Výsledky vyhledávání - "Fumihiko Iino"

Pyridonecarboxylic Acids as Antibacterial Agents. VI. Synthesis and Structure-Activity Relationship of 7-(Alkyl, Cycloalkyl, and Vinyl)-1-cyclopropyl-6-fluoro-4-quinolone-3-carboxylic Acids

Autor: Hirokazu Narita, Yoshikazu Fukuoka, Saikawa Isamu, Hiroyasu Takag, Yozo Todo, Fumihiko Iino, Keiichi Tanaka, Yasushi Ikeda

Publikováno v: Chemical and Pharmaceutical Bulletin. 42:2049-2054

The title compounds (1a-i) have been synthesized starting with ethyl 1-cyclopropyl-6, 7-difluoro-4-quinolone-3-carboxylate (2). The 7-cyclopropyl and 7-vinyl derivatives (1e and 1i) exhibited potent in vitro antibacterial activities against both gram

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c278dee29d6865eecf5c50174ec044
https://doi.org/10.1248/cpb.42.2049

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Pyridonecarboxylic Acids as Antibacterial Agents. IX. Synthesis and Structure-Activity Relationship of 3-Substituted 10-(1-Aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic Acids and Their 1-Thio and 1-Aza Analogues

Autor: Yozo Todo, Seiki Okamoto, Hiroyasu Takagi, Saikawa Isamu, Fumihiko Iino, Yoshikazu Fukuoka, Masahiro Takahata, Hirokazu Narita

Publikováno v: Chemical and Pharmaceutical Bulletin. 42:2569-2574

A series of the title compounds listed in Chart 1 have been synthesized to study the effects of 3-alkyl substituents on the antibacterial potency and in vivo efficacy of 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2, 3-dihydro-7H-pyrido[1, 2, 3-de]-1, 4-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67df4520fb02bc3a5a6830d93f6a6f19
https://doi.org/10.1248/cpb.42.2569

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