Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Fumiaki Koizumi"'
Autor:
Ryo Negishi, Hitomi Yamakawa, Takeru Kobayashi, Mayuko Horikawa, Tatsu Shimoyama, Fumiaki Koizumi, Takeshi Sawada, Keisuke Oboki, Yasushi Omuro, Chikako Funasaka, Akihiko Kageyama, Yusuke Kanemasa, Tsuyoshi Tanaka, Tadashi Matsunaga, Tomoko Yoshino
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Ryo Negishi et al. utilize a size-dependent recovery method with gel-based cell manipulation to isolate single circulating tumor cells (CTCs) for transcriptomic analysis. They demonstrate the utility of this approach by analyzing the transcriptomic p
Externí odkaz:
https://doaj.org/article/a86e30aadf1544eabe472e2a9f2ede17
Autor:
Takeshi Sawada, Jungo Araki, Toshinari Yamashita, Manami Masubuchi, Tsuneko Chiyoda, Mayu Yunokawa, Kumiko Hoshi, Shoichi Tao, Shohei Yamamura, Shouki Yatsushiro, Kaori Abe, Masatoshi Kataoka, Tatsu Shimoyama, Yoshiharu Maeda, Katsumasa Kuroi, Kenji Tamura, Tsuneo Sawazumi, Hironobu Minami, Yoshihiko Suda, Fumiaki Koizumi
Publikováno v:
EBioMedicine, Vol 11, Iss C, Pp 173-182 (2016)
Various types of circulating tumor cell (CTC) detection systems have recently been developed that show a high CTC detection rate. However, it is a big challenge to find a system that can provide better prognostic value than CellSearch in head-to-head
Externí odkaz:
https://doaj.org/article/efcb3e16cf3848fbbc82c246f3751419
Autor:
Atsushi Morimoto, Toshifumi Mogami, Masaru Watanabe, Kazuki Iijima, Yasuyuki Akiyama, Koji Katayama, Toru Futami, Nobuyuki Yamamoto, Takeshi Sawada, Fumiaki Koizumi, Yasuhiro Koh
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130418 (2015)
Development of a reliable platform and workflow to detect and capture a small number of mutation-bearing circulating tumor cells (CTCs) from a blood sample is necessary for the development of noninvasive cancer diagnosis. In this preclinical study, w
Externí odkaz:
https://doaj.org/article/937470a182df4faea931d498140379b5
Autor:
Katsutoshi Ando, Fumiyuki Takahashi, Motoyasu Kato, Norihiro Kaneko, Tokuhide Doi, Yuichiro Ohe, Fumiaki Koizumi, Kazuto Nishio, Kazuhisa Takahashi
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102436 (2014)
We previously reported the role of IL-6 in a murine model of cancer cachexia and currently documented a patient in whom tocilizumab, anti-IL-6 receptor antibody, dramatically improved cachexia induced by IL-6 over-expressing lung cancer. Despite this
Externí odkaz:
https://doaj.org/article/db949f60d0db480394777837e9bdccee
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104538 (2014)
Temozolomide (TMZ), a DNA methylating agent, is widely used in the adjuvant treatment of malignant gliomas. O6-methylguanine-DNA methyltranferase (MGMT), a DNA repair enzyme, is frequently discussed as the main factor that limits the efficacy of TMZ.
Externí odkaz:
https://doaj.org/article/20510895677f463a8bb65d2aaae7dec3
Autor:
Akiko Murakami, Fumiyuki Takahashi, Fariz Nurwidya, Isao Kobayashi, Kunihiko Minakata, Muneaki Hashimoto, Takeshi Nara, Motoyasu Kato, Ken Tajima, Naoko Shimada, Shin-ichiro Iwakami, Mariko Moriyama, Hiroyuki Moriyama, Fumiaki Koizumi, Kazuhisa Takahashi
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86459 (2014)
Accumulating evidence indicates that a small population of cancer stem cells (CSCs) is involved in intrinsic resistance to cancer treatment. The hypoxic microenvironment is an important stem cell niche that promotes the persistence of CSCs in tumors.
Externí odkaz:
https://doaj.org/article/6fe64e8a410a4a28a601b63bfd11afbb
Autor:
Fumiaki Koizumi, Tomohide Tamura, Kazuhisa Takahashi, Fumiyuki Takahashi, Yoshiharu Maeda, Tatsu Shimoyama, Yuka Kitamura, Takeshi Sawada, Yusuke Nakadate, Ryo Ko, Satoru Kitazono, Yu Fujita, Shigehiro Yagishita
(A) WB analysis of HER2 expression after exposure of the indicated SCLC cells to CDDP at IC10 and IC50 concentrations for the indicated times. (B) WB analysis of HER2 expression after exposure of SBC-3 and SBC-5 cells to ETP and CPT-11 at their IC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43c7d67ec3bbefd59ea15501d6dffa5
https://doi.org/10.1158/1535-7163.22501128.v1
https://doi.org/10.1158/1535-7163.22501128.v1
Autor:
Fumiaki Koizumi, Tomohide Tamura, Kazuhisa Takahashi, Fumiyuki Takahashi, Yoshiharu Maeda, Tatsu Shimoyama, Yuka Kitamura, Takeshi Sawada, Yusuke Nakadate, Ryo Ko, Satoru Kitazono, Yu Fujita, Shigehiro Yagishita
WB analysis for downstream intracellular signaling of HER2 after exposure to CDDP (IC50 concentration), trastuzumab (1 μg/ml), and CDDP plus trastuzumab.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa81377fb6c3a5f9634fc726bc772b49
https://doi.org/10.1158/1535-7163.22501125
https://doi.org/10.1158/1535-7163.22501125
Autor:
Fumiaki Koizumi, Tomohide Tamura, Kazuhisa Takahashi, Fumiyuki Takahashi, Yoshiharu Maeda, Tatsu Shimoyama, Yuka Kitamura, Takeshi Sawada, Yusuke Nakadate, Ryo Ko, Satoru Kitazono, Yu Fujita, Shigehiro Yagishita
The primer sequences for qRT-PCR analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcca26e24eef21908fcd3356dfe15f7a
https://doi.org/10.1158/1535-7163.22501119
https://doi.org/10.1158/1535-7163.22501119
Autor:
Fumiaki Koizumi, Tomohide Tamura, Kazuhisa Takahashi, Fumiyuki Takahashi, Yoshiharu Maeda, Tatsu Shimoyama, Yuka Kitamura, Takeshi Sawada, Yusuke Nakadate, Ryo Ko, Satoru Kitazono, Yu Fujita, Shigehiro Yagishita
Small cell lung cancer (SCLC) accounts for 15% of all lung cancer cases and is a highly lethal disease. For the last several decades, the standard treatment for SCLC has been deadlocked, and new therapeutic strategies are urgently needed. HER2 is a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9919805bfae4eb8464d1435922b798f
https://doi.org/10.1158/1535-7163.c.6536682.v1
https://doi.org/10.1158/1535-7163.c.6536682.v1