Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Fumie Takahashi"'
Autor:
Hidehiko Fukahori, Kaoru Yamagami, Satoshi Kubo, Yukihito Sugano, Fumie Takahashi, Ayako Moritomo, Koji Kato, Susumu Yamaki, Koji Nakamura, Koji Yokoo, Toshihiro Hamajima, Suzuki Daisuke
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:1056-1064
Chemical optimization of the 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (THPP) scaffold was conducted with a focus on cellular potency while maintaining high selectivity against PI3K isoforms. Compound 11f was identified as a potent, highly selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f4885a30545480350b0f2b6589425c
https://doi.org/10.1016/j.bmc.2019.02.001
https://doi.org/10.1016/j.bmc.2019.02.001
Autor:
Misato Ito, Kaoru Yamagami, Takanori Marui, Koji Kato, Tatsuaki Morokata, Tomoko Kawashima, Masahiko Akamatsu, Yoko Kaneko, Fumie Takahashi, Hidehiko Fukahori
Publikováno v:
International immunopharmacology. 87
Phosphoinositide 3-kinases generate lipid-based second messengers that control an array of intracellular signaling pathways. In particular, phosphoinositide 3-kinases delta (PI3Kδ) is expressed primarily in hematopoietic cells and plays an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb056144fe3be97720f2fc059c8967f
https://pubmed.ncbi.nlm.nih.gov/32736191
https://pubmed.ncbi.nlm.nih.gov/32736191
Autor:
Koichiro Mukoyoshi, Kaoru Yamagami, Kousei Yoshihara, Koji Yokoo, Susumu Yamaki, Fumie Takahashi, Toshihiro Hamajima, Yukihito Sugano, Koji Kato, Hidehiko Fukahori, Ayako Moritomo
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2410-2419
Phosphatidylinositol-3-kinase (PI3K)δ inhibition is one of the most attractive approaches to the treatment of autoimmune diseases and leukocyte malignancies. Through the exploration of pyrazolopyridine derivatives as potential PI3Kδ inhibitors, com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ec92c15654c1c5276396c3ef1540be
https://doi.org/10.1016/j.bmc.2018.03.042
https://doi.org/10.1016/j.bmc.2018.03.042
Autor:
Toshihiro Hamajima, Fumie Takahashi, Yukihito Sugano, Susumu Yamaki, Satoshi Kubo, Kaoru Yamagami, Koji Kato, Koji Nakamura, Nozomu Hamakawa, Koji Yokoo, Hidehiko Fukahori, Ayako Moritomo
Publikováno v:
Bioorganicmedicinal chemistry. 26(14)
Chemical optimization of pyrazolopyridine 1, focused on cellular potency, isoform selectivity and microsomal stability, led to the discovery of the potent, selective and orally available PI3Kδ inhibitor 5d. On the basis of its desirable potency, sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7780e6b0ae77807416e7f21ce49912f2
https://pubmed.ncbi.nlm.nih.gov/29907471
https://pubmed.ncbi.nlm.nih.gov/29907471
Autor:
Kazuo Nakai, Hiroyuki Usuda, Keiko Hatanaka, Hiroshi Sasaki, Ayako Moritomo, Shohei Shirakami, Yutaka Nakajima, Takayuki Inoue, Koichiro Mukoyoshi, Hisao Hamaguchi, Yasuyuki Higashi, Akira Tanaka, Masamichi Inami, Shigeki Kunikawa, Fumie Takahashi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:4871-4883
Janus kinases (JAKs) regulate various inflammatory and immune responses and are targets for the treatment of inflammatory and immune diseases. As a novel class of immunomodulators targeting JAK3, 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0d90a44fe1070af2ea6f03901725db
https://doi.org/10.1016/j.bmc.2015.05.034
https://doi.org/10.1016/j.bmc.2015.05.034
Autor:
Hiroaki Yamagishi, Shohei Shirakami, Akira Tanaka, Masamichi Inami, Takayuki Inoue, Ayako Moritomo, Yutaka Nakajima, Keiko Hatanaka, Fumie Takahashi, Hisao Hamaguchi, Yasuyuki Higashi
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:4846-4859
Because Janus kinases (JAKs) play a crucial role in cytokine-mediated signal transduction, JAKs are an attractive target for the treatment of organ transplant rejection and autoimmune diseases such as rheumatoid arthritis (RA). To identify JAK inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d3665766871cedaef06b4f21305117
https://doi.org/10.1016/j.bmc.2015.05.028
https://doi.org/10.1016/j.bmc.2015.05.028
Autor:
Hisao Hamaguchi, Yasuyuki Higashi, Akira Tanaka, Ayako Moritomo, Yutaka Nakajima, Masataka Morita, Takashi Tojo, Shohei Shirakami, Hiroshi Sasaki, Kazuo Nakai, Keiko Hatanaka, Fumie Takahashi, Koichiro Mukoyoshi, Takayuki Inoue
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 63:341-353
Janus kinases (JAKs) have been known to play crucial roles in modulating a number of inflammatory and immune mediators. Here, we describe a series of 1H-pyrrolo[2,3-b]pyridine derivatives as novel immunomodulators targeting JAK3 for use in treating i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46a152d038420cc6b471f5ce5284ea06
https://doi.org/10.1248/cpb.c15-00036
https://doi.org/10.1248/cpb.c15-00036
Autor:
Junichi Tanaka, Hitoshi Kuroda, Michiaki Abe, Tadashi Ishii, Yuka Ikeno, Soichiro Kaneko, Fumie Takahashi, Akiko Kikuchi, Nobuo Yaegashi, Masashi Watanabe, Hitoshi Nishikawa, Takehiro Numata, Takashi Takeda, Shin Takayama, Tetsuharu Kamiya, Ryutaro Arita, Hidekazu Watanabe, Natsumi Saito, Minoru Ohsawa, Seiichi Ishii
Publikováno v:
The Tohoku journal of experimental medicine. 240(2)
Traditional Japanese Kampo medicine has been widely used in clinical practice in Japan. Though it is a compulsory subject in Japanese medical schools, a standard educational program in Kampo medicine does not exist. Tohoku University has incorporated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2672a8ea58ff308a4d4234170fe708
https://pubmed.ncbi.nlm.nih.gov/27682223
https://pubmed.ncbi.nlm.nih.gov/27682223
Autor:
Takayuki Inoue, Hiroshi Sasaki, Fumie Takahashi, Fumihiro Nakamori, Masamichi Inami, Yutaka Nakajima, Misato Ito, Koji Nakamura, Naohiro Aoyama, Keiko Hatanaka, Shohei Shirakami, Ayako Moritomo
Publikováno v:
Bioorganicmedicinal chemistry. 24(19)
In organ transplantation, T cell-mediated immune responses play a key role in the rejection of allografts. Janus kinase 3 (JAK3) is specifically expressed in hematopoietic cells and associated with regulation of T cell development via interleukin-2 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01f9171ac1180536b424b8a3883c6e0
https://pubmed.ncbi.nlm.nih.gov/27544589
https://pubmed.ncbi.nlm.nih.gov/27544589
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 61:277-283
We identified four degradants (Dg-A, Dg-B, Dg-C, Dg-D) of azelnidipine to be generated under radical initiator-based oxidative conditions and proposed the mechanistic pathway for their formation. 2,2'-Azobisisobutyronitrile was used as a radical init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e004be0cb70e6c98e1025f8758e6505d
https://doi.org/10.1016/j.jpba.2011.12.001
https://doi.org/10.1016/j.jpba.2011.12.001