines

Autor: Fumihiko Kanzawa, Yoshiko Kawamura-Akiyama, Nagahiro Saijo, Kazuto Nishio, Tomohide Tamura, H Kusaba

Publikováno v: Lung Cancer. 38:43-50

ZD0473 is a new generation platinum agent that, in preclinical studies, shows evidence of an extended spectrum of anti-tumor activity and overcomes platinum resistance mechanisms. The drug contains a bulky methylpyridine ligand at its platinum center

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a89db14e2482323fbf901c4a9d2cd5
https://doi.org/10.1016/s0169-5002(02)00175-7

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Mechanism of vinorelbine-induced radiosensitization of human small cell lung cancer cells

Autor: Hirokazu Kurokawa, Toshihiro Suzuki, Nagahiro Saijo, Hisao Fukumoto, Jitsuo Usuda, Tomoyuki Ishida, Kazuya Fukuoka, Yasuo Iwamoto, Akira Tomonari, Kazuto Nishio, Hiroshi Kimura, Fumihiko Kanzawa, Hitoshi Arioka

Publikováno v: Cancer Chemotherapy and Pharmacology. 49:385-390

Vinorelbine (Navelbine, KW-2307), a semisynthetic vinca alkaloid, is a potent inhibitor of mitotic microtubule polymerization. The aims of this study were to demonstrate vinorelbine-induced radiosensitization of human small cell lung cancer (SCLC) SB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f00fd8c5313a4663929610cdd1753ab
https://doi.org/10.1007/s00280-002-0430-x

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Pierisin-1 from cabbage butterfly suppresses HeLa tumor growth in nude mice

Autor: Takashi Sugimura, Takashi Kanazawa, Noriaki Tanaka, Kotaro Koyama, Fumihiko Kanzawa, Keiji Wakabayashi, Masahiko Watanabe, Yuko Matsushima-Hibiya

Publikováno v: Proceedings of the Japan Academy, Series B. 78:305-308

Pierisin-1 is a 98kDa protein known to induce apoptosis in various human carcinoma cell lines with a very wide range of IC50 values. Among those, the cervical carcinoma HeLa cells are the most sensitive, showing IC50 value of 0.043ng/ml. In the prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc40f7857a9d4efebb9532c75dc7b80b
https://doi.org/10.2183/pjab.78.305

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Mechanism of the radiosensitization induced by vinorelbine in human non-small cell lung cancer cells

Autor: Akira Tomonari, Tomoyuki Ishida, Fumihiko Kanzawa, Jitsuo Usuda, Hirokazu Kurokawa, Hitoshi Arioka, Toshihiro Suzuki, Hisao Fukumoto, Kazuya Fukuoka, Yasuo Iwamoto, Kazuto Nishio, Nagahiro Saijo

Publikováno v: Lung Cancer. 34:451-460

Vinorelbine (Navelbine, KW-2307), a semisynthetic vinca alkaloid, is a potent inhibitor of mitotic microtubule polymerization. The aims of this study were to demonstrate radiosensitization produced by vinorelbine in human non-small cell lung cancer (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88bffebd529c06fbd491e38f0289d86
https://doi.org/10.1016/s0169-5002(01)00265-3

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Oncoprotein 18 overexpression increases the sensitivity to vindesine in the human lung carcinoma cells

Autor: Nagahiro Saijo, Takashi Nakamura, Tomohide Tamura, Yasuhiro Koh, Fumihiko Kanzawa, Kazuto Nishio

Publikováno v: Cancer. 91:1494-1499

BACKGROUND Oncoprotein 18 (op18) was first isolated as a molecule overexpressed in several malignant cells, suggesting a function of op18 in malignant processes, such as differentiation in hematologic malignancies, op18 also was found to enhance micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33197ed675125714722110a3f6176926
https://doi.org/10.1002/1097-0142(20010415)91:8<1494::aid-cncr1157>3.0.co

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Combination effects of TAS-103, a novel dual topoisomerase I and II inhibitor, with other anticancer agents on human small cell lung cancer cells

Autor: Nagahiro Saijo, Toshihiko Sunami, Jyunichi Yoshikawa, Kazuya Fukuoka, Kazuto Nishio, Shinzo Kudoh, Fumihiko Kanzawa

Publikováno v: Cancer Chemotherapy and Pharmacology. 43:394-401

Purpose: TAS-103 [6-((2-(dimethylamino) ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride] is a newly synthesized dual inhibitor of topoisomerase I and II. Since anticancer drugs are used in combination with other drugs for effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449e80799bea7918eeefb90e0aa63ee2
https://doi.org/10.1007/s002800050913

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Evaluation of synergism by a novel three-dimensional model for the combined action of cisplatin and etoposide on the growth of a human small-cell lung-cancer cell line, SBC-3

Autor: Kazuto Nishio, Nagahiro Saijo, Takehiko Kunimoto, Fumihiko Kanzawa, Minoru Fukuda, Kazuya Fukuoka

Publikováno v: International Journal of Cancer. 71:311-319

Although the combination of cisplatin and etoposide has been used as standard therapy for small-cell lung cancer, it is difficult to demonstrate combination effects between cisplatin and etoposide in vitro. We therefore adopted a 3-dimensional (3-D)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aae635ced19a3df07c9dce8ef4efe7b
https://doi.org/10.1002/(sici)1097-0215(19970502)71:3<311::aid-ijc1>3.0.co

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Anti-tumour activities of a new benzo[c]phenanthridine agent, 2,3-(methylenedioxy)-5-methyl-7-hydroxy-8-methoxybenzo[c]phena nthridini um hydrogensulphate dihydrate (NK109), against several drug-resistant human tumour cell lines

Autor: Hirokazu Kurokawa, K. Bojanowski, H Fukumoto, Minoru Fukuda, Nagahiro Saijo, K Fukuoka, Kazuto Nishio, Y Nomoto, Fumihiko Kanzawa, Takanori Ishida

Publikováno v: British Journal of Cancer

Drug resistance is one of the problems severely limiting chemotherapy in cancer patients. Thus, it is very important to develop new drugs that are effective against drug-resistant tumour cells. The novel anti-tumour agent NK109 has been developed fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9c5b6fb542a1f053a945b93c4aaac3
http://europepmc.org/articles/PMC2228004

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