Zobrazeno 1 - 10
of 325
pro vyhledávání: '"Fumiaki ITO"'
Autor:
Hanjing Yang, Josue Pacheco, Kyumin Kim, Ayub Bokani, Fumiaki Ito, Diako Ebrahimi, Xiaojiang S. Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract APOBEC3G, part of the AID/APOBEC cytidine deaminase family, is crucial for antiviral immunity. It has two zinc-coordinated cytidine-deaminase domains. The non-catalytic N-terminal domain strongly binds to nucleic acids, whereas the C-termina
Externí odkaz:
https://doaj.org/article/bb63ad332d774f9597264326bccad232
Autor:
Mitsuo Koizumi, Fumiaki Ito, Jaehong Lee, Kota Hironaka, Tohn Takahashi, Satoshi Suzuki, Yasunobu Arikawa, Yuki Abe, Zechen Lan, Tianyun Wei, Takato Mori, Takehito Hayakawa, Akifumi Yogo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Laser-driven neutron sources (LDNSs) can generate strong short-pulse neutron beams, which are valuable for scientific studies and engineering applications. Neutron resonance transmission analysis (NRTA) is a nondestructive technique used for
Externí odkaz:
https://doaj.org/article/d6fa113934764ed989f8a4579cf60c83
Autor:
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Robert Betsch, John J. Krais, Bernadette Taberi, Umeshkumar Vekariya, Marissa Calbert, Tomasz Skorski, Neil Johnson, Xiaojiang S. Chen, Richard T. Pomerantz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract DNA polymerase theta (Polθ) is a DNA helicase-polymerase protein that facilitates DNA repair and is synthetic lethal with homology-directed repair (HDR) factors. Thus, Polθ is a promising precision oncology drug-target in HDR-deficient can
Externí odkaz:
https://doaj.org/article/46164b5688fb4f7488433df9b86a86b9
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Human APOBEC3 (A3) cytidine deaminases are antiviral factors that are particularly potent against retroviruses. As a countermeasure, HIV-1 uses a viral infectivity factor (Vif) to target specific human A3s for proteasomal degradation. Vif re
Externí odkaz:
https://doaj.org/article/ccefc56b49dd489c8567077a2c3cd2f0
Autor:
Yuki Kikuchi, Yuji Yada, Yuji Otsuka, Fumiaki Ito, Hiroaki Tanifuji, Hiroshi Komatsu, Hiroaki Tomita
Publikováno v:
Schizophrenia, Vol 9, Iss 1, Pp 1-3 (2023)
Abstract Clozapine-induced fever marks the beginning of its inflammatory and potentially life-threatening adverse effects, such as myocarditis. We retrospectively analyzed the correlation between clozapine titration rate and fever onset date in 254 J
Externí odkaz:
https://doaj.org/article/b5f881104ece48a08501971713e912db
Autor:
Yusuke Hatakawa, Rina Nakamura, Toshifumi Akizawa, Motomi Konishi, Akira Matsuda, Tomoyuki Oe, Motoaki Saito, Fumiaki Ito
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 586 (2024)
Despite the extensive research conducted on Alzheimer’s disease (AD) over the years, no effective drug for AD treatment has been found. Therefore, the development of new drugs for the treatment of AD is of the utmost importance. We recently reporte
Externí odkaz:
https://doaj.org/article/3dc6c8224bc8487d9553531a7e0cd4bb
Autor:
Hanjing Yang, Fumiaki Ito, Aaron D. Wolfe, Shuxing Li, Nazanin Mohammadzadeh, Robin P. Love, Maocai Yan, Brett Zirkle, Amit Gaba, Linda Chelico, Xiaojiang S. Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
APOBEC3G (A3G) belongs to the DNA/RNA cytosine deaminase family that plays important roles in innate immunity against HIV and internal retroelements. Here the authors report the structures of two full-length A3G variants that provides insight into do
Externí odkaz:
https://doaj.org/article/81810bdeadd84813b61a8392fef16fb6
Autor:
Fumiaki Ito, Tomoyuki Ito
Publikováno v:
Antioxidants, Vol 9, Iss 5, p 362 (2020)
Lipid markers are well-established predictors of vascular disease. The most frequently measured lipid markers are total cholesterol, high-density lipoprotein (HDL)-cholesterol (HDL-C), LDL cholesterol (LDL-C), and triglyceride. HDL reduces atheroscle
Externí odkaz:
https://doaj.org/article/d5af88d6a3564ab5a96569bdede878c2
Autor:
Kenji Ohe, Shinsuke Miyajima, Tomoko Tanaka, Yuriko Hamaguchi, Yoshihiro Harada, Yuta Horita, Yuki Beppu, Fumiaki Ito, Takafumi Yamasaki, Hiroki Terai, Masayoshi Mori, Yusuke Murata, Makito Tanabe, Ichiro Abe, Kenji Ashida, Kunihisa Kobayashi, Munechika Enjoji, Takashi Nomiyama, Toshihiko Yanase, Nobuhiro Harada, Toshiaki Utsumi, Akila Mayeda
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
Objectives: The high-mobility group A protein 1a (HMGA1a) protein is known as a transcription factor that binds to DNA, but recent studies have shown it exerts novel functions through RNA-binding. We were prompted to decipher the mechanism of HMGA1a-
Externí odkaz:
https://doaj.org/article/76c23936aee64c6f9f8954b21cd6cb5d
Publikováno v:
Antioxidants, Vol 8, Iss 3, p 72 (2019)
Endothelial dysfunction is one of the initial steps in the pathogenesis of atherosclerosis and development of cardiovascular disease in patients with diabetes mellitus. Several risk factors are associated with endothelial dysfunction and atherosclero
Externí odkaz:
https://doaj.org/article/f0a6022314de4d45887ba1644ddf65ec