Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Fumihiko, Hakuno"'
Autor:
Ryosuke Okino, Kazuaki Mukai, Shunpei Oguri, Masato Masuda, Satoshi Watanabe, Yosuke Yoneyama, Sumine Nagaosa, Takafumi Miyamoto, Atsushi Mochizuki, Shin-Ichiro Takahashi, Fumihiko Hakuno
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Insulin-like growth factor (IGF)-I mediates long-term activities that determine cell fate, including cell proliferation and differentiation. This study aimed to characterize the mechanisms by which IGF-I determines cell fate from the aspect
Externí odkaz:
https://doaj.org/article/f335554470cf42a8b27eadce2a4e7260
Autor:
Hiroki Nishi, Yuki Goda, Ryosuke Okino, Ruri Iwai, Reona Maezawa, Koichi Ito, Shin-Ichiro Takahashi, Daisuke Yamanaka, Fumihiko Hakuno
Publikováno v:
Current Developments in Nutrition, Vol 8, Iss 6, Pp 103768- (2024)
Background: It is generally accepted that excessive fat intake has undesirable effects on the energy metabolism of our body. Dietary amino acid composition is also critical to the regulation of lipid metabolism. Objectives: This study aimed to invest
Externí odkaz:
https://doaj.org/article/2538e953a4c14377934c577190c00455
Autor:
Keitaro Yamanouchi, Yukie Tanaka, Masanari Ikeda, Shizuka Kato, Ryosuke Okino, Hiroki Nishi, Fumihiko Hakuno, Shin-Ichiro Takahashi, James Chambers, Takashi Matsuwaki, Kazuyuki Uchida
Publikováno v:
Skeletal Muscle, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Background Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by a complete lack of dystrophin, which stabilizes the plasma membrane of myofibers. The orofacial function is affected in an advanced stage of DMD and this of
Externí odkaz:
https://doaj.org/article/aeae3a048a30439680dbbe41dd4509b4
Autor:
Takahisa Matsuzaki, Yuma Kawano, Momoka Horikiri, Yuko Shimokawa, Takashi Yamazaki, Nao Okuma, Hiroyuki Koike, Masaki Kimura, Ryuzo Kawamura, Yosuke Yoneyama, Yasuro Furuichi, Fumihiko Hakuno, Shin-Ichiro Takahashi, Seiichiro Nakabayashi, Satoshi Okamoto, Hiromitsu Nakauchi, Hideki Taniguchi, Takanori Takebe, Hiroshi Y. Yoshikawa
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102471- (2023)
Summary: Synthetic protocols providing mechanical patterns to culture substrate are essential to control the self-condensation of cells for organoid engineering. Here, we present a protocol for preparing hydrogels with mechanical patterns. We describ
Externí odkaz:
https://doaj.org/article/5ac5fb67f0014012992e77792fc35a70
Autor:
Ayaka Zasu, Futa Hishima, Marion Thauvin, Yosuke Yoneyama, Yoichiro Kitani, Fumihiko Hakuno, Michel Volovitch, Shin-Ichiro Takahashi, Sophie Vriz, Christine Rampon, Hiroyasu Kamei
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Oxygen deprivation induces multiple changes at the cellular and organismal levels, and its re-supply also brings another special physiological status. We have investigated the effects of hypoxia/re-oxygenation on embryonic growth using the zebrafish
Externí odkaz:
https://doaj.org/article/f0ee5695ed124376b2d98b31bf6d316f
Autor:
Mimin Zhang, Peng Lu, Tohru Terada, Miaomiao Sui, Haruka Furuta, Kilico Iida, Yukie Katayama, Yi Lu, Ken Okamoto, Michio Suzuki, Tomiko Asakura, Kentaro Shimizu, Fumihiko Hakuno, Shin-Ichiro Takahashi, Norimoto Shimada, Jinwei Yang, Tsutomu Ishikawa, Jin Tatsuzaki, Koji Nagata
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
A compound from Thai black ginger, KPMF-8, was previously found to dramatically promote activation of SIRT1 towards a peptide substrate. Zhang et al. now show that KPMF-8 can be taken up by cells through culture media, directly interacts with SIRT1,
Externí odkaz:
https://doaj.org/article/5a67ff013a7841da9cbb1ba0d1000592
Autor:
Hiroki Nishi, Daisuke Yamanaka, Masato Masuda, Yuki Goda, Koichi Ito, Fumihiko Hakuno, Shin-Ichiro Takahashi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Studies on animal models have demonstrated that feeding a low-arginine diet inhibits triacylglycerol (TAG) secretion from the liver, resulting in marked fatty liver development in rats. Here, we first showed that culturing hepatocytes in the
Externí odkaz:
https://doaj.org/article/da3c335dee9348e3be7270e3b497e1fa
Autor:
Lila Otani, Hiroki Nishi, Ayaka Koyama, Yuta Akasaka, Yusuke Taguchi, Yuka Toyoshima, Daisuke Yamanaka, Fumihiko Hakuno, Huijuan Jia, Shin-Ichiro Takahashi, Hisanori Kato
Publikováno v:
Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-13 (2020)
Abstract Background Dietary protein deficiency and amino acid imbalance cause hepatic fat accumulation. We previously demonstrated that only arginine deficiency or total amino acid deficiency in a diet caused significant hepatic triglyceride (TG) acc
Externí odkaz:
https://doaj.org/article/48b4e35b382d4f8bb1d22f277e9d5aad
Autor:
Takafumi Miyamoto, Hideki Uosaki, Yuhei Mizunoe, Song-Iee Han, Satoi Goto, Daisuke Yamanaka, Masato Masuda, Yosuke Yoneyama, Hideki Nakamura, Naoko Hattori, Yoshinori Takeuchi, Hiroshi Ohno, Motohiro Sekiya, Takashi Matsuzaka, Fumihiko Hakuno, Shin-Ichiro Takahashi, Naoya Yahagi, Koichi Ito, Hitoshi Shimano
Publikováno v:
Cell Reports: Methods, Vol 1, Iss 4, Pp 100052- (2021)
Summary: Engineered synthetic biomolecular devices that integrate elaborate information processing and precisely regulate living cell behavior have potential in various applications. Although devices that directly regulate key biomolecules constituti
Externí odkaz:
https://doaj.org/article/75ae182478b64fe69033777691d2582b
Autor:
Sara Fukushima, Hiroki Nishi, Mikako Kumano, Daisuke Yamanaka, Naoyuki Kataoka, Fumihiko Hakuno, Shin-Ichiro Takahashi
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102778- (2021)
Summary: Emerging evidence has shown that amino acids act as metabolic regulatory signals. Here, we showed that glucose-6-phosphatase (G6Pase) mRNA levels in cultured hepatocyte models were downregulated in an amino-acid-depleted medium. Inversely, s
Externí odkaz:
https://doaj.org/article/167435590a2f4a1ab737c562f3313d54