Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Fumihiko Hayakawa"'
Autor:
Chiharu Yamada, Kentaro Okada, Koya Odaira, Mahiru Tokoro, Eisuke Iwamoto, Masashi Sanada, Mina Noura, Syuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa
Publikováno v:
Cancer Medicine, Vol 13, Iss 14, Pp n/a-n/a (2024)
Abstract Background ZNF384‐fusion (Z‐fusion) genes were recently identified in B‐cell acute lymphoblastic leukemia (B‐ALL) and are frequent in Japanese adult patients. The frequency is about 20% in those with Philadelphia chromosome‐negativ
Externí odkaz:
https://doaj.org/article/b55bd970f1ed4ff483e308ce00e8478f
Autor:
Mina Noura, Sakura Tomita, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa
Publikováno v:
Cancer Medicine, Vol 13, Iss 13, Pp n/a-n/a (2024)
Abstract Introduction Nucleoporin 98 (NUP98) fusion proteins are recurrently found in leukemia and are associated with unfavorable clinical outcomes. They are distributed to the nucleus and contribute to leukemogenesis via aberrant transcriptional re
Externí odkaz:
https://doaj.org/article/62eef3402d8c4ee5810cff35ce56134f
Autor:
Shinobu Tsuzuki, Takahiko Yasuda, Hiroaki Goto, Naoko Maeda, Koshi Akahane, Takeshi Inukai, Hideyuki Yamamoto, Sivasundaram Karnan, Akinobu Ota, Toshinori Hyodo, Hiroyuki Konishi, Yoshitaka Hosokawa, Hitoshi Kiyoi, Fumihiko Hayakawa
Publikováno v:
Haematologica, Vol 108, Iss 2 (2022)
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is an intractable disease and most cases harbor genetic alterations that activate JAK or ABL signaling. The commonest subtype of Ph-like ALL exhibits a CRLF2 gene rearrangement t
Externí odkaz:
https://doaj.org/article/514652542c624b93836c399d9da87c53
Autor:
Chisato Inoue, Sayaka Sobue, Yuka Aoyama, Naoki Mizutani, Yoshiyuki Kawamoto, Yuji Nishizawa, Masatoshi Ichihara, Akihiro Abe, Fumihiko Hayakawa, Motoshi Suzuki, Yoshinori Nozawa, Takashi Murate
Publikováno v:
Biochemistry and Biophysics Reports, Vol 15, Iss , Pp 69-75 (2018)
Imatinib (IMT), a specific tyrosine kinase inhibitor (TKI), has drastically changed the treatment strategy for Ph+ ALL (Philadelphia chromosome-positive acute lymphoblastic leukemia). However, TKI resistance remains a serious problem for patient prog
Externí odkaz:
https://doaj.org/article/9342885dd363411bb3e3a41e3633a551
Autor:
Mahiru Tokoro, Shogo Tamura, Nobuaki Suzuki, Misaki Kakihara, Yuna Hattori, Koya Odaira, Sachiko Suzuki, Akira Takagi, Akira Katsumi, Fumihiko Hayakawa, Shuichi Okamoto, Atsuo Suzuki, Takeshi Kanematsu, Tadashi Matsushita, Tetsuhito Kojima
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 9, Pp n/a-n/a (2020)
Abstract Background Hemophilia A (HA) is an X‐linked recessive bleeding disorder caused by pathogenic variants of the coagulation factor VIII gene (F8). Half of the patients with severe HA have a recurrent inversion in the X chromosome, that is, F8
Externí odkaz:
https://doaj.org/article/c36a585e4f024cb4b01c8505cea70a62
Autor:
Naoyuki Tange, Fumihiko Hayakawa, Takahiko Yasuda, Koya Odaira, Hideyuki Yamamoto, Daiki Hirano, Toshiyasu Sakai, Seitaro Terakura, Shinobu Tsuzuki, Hitoshi Kiyoi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 128, Iss , Pp 110330- (2020)
MEF2D-fusion (M-fusion) genes are newly discovered recurrent gene abnormalities that are detected in approximately 5 % of acute lymphoblastic leukemia (ALL) cases. Their introduction to cells has been reported to transform cell lines or increase the
Externí odkaz:
https://doaj.org/article/63e254a40fcc4088962ec117b8ca8050
Autor:
Yosuke Tanaka, Masahito Kawazu, Takahiko Yasuda, Miki Tamura, Fumihiko Hayakawa, Shinya Kojima, Toshihide Ueno, Hitoshi Kiyoi, Tomoki Naoe, Hiroyuki Mano
Publikováno v:
Haematologica, Vol 103, Iss 11 (2018)
Externí odkaz:
https://doaj.org/article/4e202f4747bf4d419a9feb1e21408a92
Autor:
Daisuke Koyama, Makoto Murata, Ryo Hanajiri, Shingo Okuno, Sonoko Kamoshita, Jakrawadee Julamanee, Erina Takagi, Daiki Hirano, Kotaro Miyao, Reona Sakemura, Tatsunori Goto, Fumihiko Hayakawa, Aika Seto, Yukiyasu Ozawa, Koichi Miyamura, Seitaro Terakura, Tetsuya Nishida, Hitoshi Kiyoi
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185213 (2017)
Regenerating islet-derived protein 3 alpha (REG3A) is a biomarker of lower gastrointestinal graft-versus-host disease (GVHD); however, the biological role of REG3A in the pathophysiology of GVHD is not understood. Here, we examined the association be
Externí odkaz:
https://doaj.org/article/e238b7407fde42068b4d12ef57c9b8c6
Publikováno v:
Cancer Science. 114:8-15
B-cell acute lymphoblastic leukemia (B-ALL), a genetically heterogeneous disease, is classified into different molecular subtypes that are defined by recurrent gene rearrangements, gross chromosomal abnormalities, or specific gene mutations. Cells wi
Autor:
Shuichi Okamoto, Shogo Tamura, Naomi Sanda, Koya Odaira, Yuri Hayakawa, Masato Mukaide, Atsuo Suzuki, Takeshi Kanematsu, Fumihiko Hayakawa, Akira Katsumi, Hitoshi Kiyoi, Tetsuhito Kojima, Tadashi Matsushita, Nobuaki Suzuki
Publikováno v:
Journal of Thrombosis and Haemostasis. 20(8):1784-1796
Background: Von Willebrand factor (VWF) is a multimeric glycoprotein that plays important roles in hemostasis and thrombosis. C-terminal interchain-disulfide bonds in the cystine knot (CK) domain are essential for VWF dimerization. Previous studies h